Asst. Prof. & Head Gobind Khorana Protein Engineering Core @ UBC | Studying transcriptional condensates in cancer. Leaving X. Follow me on LinkedIn.
Vancouver, British Columbia
Joined November 2015
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Thank you to @AndreaMiyahira and @PCFnews and for the opportunity to discuss our research on AR-V7 transcriptional condensates in advanced prostate cancer models. This work was led by @ShabnamMassah, a talented post-doctoral trainee in my lab.
Understanding AR-V7 transcriptional condensates in advanced #ProstateCancer models. @Lallousnada @UBC joins @AndreaMiyahira @PCFnews revealing AR-V7 forms condensates without androgens—unlike full-length AR. These structures target chimeric FOXA1-AR sites & drive hypoxia/KRAS programs.
Disrupting condensates uncovers distinct gene signatures tied to progression.
Future: proteomics + genomic determinants = new therapy paths.
#WatchNow > bit.ly/4jZvHFN
Check out our bioRxiv preprint summarizing our work on AR-V7 condensates, their role in activating a specific gene signature, and enhancing its expression in CRPC models. This work, led by post-doctoral trainee @ShabnamMassah, benefited greatly from co-authors and collaborators.
Excited to share our preprint from @Lallousnada lab on AR-V7 transcriptional condensates on bioRxiv! We explored AR-V7-mediated condensate-dependent and -independent transcription in CRPC models, examining their expression dynamics and binding site density biorxiv.org/content/10.1101/…
Excited to share our study led by @janefoofoo published in Breast Cancer Research! The paper explores novel inhibitors targeting the estrogen receptor activation function 2 (ER-AF2), a promising strategy for overcoming resistance in breast cancer
pubmed.ncbi.nlm.nih.gov/3959…
Nada Lallous retweeted
Best of 2024: The 9th Annual @PCF_Science Gender Equity Networking Initiative (GENI) Forum🥰
Nada Lallous retweeted
How does AR activation affect gene expression? Our new paper shows it’s less about creating new loops and more about amplifying contact frequency in existing ones. Explore in @NatureComms (rdcu.be/dYYOL) Tweetorial below: #AR #Epigenetics #prostatecancer
So excited to be part of the Girls and STEAM summit @scienceworldca today! We are ready to meet our potential future scientists soon!
#STEAMForAll #FutureInnovators #DiversityInSTEAM #GirlsInSteam #StrongSmartBold #ScienceWorldVancouver #ScienceWorldca
Nada Lallous retweeted
Thank you to all who attended #PCFRetreat23! It was truly our best conference ever with old & new friends and exciting cutting edge #ProstateCancer and other research presented. We hope everyone had a safe trip home & thank you for attending!
@PCFnews @urotoday
Nada Lallous retweeted
A great turnout of researchers and runners at the #TerryFoxRun in Stanley Park, Vancouver.
Off to the #TerryFoxRun to support cancer research! Mom and daughter bonding time for a great cause!
#CancerResearch #AcademiaMom
@tfri_research @TerryFoxCanada @VanProstateCtr @UBCmedicine
Nada Lallous retweeted
Checkout the latest work from the lab online today in @MolecularCell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by @Nancybrillet @Prashan10011102 and @TvReshma .
Nada Lallous retweeted
I’m very excited to be in Heidelberg to attend EMBL transcription and chromatin conference. Checkout my poster#179 tomorrow where I will discuss our work @Lallousnada on androgen receptor transcriptional condensate in prostate cancer @Lallousnada,#EMBLTranscripts @HlthResearchBC
Great work showcasing an additional layer of complexity in the role of DNA-bound condensates in living cells!
Chromatin scientists, want to reorganize genomic loci as you wish?
Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/S0092…
What a beautiful wrap-up of the @ProteinSociety meeting with two stunning talks by @fordycelab and @NLKProteomics. This meeting was one of the best meetings I have ever attended! I met wonderful and supportive scientists, and I am so glad that I joined this community!
Nada Lallous retweeted
. @ProteinSociety annual symposium in Vancouver! What an absolute treat this meeting has been!! 🥳 thanks to the organisers for the invitation and for putting on such a fantastic meeting!
@Lallousnada @SpruijtLab 💃🏽
