Personal views on the state of the world and occasional bits of science, especially axon degeneration and research culture. Much more science at š¦ @colemanlab
Cambridge, England
Joined July 2017
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Not all grant rejections are equal. Some are more devastating than others. As a researcher, how do you keep going in those moments?
The latest Science Without Anguish blog post discusses a topic we need to talk about much, much more!
sciencewithoutanguish.com/blā¦
Michael Coleman retweeted
Programmed axon death, SARM1, and the potential to treat conditions like ALS and peripheral neuropathy.
This, and more, in our latest interview with expert researcher @Lab_Coleman š„¼š¬š§« #PNS2026
Michael Coleman retweeted
Back from #ESHG2026. Presented work on #RNAseq resolving unsolved cases, reconnected with old collaborators, and excited about new research ahead. Exactly why this community matters. #RareDisease #Genomics
@IonSynapse
Michael Coleman retweeted
Research Associate role at the University of Cambridge studying blood pressure, vascular health and dementia using imaging, genetics and population data. Closing date: 12th July
dementiaresearcher.nihr.ac.uā¦
Michael Coleman retweeted
āI apologize, but this is a very busy period and therefore I canāt review this paper. However, I can recommend someone who can do a good job.ā
Michael Coleman retweeted
How does the thalamus support consciousness?
Our new study uses restingāstate fMRI to show nucleusāspecific thalamocortical connectivity changes during anaesthesia and in disorders of consciousness.
#Neuroscience #Consciousness #fMRI #Thalamus
academic.oup.com/braincomms/ā¦
Delighted to announce the latest preprint from our amazing team: biorxiv.org/content/10.64898ā¦
Laura Carlton and Emma Wilson report luciferase mapping of the human NMNAT2 and SARM1 promoters, naturally-occurring human gene variants within them and their functional consequences.
1/5
Importance: These findings support disease association studies to link programmed axon death to specific human diseases. It is essential to move beyond the limitations of animal models and work in humans to understand where best to apply drugs blocking programmed axon death. 4/5
Michael Coleman retweeted
Grateful & excited:
New paper alert by Simone Thomas with contributions from other @merkinpnnrcenter.bsky.social scholars ālive on PubMed now.
pubmed.ncbi.nlm.nih.gov/4150ā¦
#MerkinCenter #MerkinScholars #PeripheralNeuropathy #NerveRegeneration #TeamScience #Neurology #JohnsHopkins
Michael Coleman retweeted
Delighted to say that our paper identifying a novel role for protrudin in endosomal fission has been published:
Protrudin acts at ER-endosome contacts to promote KIF5-mediated endoso... sciencedirect.com/science/arā¦
@TheCIMR @juliakleniuk
Today in Science Without Anguish:
'It's not what you know, it's who you....trust'.
When knowledge is really trust in disguise. And it's not absolute, itās greyscale.
Why knowing this helps us cope when our knowledge is challenged. sciencewithoutanguish.com/blā¦
This is dreadful. Do we have to cave
into Trumpism? This is not the US! Itās very simple: research in a culture of fear just doesnāt work. sciencewithoutanguish.com/blā¦. Funding research without also addressing culture is a waste of money.
šØBREAKINGšØ
REF 2029: Research culture metric overhauled (and weighting reduced).
Research Excellence Framework reworked āto reduce burdenā, with elements of 2021 exercise reinstated.
All the headlines as the three-month pause ends. Free to read.
researchprofessionalnews.comā¦
Question to non US scientists: What effect will the proposed social media checks by US border control have on your willingness to attend conferences in the US?
0%More likely to attend
50%No significant change
25%Less likely to attend
25%Very unlikely to attend
4 votes ā¢ Final resultsToday in Science Without Anguish: how we handle experiences that donāt fit our mental map. The many ways that cognitive dissonance plays out in academic research and the problems this causes us. sciencewithoutanguish.com/blā¦
Science WITH Anguish?
Grant rejection today. It never stops hurting no matter how successful or how many you dealt with before (this is no. 57). Thanks to my team for helping me handle it today. š Tomorrow we go on.
ECRs dealing with rejection: know that you are not alone!
Today in Science Without Anguish: Is blame bringing you down?
How we shackle ourselves by blaming others, also degrading workplace culture and raising our stress levels.
But can we avoid it without blaming ourselves instead?āØ
sciencewithoutanguish.com/blā¦
