@Labtacular

U of Iowa BMB Professor with a passion for modeling rare human diseases in Drosophila, #musculardystrophy #lamins #retinitispigmentosa #RNAsplicing #chromatin

 University of Iowa
biochem.uiowa.edu/wallrath/index.html
Joined October 2012
  • Tweets934
  • Following1.3K
  • Followers722
76Media
Lori L Wallrath retweeted
Muscle Cell News
@musclecellnewsJan 19
🔬 This study identifies FGF12 as a critical regulator of aberrant mechanosignaling in aortic smooth muscle cells and a key contributor to thoracic aortic aneurysm formation in Marfan syndrome. 🔗 go.nature.com/49wUyPa
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Lori L Wallrath retweeted
Cell Press@CellPressNews29 Nov 2025
Vascularized hiPSC-derived 3D cardiac microtissue on chip hubs.li/Q03SM0QW0 Article highlight from @stemcellreports (@ISSCR) @LUMC_Leiden
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This study delineated the state-of-the-art of muscle models by performing a large-scale analysis of transcriptome datasets, covering over 400 samples across 39 studies, including bulk and single-cell RNA sequencing of 2D and 3D models. @stemcellreports | bit.ly/47w9Npo
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Lori L Wallrath retweeted
Nature Plants@NaturePlants28 Oct 2025
New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" rdcu.be/eM95H m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
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Congratulations to Dr. Steve Henikoff on receiving the 55th Rosenstiel Award for his research on genome organization and gene expression! The award is given for recent discoveries of particular originality and importance to basic medical research. brandeis.edu/stories/2025/oc…

Professor Steven Henikoff receives 55th Rosenstiel Award for research on genome organization and...

brandeis.edu
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Lori L Wallrath retweeted
FlyBase@FlyBaseDotOrg16 Sep 2025
The FlyBase situation has made the national news nbcnews.com/science/science-…

Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly

This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.

nbcnews.com
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New #SciTransMed paper: ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy. tinyurl.com/5ab8csxd
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Happy to share our recent work showing bulk transport of speckle material between nuclear speckles within dynamic, multi-phase, linear connections. Nonrandom interchromatin trafficking through dynamic multiphase speckle connections biorxiv.org/content/10.1101/…

Nonrandom interchromatin trafficking through dynamic multiphase speckle connections

Nuclear speckles (NS) enhance the expression of NS-associated genes, possibly by elevating local levels of factors involved in multiple steps of gene expression. While dozens of large NS are distri...

biorxiv.org
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Lori L Wallrath retweeted
Eric Topol
@EricTopol18 May 2025
This week's genome editing triumph is a big deal. Here's why erictopol.substack.com/p/the…
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Our recent studies on genetic modifiers of LMNA-associated muscular dystrophy identify components of SMAD signaling as potential therapeutic targets. science.org/doi/10.1126/scia…

A genetic variant in SMAD7 acts as a modifier of LMNA-associated muscular dystrophy, implicating...

Genetic variation in SMAD7 is associated with severe LMNA-MD by enhancement of SMAD signaling, offering therapeutic options.

science.org
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Lori L Wallrath retweeted
Gonzalo’s Lab@gonzalo_lab7 Apr 2025
Excited to share our pre-print about a non-canonical cGAS-STING pathway in aging. biorxiv.org/content/10.1101/…
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For the first time, researchers have used the #CRISPR gene editor to repair a flawed gene in the human body. scim.ag/4kF7dTI @NewsfromScience

Gene editing fixes DNA—and treats incurable lung and liver disease

A promising clinical trial marks another milestone for the CRISPR gene editor

science.org
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Blown away by the incredible research on muscle disease pathology and treatments at the Muscular Dystrophy Association’s 75th Anniversary Clinical and Scientific Conference! @MDAorg
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Lori L Wallrath retweeted
Lammerding Lab@LammerdingLab11 Mar 2025
Interested in nuclear #mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @J_Cell_Sci: journals.biologists.com/jcs/…
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💪 To find factors associated with muscle integrity, researchers at @Inserm perform an siRNA screen and identify SH3KBP1 as a new factor controlling #myoblast fusion, myonuclear positioning, and myotube elongation. @emboreports | bit.ly/4bKOzph
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SAVE THE DATE!! The Dystroglycanopathy Patient & Family Conference will be held June 20th & 21st at the Graduate Hotel in Downtown Iowa City!
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We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research. R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics. Read an In Memoriam published in Genes to Genomes: buff.ly/3EoNQh8
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Proud of Nathan Mohar, a graduate student in my lab, who was selected for the U of Iowa “Dare to Discover” campaign. Nathan is linking DNA sequence variation to phenotypic characteristics of LMNA-muscular dystrophy.
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Congratulations to our own Dr. Mathews on the MDA Legacy Award for Achievement in Clinical Research!
Muscular Dystrophy Association@MDAorg21 Jan 2025
We’re thrilled to honor Dr. Katherine Mathews from @IowaMed and Donavon Decker at the 2025 #MDAConference! 🎉 🏅 Dr. Mathews: MDA Legacy Award for Achievement in Clinical Research 🏅 Donavon Decker: MDA Legacy Award for Community Impact in Research More: mda.org/press-releases/2025/…

Muscular Dystrophy Association’s Legacy Awards Honor Pioneers in Clinical Research and Community...

Dr. Katherine Mathews to receive MDA Legacy Award for Achievement in Clinical Research; Donavon Decker to receive MDA Legacy Award for Community Impact in Research.

mda.org
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Lori L Wallrath retweeted
Molecular Cell@MolecularCell13 Jan 2025
Online Now: Structural basis of 5′ splice site recognition by the minor spliceosome dlvr.it/THLDnx
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