Signoretti Lab retweeted
⭐ We spoke with Sabina Signoretti, MD, of @harvardmed, on her team’s analysis of the phase 2 HCRN GU16-260 trial examining biomarkers of response to frontline nivolumab in metastatic clear-cell #RCC: buff.ly/bdGKDd3
🔎 The study drew on multiplex immunofluorescence and spatial profiling of the tumor microenvironment, and identified immune cell populations associated with favorable and unfavorable outcomes.
Signoretti Lab retweeted
#KCRS25 Oral Abstract: @simsek_berkay_ @BrighamWomens links CD163+ macrophages in RCC tumors to better outcomes with nivolumab. A potential new target for immunotherapy.
Read all the abstracts: bit.ly/AbstractsKCRS25
Register: bit.ly/RegisterKCRS25
#AcceleratingCures
Signoretti Lab retweeted
Pathologist representation at this year’s #KCRS25, one of my most important and favorite meetings each year. 🔬🩺🩻 #gupathology #workingtogethertofightRCC @PayalKapur5 @Unclassified1 @drmehrarohit @kidneycan @OncoAlert @urotoday
Signoretti Lab retweeted
We are looking for a JUNIOR PATHOLOGIST (at least 1 year of residency training) to join our group and lead one of our translational efforts in kidney cancer. Please contact us if you are interested and willing to spend at least 2 years in the lab.
Signoretti Lab retweeted
Thanks to our friends at Cure Today for letting me share some advice for new patients. 👊👊 @DanaFarber @DrChoueiri @DanaFarber_GU @kidneycan @TheJimmyFund @DanaFarberNews curetoday.com/view/finding-s…
Signoretti Lab retweeted
Celebrating Dr Sabina Signoretti @BrighamWomens work and dedication over the years to @DanaFarber @BrighamWomens @df_hcc Pathology!
cc: @LabSignoretti @kaelin_lab @harvardmed
Signoretti Lab retweeted
Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.
Signoretti Lab retweeted
Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert
Signoretti Lab retweeted
Kicking off the Trials in Progress session with #ARCITECT evaluating Botensilimab+Balstilimab for pts with mRCC
A trial that aims to "raise the tail" and a fantastic presentation by @MikeSerzanMD
#KCRS24 @kidneycan @OncoAlert
Signoretti Lab retweeted
Great work from these presenters!
Wonderful Pathology session on KCRS - State of the Science. “This is an Exciting and a Fantastic time to be a Pathologist!” @kidneycan
There's a new version of this post
Signoretti Lab retweeted
The #INTerpath-004 trial explores the combination of pembro + personalized mRNA #vaccine for the adjuvant treatment of pts with RCC. Inspiring talk by @DrChoueiri at #KCRS24!
@kidneycan @DanaFarber_GU @OncLive
Signoretti Lab retweeted
🟢 Outstanding presentation at #KCRS24 @drmehrarohit
🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research
🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications.
🟠 Emphasis on understanding mechanisms to improve patient care.
@KidneyCancer @DrChoueiri @yekeduz_emre @neerajaiims @montypal @NazliDizman @advocatekidneys @HHammersMD @rovingatuscap @BraunMDPhD @DrRanaMcKay @FabioSchutz78 @AlbigesL @OncoAlert #cancer #oncology #KidneyCancer #KCRS24
Signoretti Lab retweeted
We are super interested in the IVC thrombus @UTSWUrology @utswcancer @UTSWHemeOnc! @PayalKapur5 shows IVC correlates and Angioscore for as a biomarker for angiogenic driven tumor. @KCPUTSW #KCRS24 @kidneycan
Prognostic and Predictive Biomarkers in #kidneycancer Very insightful talk by @PayalKapur5 @UTSWMedCenter 👉Tumor thrombus grading predicts metastasis free survival better than primary RCc grading & more👇#KCRS24 @kidneycan @DrChoueiri @JBrugarolas @HHammersMD
Signoretti Lab retweeted
Thank you Chuck for sharing!
It’s very inspiring!
Advocacy, research, and patient care unite to accelerate the cure! We can’t do it alone – we need each other! @kidneycan @DrChoueiri @advocatekidneys #KCRS24 @OncoAlert @CJSTRAV3 #Advocate @HHammersMD @neerajaiims @yekeduz_emre @montypal @NazliDizman
Signoretti Lab retweeted
Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri @brian_rini @Uromigos @AlbigesL #KCRS24
Side note: was running late to the mtg today and used the virtual option to watch Tom’s talk. Thanks to @kidneycan for making it so easy to access!
Signoretti Lab retweeted
#KCRS24 Session 8: Rapid Abstract Presentations are underway!
Tertiary Lymphoid Structures in Sarcomatoid RCC @NickSalgia
Brain-Specific Tropism in mRCC @rmelias2
Latino Ethnicity & Gut Microbiome in mRCC @ReginaBarCar
#KidneyCancer #AcceleratingCures
Signoretti Lab retweeted
Wrapping #kcrs24!
Started my day with rock the run 5k and finished it with insightful discussions and inspiring moments. So glad to be part of kidney cancer research but also part of a great team along the way of curing this cancer!
