@LabVacha

Biological membranes, proteins. and their interactions at @CEITEC_Brno

 Brno, Czech Republic
vacha.ceitec.cz/
Joined June 2019
  • Tweets117
  • Following110
  • Followers729
26Media
These two works now have their great covers as well 🙂
VachaLab@LabVacha14 Jan 2025
Replying to @LabVacha
Third, @RivelTimothee and @DenysBiriukov presented new collective variables to study the energetics of lipid membrane pores. pubs.acs.org/doi/10.1021/acs… Good job!

Free Energy of Membrane Pore Formation and Stability from Molecular Dynamics Simulations

Abstract. Understanding the molecular mechanisms of pore formation is crucial for elucidating fundamental biological processes and developing therapeutic s

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Robert Vácha from @CEITEC_Brno @MasarykUni has been awarded ERC Proof of Concept grant for preclinical testing of new antimicrobial peptides that have the potential to significantly contribute to the fight the antibiotic resistance in bacteria. Congratulations! 👏 #CEITECScience
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Prof. Robert Vácha @LabVacha je mezi úspěšnými žadateli, kteří získali grant Proof of Concept @ERC_Research 👏 Podpořený projekt se bude věnovat boji s rezistentními bakteriemi s pomocí antimikrobiálních peptidů. 👇👇👇
European Research Council (ERC)
@ERC_Research23 Jan 2025
An archaeologist will aid the fight against food fraud. A computational biologist will help find new drugs to combat cancer & a biomedical engineer will better visualise blood microcirculation. More on the exciting new #ERCPoC projects 👉 europa.eu/!GBpV8W @EUScienceInnov
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We’re off to a strong start in 2025. First, work of Láďa on enhanced diffusion received a beautiful cover. pubs.rsc.org/en/content/arti…
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Second, Mehrnoosh showed how to "split" lipids to accelerate the sampling of all-atom lipid membranes. pubs.acs.org/doi/10.1021/acs…

Split Membrane: A New Model to Accelerate All-Atom MD Simulation of Phospholipid Bilayers

Abstract. All-atom molecular dynamics simulations are powerful tools for studying cell membranes and their interactions with proteins and other molecules.

pubs.acs.org
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Third, @RivelTimothee and @DenysBiriukov presented new collective variables to study the energetics of lipid membrane pores. pubs.acs.org/doi/10.1021/acs… Good job!

Free Energy of Membrane Pore Formation and Stability from Molecular Dynamics Simulations

Abstract. Understanding the molecular mechanisms of pore formation is crucial for elucidating fundamental biological processes and developing therapeutic s

pubs.acs.org
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Grateful for the opportunity to share insights on our work, achievements, and future goals with the @CEITEC_Brno communications team: ceitec.eu/robert-vacha-multi…

Robert Vácha: Multidisciplinarity brings innovative ideas to our team. It makes us grow professio...

Biophysicist Robert Vácha specializes in a rather unconventional field within the life sciences at CEITEC Masaryk University (MUNI) – he uses computer simulations to study interactions between...

ceitec.eu
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Quick updates: check out another stellar work by Láďa Bartoš: pubs.rsc.org/en/content/arti… 👏 Oh, and we're now on 🦋 too!

Enhanced diffusion through multivalency†

The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can b

pubs.rsc.org
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We've received a new GAČR Weave project in collaboration with German and Austrian groups, where we will focus on how lipid asymmetry affects protein function! Thereby, we also have an open Ph.D. position! @CEITEC_Brno vacha.ceitec.cz/jobs-opening…
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Congratulations to Francesco and our collaborators on our latest publication on phase separation and phosphorylation, now live in @NatureComms! @CEITEC_Brno @NIVBcz @ERC_Research nature.com/articles/s41467-0…

Sequence and structural determinants of RNAPII CTD phase-separation and phosphorylation by CDK7

Nature Communications - The authors explore sequence-encoded molecular grammar underlying the liquid liquid phase-separation of the human RNA polymerase II C-terminal domain and demonstrate that...

nature.com
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PhD done! 🙂 @LabVacha @MasarykUni @CEITEC_Brno
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Our research on tackling drug-resistant bacteria has been featured in Czech media again! Check out the coverage here (only in Czech): radiozurnal.rozhlas.cz/magaz…

Magazín Experiment: Jak bojovat s bakteriemi, na které nezabírají antibiotika? A kde pozorovat...

00:00 témata magazínu00:20 Nobelovy ceny za vědu02:50 peptidy proti rezistentním bakteriím07:00 focení bakteriofágů10:45 AI a vyhodnocování vzorků prostaty14:30 rozhovor s Romanem Zachovalem18:30...

radiozurnal.rozhlas.cz
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New group photo. 🤠
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📢 Attention students of @muni_cz @MasarykUni @CEITEC_Brno! Our Survival Guide course on molecular dynamics simulations is back! Based on your feedback from last year, my postdocs have enhanced the course to make it even more accessible and effective. Spread the word and sign up!
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Excellent work by @MehrHaz on antimicrobial peptide Buforin 2 and its behavior within and across cellular membranes! Supported by @ERC_Research & @NIVBcz and done at @CEITEC_Brno pubs.acs.org/doi/10.1021/acs…

Membrane Adsorption Enhances Translocation of Antimicrobial Peptide Buforin 2

Abstract. Despite ongoing research on antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs), their precise translocation mechanism remains elu

pubs.acs.org
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We are thrilled to have our work featured on the cover of #JMedChem !! @ACS4Authors @ACSBioMed @LabVacha @CEITEC_Brno @delafuenteupenn #MyACSCover
Rahul Deb@rahuldeb_in9 Aug 2024
Paper published in #JMedChem, our computer-designed peptides fight bacterial infections and cancer. De novo antimicrobial and pH-sensitive anticancer peptides from the barrel-stave pore class @LabVacha @CEITEC_Brno @MasarykUni @delafuenteupenn @ACSBioMed doi.org/10.1021/acs.jmedchem…

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities

Abstract. Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their op

pubs.acs.org
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We’re thrilled to have our work featured in the Czech media! novinky.cz/clanek/veda-skoly… ct24.ceskatelevize.cz/clanek…

Vědci z brněnského institutu navrhli peptidy, které dokážou ničit bakterie i rakovinné buňky -...

Významný krok vpřed v potírání bakteriálních infekcí, které jsou odolné vůči antibiotikům, udělali vědci z institutu Ceitec Masarykovy univerzity v Brně. Navrhli s pomocí počítačové simulace speciá...

novinky.cz
VachaLab@LabVacha9 Aug 2024
🚨 Just out: Our computationally-designed peptides are taking down bacterial and cancer cells! Incredible work by Rahul Deb! 👏 pubs.acs.org/doi/10.1021/acs…

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities

Abstract. Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their op

pubs.acs.org
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🚨 Just out: Our computationally-designed peptides are taking down bacterial and cancer cells! Incredible work by Rahul Deb! 👏 pubs.acs.org/doi/10.1021/acs…

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities

Abstract. Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their op

pubs.acs.org
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Scientists at @CEITEC_Brno @MasarykUni design nanoparticles for drug delivery through spontaneous membrane fusion 💊 🔬 @LabVacha Read more here 👉 ceitec.eu/scientists-design-… #CEITECScience
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VachaLab retweeted
CEITEC@CEITEC_Brno6 May 2024
Prof. @mleptin, President of @ERC_Research, is coming to Brno on 13 June to open a conference at @CEITEC_Brno @MasarykUni and join a panel discussion on how we can close the gap in the success rate of Czech ERC grant candidates. muni.cz/go/260796 @brnoregion
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