Translating GWAS loci is still a complex process, most hits have large amounts of LD and we need to test putative causal variants in tissue/cell-specific contexts. Farrow et al. take the MPRA approach to assigning function to Parkinson loci. Nice work @SophieFarrow2
Replying to @SophieFarrow2
In agreement with previous studies, the variants that we identified to be acting as regulators (i.e., enhancers) were not typically the tag GWAS variant, indicating the need for deeper exploration of these loci.
Dr. Megan Leask retweeted
The work provides the required scientific foundation for the rapid development of safe and effective ways to treat and prevent Hyperemesis Gravidarum @IMS_MRL
This will change how we work with zebrafish!
pIGLET: Safe harbor landing sites for reproducible and efficient transgenesis in zebrafish biorxiv.org/cgi/content/shor… #bioRxiv
Sounds like a super cool project!!!
We have a PhD project available as part of our new @MarsdenFund grant, using zebrafish as a model to explore genetic variants in brain development. Please share! @GeneticsOtago @otago @JuliaHorsfield @OtagoBiochemist @ray_sankalita @NclSteph
findaphd.com/phds/project/ex…










