@LabYoule

Youle Lab members. Mitophagy, mitochondrial quality control and autophagy lab. Molecular mechanisms underlying early onset Parkinson's disease.

 Bethesda,MD
Joined June 2020
  • Tweets50
  • Following119
  • Followers1.1K
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YouleLab retweeted
YouleLab@LabYoule23 Aug 2022
Replying to @slavov_n
Pink1 is another example of a protein constitutively translated only to be degraded. Upon import impairment of an individual mitochondrion Pink1 proteolysis is prevented allowing it to accumulate on that mitochondrion to recruit Parkin and initiate mitophagy.
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Found a spooky #bacteria #ghost transformation in the Lab!!! @LabYoule #GlowintheDark #halloween2021 #GFP #ScienceIsFun 👻🎃💀
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The VPS13 proteins are thought to mediate #lipid transport between organelles & are linked to distinct neurological disorders. Baldwin, @LabYoule et al. find that, in addition to mitochondrial morphology, VPS13D is essential for peroxisome biogenesis. bit.ly/3sMSxpq
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YouleLab retweeted
mito911@mito911_20 Apr 2021
📌Talk by Richard Youle @youle_rj @LabYoule 🗓️12th May 2021 - 1pm EDT REGISTER HERE: zoom.us/webinar/register/WN_…
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Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. A novel pooled screening approach from Gil Kanfer (@gil_kanfer) Richard Youle (@youle_rj) and colleagues from @LabYoule @JLS_Lab: bit.ly/3bURzCz #autophagy #mitochondria #AI
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Looking to leverage existing systems to clear out protein aggregates to tackle neurodegenerative diseases such as #ALS #MND? @MolecularCell Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain bit.ly/32TWbUq @LabYoule
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YouleLab retweeted
The Nobel Prize
@NobelPrize7 Oct 2020
BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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#VKSautophagy21 2nd day starts with Richard Youle @LabYoule , talking on novel forms of selective #autophagy
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YouleLab retweeted
The Nobel Prize
@NobelPrize5 Oct 2020
BREAKING NEWS: The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”
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New Breakthrough Prize in Life Sciences laureate Richard Youle @NIH @NINDSnews has discovered the cellular pathway that clears away damaged mitochondria - the power generators of the cell - and which, when it goes wrong, is a cause of Parkinson’s disease. breakthroughprize.org/News/6…
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New commentary from @LabYoule discusses new research on two different axes (CALCOCO2-RB1CC1 & OPTN-ATG9A), and how they initiate #Parkinsons-associated PARKIN-mediated mitophagy tandfonline.com/doi/full/10.…
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Today we report in @nature, in collaboration with the labs of Joseph Mougous and @VamsiMootha, the development of a new class of CRISPR-free base editors that enable precision editing of mitochondrial DNA (mtDNA) for the first time. drive.google.com/file/d/1xHc… 1/7
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Interesting approach for imaging-based pooled CRISPR screens by Ron Vale's lab and @JswLab. 1/Identify cells with phenotype of interest by high-content imaging. 2/ Tag cells by switching on a photo-activatable FP. 3/ Sort cells by FACS.
bioRxiv@biorxivpreprint1 Jul 2020
High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells biorxiv.org/cgi/content/shor… #bioRxiv
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Negative stain #ElectronMicroscopy helps show that the N-terminal domain of FIP200 acts as a homodimer to scaffold the #autophagy-initiating ULK1 complex. Taken from the new study by @XiaoshanShi1 @AdamYokom @lindsey__young @TheHurleyLab and colleagues: bit.ly/2UpSxxp
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We are super excited to present our newest #publication in the @embojournal : "MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation" embopress.org/doi/10.15252/e… #mitochondria #superresolution #EM
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YouleLab retweeted
The Nobel Prize
@NobelPrize22 Jun 2020
"I am, and always have been, passionately curious," says Chemistry Laureate Ada Yonath. How do we encourage the next generation to study science? "By respecting their curiosity," she says. Wishing a happy birthday to Yonath, 81 today. Learn more: bit.ly/2D5EwMo
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Very sad day for the @Autophagy field. Beth Levine has died after a long fight against cancer. She will always be a reference for the field, as a woman and as a scientist.
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New Resource online now at Cell: Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration zpr.io/tVgyK
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