Investigating Alzheimer's and Parkinson's disease genomics to understand mechanisms of brain aging, and to improve risk prediction, diagnosis and treatments.
Houston, TX
Joined January 2019
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New insights on the relationship between Alzheimer’s disease, aging, immunity, and neuronal vulnerability—check out our new preprint! doi.org/10.1101/2022.11.14.5…
Is #Parkinson’s one disease or hundreds of different conditions? What is the difference between sporadic and familial disease? What is a “PD gene” really? Can we distill coherent biology? Check out our new @AnnualReviews on Parkinson’s syndrome! doi.org/10.1146/annurev-path…
Amazing visit to the CABD in beautiful Sevilla! Thanks to Lola and Acaimo for inviting / hosting and to all for the stimulating conversations!
Today Joshua Shulman @LabShulman from @bcmhouston delivered a great talk about brain transcriptomics involved in aging and Alzheimer’s to the #CABD community! 🧠🪰 Followed by an informal get together with PhD students! Dr. Shulman is being hosted by @mdmarber!
In our latest preprint, we pinpoint 15 lysosomal storage disorder gene modifiers of alpha-synuclein #neurodegeneration, including many known or likely #Parkinsons disease risk genes! biorxiv.org/content/10.1101/…
Genome sequencing in the Parkinson’s Disease clinic—are we ready yet? Our new preprint grapples with the promise and pitfalls of personalized genomic medicine for PD: doi.org/10.1101/2021.11.23.2…
Work with outstanding colleagues at the Duncan Neurological Research Institute (nri.texaschildrens.org). New Baylor College of Medicine tenure-track/tenured faculty search for neurodegenerative disease research: dropbox.com/s/ewt0h4phsmx4tb…
Our new Baylor Center for Alzheimer’s and Neurodegenerative Diseases is searching for 3 tenure-track faculty, including basic and clinician-scientists! Join our team: dropbox.com/s/ed5y6ozv7wnqvi…
Resolving Parkinson’s disease heterogeneity for precision therapies! New publications highlight the promise of genetics and enhanced motor phenotyping:
prd-journal.com/article/S135…
ng.neurology.org/content/7/2…
An integrated transcriptome-proteome atlas of tauopathy highlights pervasive overlap with brain aging. rdcu.be/b7SMW
Parkinson’s Disease is clinically heterogeneous! Check out our two new manuscripts on (1) how best to quantify motor heterogeneity and (2) the potential contribution of genetic risk factors:
medrxiv.org/cgi/content/shor…
doi.org/10.1101/2020.06.26.1…
We are excited to have partnered with Jim Lupski’s group to explore the relative contribution of single nucleotide and copy number variants to Parkinson’s disease risk. Check out our first Neurology Genetics paper to learn the results! ng.neurology.org/content/6/5…
Which mouse model is the best match “transcriptolog” for Alzheimer’s disease gene expression signatures in the human brain? You may be surprised! cell.com/cell-reports/fullte…
Our first eLife paper examines retromer mechanisms of brain aging and neurodegeneration--synaptic and lysosomal disruptions relevant for Alzheimer's and Parkinson's disease! elifesciences.org/articles/5…
RNA may not tell the whole story. . . Paired, longitudinal transcriptomes and proteomes in tauopathy reveal signatures of altered aging in neurodegeneration. New preprint: biorxiv.org/content/10.1101/…
In familial Parkinson’s disease, if you’re not looking for copy number variants, you may be missing out! Check out our new preprint on integrated analyses of exomes & aCGH: biorxiv.org/content/10.1101/…
ShulmanLab retweeted
WOW - @MichaelJFoxOrg supported PPMI data shows evidence of subtle motor & non-motor signs of #Parkinsons in non-manifesting carriers compared with healthy controls that can precede DAT deficit. Longitudinal data now essential to confirm these findings
thelancet.com/journals/laneu…
ShulmanLab retweeted
journals.plos.org/plosone/ar…
$1.1B wasted annually, completely shocked but not surprised in the slightest. Evidence that we should judge scientists by community resources created not certain semi-arbitrary and 'game-able' metrics. 🤯