@LabSkoultchi

We study the control of gene expression in mammalian development and cellular differentiation, with a particular emphasis on chromatin structure and function.

Joined December 2020
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  • Following60
  • Followers91
New @NatureComms publication by the Jenuwein lab. 🎉The team shows how a complete loss of the H3K9 #methylation disrupts #heterochromatin organization in mice & thereby reveals an essential function of this modification in protecting genome integrity. OA: nature.com/articles/s41467-0…

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Nature Communications - Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through...

nature.com
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The LaFave Lab is hiring! We are looking for team members excited about studying chromatin biology in lung cancer. Check out the new lab website for more details: lafavelab.org! Please retweet!
LaFave lab logo

ALT LaFave lab logo

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Watch as mentor Arthur Skoultchi, Ph.D, and Sean Healton, M.D./Ph.D. share what made their Einstein Ph.D. mentoring relationship special. #mentoring #phdlife #graduateschool #edu

Ph.D. Mentoring: Sean Healton

Watch as mentor Arthur Skoultchi, Ph.D, and Sean Healton, M.D./Ph.D. share what made their Einstein Ph.D. mentoring relationship special.

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Online Now: Extended and dynamic linker histone-DNA Interactions control chromatosome compaction dlvr.it/S2j1DD

Extended and dynamic linker histone-DNA Interactions control chromatosome compaction

Using single-molecule optical tweezers, Rudnizky et al. map the structure and dynamics of histone-DNA interactions in a chromatosome at nearly base-pair resolution. A single chromatosome can populate...

cell.com
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It's about time we started talking about the forgotten H1 linker histone variants. Check out our review in @GenesDev for a discussion of emerging trends for H1 variant-specific functions. @ReinbergDanny @CSHL #chromatin #transcription #nucleosome genesdev.cshlp.org/content/3…
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Montefiore-@EinsteinMed received over $223 million in @NIHGov funding in 2020, the largest annual total in the institution's history: einstein.yu.edu/news/2462/al…
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Liquid or solid? Exciting paper from the Hansen and Hendzel labs! cell.com/cell/fulltext/S0092…

Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells

Chromatin in live cells functions as a solid material and provides a scaffold for spatial organization of nuclear components that can adopt a liquid-like state.

cell.com
Thanks @EinsteinMed for featuring our recent work and collaboration with @LabMelnick ! einstein.yu.edu/news/2474/tw…
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Very excited to be part of @LabMelnick @NevinYusufova paper, Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture - a comprehensive project characterizing histone H1 oncomutations. See the video for an overview! 1/n youtu.be/hoWepg1lmWs
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SkoultchiLab retweeted
Yael David@Yael_David__9 Dec 2020
nature.com/articles/s41586-0… nature.com/articles/s41586-0… @NevinYusufova @LabMelnick @SimoneSidoli @GarciaLabMS @mason_lab @jdlicht @efapostolou29 and Art Skoultchi!
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Check out our new Nature paper showing that local H1 density affects chromatin compaction and compartmentalization, gene silencing, and deposition of H3K27me3 and H3K36me2! rb.gy/nnk2qf DM @LabSkoultchi for collabs or if you are interested in studying H1 in the lab!
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