Synthetic and structural biology- newly minted cryoEM expert- Indiana University School of Medicine “That’s not exactly my 2D projection but close”
Joined March 2019
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Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant biorxiv.org/content/10.64898… Delighted to share this collaborative work led by Dr. Wen Zhu’s lab, revealing the mechanistic basis of an ASNS disease-associated mutation.
I am excited to share our latest work, now available on bioRxiv: biorxiv.org/content/10.1101/…
This achievement was made possible through great collaboration with the Staschke (IUSM) and Zhu (FSU) labs.
My cat passed away yesterday at nearly 18 years old. Many of you knew her as the lab’s quiet mascot—her photo appears on our X account and elsewhere. She had been with me through most of my time at IU, offering steady companionship. She will be greatly missed.
Takagi_Lab retweeted
1/2: Publication Announcement! In a new manuscript published in Nature Communications, Dr. Yuichiro Takagi @LabTakagi and collaborators used Cryo-EM to reveal the catalytic mechanism of Human Asparagine Synthetase (ASNS): nature.com/articles/s41467-0…
Takagi_Lab retweeted
Working on ASNS, authors from @LabTakagi @WenZhu_Lab and colaborators combine cryo-EM 3D variability analysis with MD simulations to study conformation of amino acid side chains.
nature.com/articles/s41467-0…
Thrilled to share that our paper has finally been published after navigating feedback from six reviewers over the past year and a half. Huge thanks to the incredible collaboration with the teams of Richards, Zhu, Vos, and Chaptal. rdcu.be/d2iMK
Takagi_Lab retweeted
Matthijn Vos is evaluating student grids at the @cshlcourses cryo-em course. He is a tough judge - a lot of 0/10 grids! @LanderLab @Jen_Cash_11
Takagi_Lab retweeted
can't wait to join in on the 🔥🔥🔥 #cryoEM program led by @yifan_ucsf and superstars @mcianfro @mimi1inh @fitzpatricklab @davidwtaylor @YuanHe_NWU @Mel_Ohi_Lab @AlexisRohou @BrentNannenga Anchi and more at #ACA2023.. 'American Cryo-EM Association'!! 😂
Packed house for the Advanced Topics in #CryoEM & #CryoET Workshop today #ACA2023!!!
Awesome #CryoEM line-up this morning, with exciting talks from @davidwtaylorjr @therickybaker & @FitzpatrickLab!! ❄️🔬
Stay tuned for the stellar #teamtomo line-up on deck after lunch!! ♥️❄️🔬
Our recent work has been deposited into bioRxiv. A great collaboration with the groups of Zhu, Richards, and Chaptal 😊😊: biorxiv.org/content/10.1101/…
Looking for a postdoc to work on small molecule degraders of oncoproteins (Bellail et al. Science Translational Medicine 2021, 13:e12947, DOI:10.1126/scitranslmed.abh1486), and aging related proteins utilizing cryo-EM If interested, please contact me at ytakagi@iu.edu
Takagi_Lab retweeted
We are delighted to share our work, now available in
@Nature:
nature.com/articles/s41586-0…
Our scoring system can be accessed here: kinase-library.phosphosite.o…
Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features!
#TheKinaseLibrary #KL
I am delighted that my lab was able to contribute to a large kinase substrate study with other excellent groups just published in nature 😊: nature.com/articles/s41586-0…
Takagi_Lab retweeted
Finally able to kick off the @CSHL cryoEM course originally scheduled for March 2020! It’s great to be back
Takagi_Lab retweeted
🔥hot off the press from the @kellogg_liz lab 🔥
We report the first cryo-EM structure of a CAST catalytic component, commonly called the transposase. In the V-K CAST system this component is named TnsB, published this week in PNAS! (1/9)
pnas.org/doi/full/10.1073/pn…
Takagi_Lab retweeted
We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new @ChanZuckerberg Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software
🧵czi.co/ImagingInstitute
Takagi_Lab retweeted
New Pikaard lab paper, showing how alternative dicing patterns are programmed for maximal siRNA-directed DNA methylation, just published in eLife. Kudos to former PhD students Loffer and Singh and postdocs Fukudome, Mishra and Wang doi.org/10.7554/eLife.73260
