Learning about aging and longevity / Étudier le vieillissement et la longévité

Université de Moncton
Joined January 2016
Our lab is looking for motivated Ph.D. students and postdoctoral researchers to study how nucleo-cytoplasmic protein partitioning affect proteostasis, autophagy and aging using C. elegans. DM here. Please check our website: sites.google.com/view/lapier…
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A majority of applicants for the NIH K99/R00 postdoc fellowship are international candidates: this is practically the only way, without CNS and/or being from HHMI-NAS lab, for a non-US postdoc to access top US R1 faculty posts and a stepping stone to obtaining future NIH funding.
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CIHR Project Grant app stats for Spring 2026 competition are available! Substantially more streamlining across the board - about 1000 more applications than the 2019-24 competitions. @CIHR_IRSC 🤔 cihr-irsc.gc.ca/e/54787.html…
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Here is the latest from our lab published in @Aging_Cell A perspective on the emergence of spatial proteostasis as an important contributor of aging, with a primary focus on dysfunction in karyopherins, key mediators of nucleocytoplasmic protein transport. onlinelibrary.wiley.com/doi/…
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Would love to hear from other Canadian researchers about how the Impact+ Chair apps are going. Seems quite rushed and eligibility for exceptional worldwide researchers doesn't factor in that they might not want to move at this point in their career unless 2-3X more $. @CIHR_IRSC
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Arguably, it could have been a better long-term investment to target (1-yr search) recently-tenured rock star mid-stage associate prof. looking to move to a stable country (or back home) while expanding their capacity in a research-intensive university. canada.ca/en/impact-plus-cha…
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Here’s our latest review on karyopherins in proteostasis and aging. We present the latest on the role of karyopherins in modulating spatial proteome dynamics with an emphasis on diseases of aging. A great effort from our project leaders in our lab. 🧬🇨🇦 sciencedirect.com/science/ar…
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This is a major issue in faculty hiring: Letters of recommendation at the application stage are not needed. Time wasted: 400+ applicants x 3 letters - only about 1% get interviewed. Simple and less-biased solution: only ask letters of recommendations when finalizing short list.
I recall being very surprised to find out that a recommendation letter and advisor’s name are VERY important in faculty hiring. I had assumed it should be research interests (their diversity and depth), prior experience/papers and research vision (which is most important!). But no, recommendations turned out to shape who’s invited to campus interviews. Ever since, I’ve been questioning this approach. Is it appropriate to give recommendations so much weight, given all the inequity and bias this approach has? Many people will say: “Yes, it helps us decide on a candidate quickly”. However, now looking from the PI’s side, I am still inclined to think that no, it’s not worth it. ♦️ Major PROS: 1. Decisions can be made fast when you have too many applications. 2. Using the letter, you can learn about their personality, passions, trustworthiness, etc. This is by far the biggest reason why so many committees use references. They also can call the advisor directly. ♦️ Major CONS: 1. Recommendations can have a lot of fluff. ‘Amazingly unique’ candidates turn out to be below average during interviews. 2. The advisor’s NAME on that letter has a huge effect. This limits career opportunities for those excellent candidates who were not lucky enough to have “that big name writing a 2-page reference” for them. 3. Strong students may receive bad recommendations because their advisor was unhappy about something small (or simply toxic). There are many stories of students whose careers were destroyed by supervisors via bad recommendations. 4. Many advisors don’t know how to write strong letters. When poorly written, a recommendation letter devaluates a strong candidate. ♦️ Ethical issues with recommendations: 1. Recommendations promote elitism. “You are not from a famous advisor’s group..? Sorry, you don’t belong here.” 2. Recommendation can be used to indirectly control students and postdocs: “You don’t want to spend 15 hours a day on your research? But then how can I write a good recommendation letter for you?” 3. Recommendations can be used to cut opportunities for students (it's rare though): “This student is so good… I don’t want him to go to my competitor’s group and transfer my lab’s expertise there. A dull reference will save me.” 4. Students don’t report their advisors’ inappropriate behavior because they need good recommendation letters from them. 📍 My current view is: Recommendations are useful when they are accurate. But advisor’s bias, lack of experience, lack of interest and sometimes even retaliation - it all negatively impacts the outcome. I think it all comes down to: “Do I want to hire fast, or do I want to hire fairly?” ___
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At US R1s faculty searches, scientific network is probably worth over 50% of the evaluation. Having a former postdoc advisor chairing relevant NIH panels is prized, especially when paylines are single digit. Faculties are all looking to get an edge by hiring connected prospects.
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This is also a de-risking financial strategy of the hiring institution that favors postdoctoral applicants from well-connected labs in prestigious institutions. Obtaining an R01 (+ overhead $) is extremely difficult in this ultra-competitive era. Connections can improve the odd.
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Louis R. Lapierre Laboratory retweeted
Validation of tissue-specific RNAi systems in C. elegans reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin ... biorxiv.org/content/10.64898… #biorxiv_genetic
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Preprint in time for #KSUbiquitin26! We validated commonly used strains for tissue-specific RNAi systems in C. elegans. We uncovered the germline as a key tissue for proteasomal function and vitellogenin turnover, and UBQ-1/UBC as a vitellogenin modulator. biorxiv.org/content/10.64898…
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We found that germline proteasomes are highly active. Gonadally accumulated vitellogenins are major contributors to total polyUb proteins. Striking difference in proteasomal burden between germline and soma reshapes how we think about tissue-specific proteostatic dynamics.
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Finally, we found that polyubiquitin (UBQ-1/UBC) isn’t just a player in proteostasis, but is also essential for maintaining transcription of highly expressed genes, including vitellogenins. Our work uncovered a regulatory link between UBQ-1, vitellogenin metabolism, and lifespan.
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Our laboratory is extremely grateful to NB Research @NBHRF for supporting our translational research on neurodegenerative diseases via the Research Professional Fund mechanism. Thank you! Toute notre équipe est vraiment reconnaissante de votre support. Merci beaucoup!
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Thank you to the team @sbpdiscovery for inviting me to a panel discussion on careers in science with current postdoctoral fellows and the challenges and opportunities with transitioning back to Canada to lead a lab! Reminiscing on how awesome and a great science hub San Diego is!
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Glad to see that our provincial government is feeling the same way about this. Talented students are everywhere, and proper nutrition is one way to make sure they all thrive - the impact on the future of society is enormous. @susanholt @Gov_NB
BREAKING: NFL Legend Jerry Rice and Wife erase $667,000 in School Lunch Debt Across 103 Schools — "A Victory Greater Than the Super Bowl" ❤️ Jerry Rice and his wife have wiped out over $667,000 in unpaid school lunch debt, benefiting thousands of children across the country. 👍🏾👍🏾
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This is the future of scientific publications.
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedScience & @openrxiv @biorxivpreprint! Let's go back to concentrating on making discoveries, and not on “getting published”, because it’s not going to matter soon, when feedback & evaluation are detached from the journals. Preprint + q.e.d = your science is out there, and anyone can appreciate it 👇
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New quote for peer reviewers: "I am one with AI and AI is with me" @qedScience
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