@LabSaltiel
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Joined August 2020
- Tweets217
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Saltiel lab retweeted
Thrilled to share that I’ve been awarded an NIH K99/R00 Pathway to Independence Award from NIDDK!
I’m incredibly grateful to my mentor, @LabSaltiel, for his unwavering guidance & support. Excited to continue exploring mitochondrial biology in adipose tissue and metabolic health.
Saltiel lab retweeted
New @Nature research article: dietary cholesterol not only raises LDL—it activates RAS→Ral signaling, driving LDLR internalization and CTSA-mediated lysosomal degradation, independent of PCSK9. Blocking CTSA restores LDLR and cuts circulating LDL in mice. nature.com/articles/s41586-0…
Still a lot to learn about the Ral G proteins.
Nature research paper: Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover
go.nature.com/4w4aVes
How long-term dietary cholesterol can slow down its own clearance by liver cells nature.com/articles/d41586-0…
Thanks to Dan Rader for the nice comments about our paper.
Investigational Drug Could Control Cholesterol today.ucsd.edu/story/investi…
latest from star postdoc Xue Feng. Our continuing effort to explore the biology of Ral proteins.
really nice work. Glycogen plays an important regulatory role in many cells.
Neuronal glycogen powers anticipatory brain responses to food dlvr.it/TSlMGK
Saltiel lab retweeted
Behind the scenes with first author Churaibhon Wisessaowapak as she prepares Western Blot samples.
Saltiel lab retweeted
How does caloric restriction reduce energy expenditure while preserving energy storage?
doi.org/10.1172/jci.insight.…
Alan R. Saltiel @LabSaltiel & team @UCSanDiego show TBK1 acts as a brake on fat burning during fasting—and the combination of a TBK1 inhibitor and an AMPK activator reverses obesity and improves #MetabolicHealth in mice.
The figure: Combined TBK1 inhibition and AMPK activation improve metabolic health in obese mice.
Saltiel lab retweeted
Tomorrow (5/12), join us for the 2026 Saltiel Life Sciences Symposium: Decoding #GLP1s.
View the full schedule, including a poster session featuring U-M research:
lsi.umich.edu/events/2026-05…
Join us May 12 for the 2026 Saltiel Life Sciences Syposium: Decoding GLP-1s!
This full-day event will explore the fundamental cellular mechanisms behind the new generation of hashtag#GLP1 therapeutics, as well as ongoing efforts to improve them.
Speakers include @AmberAlhadeff, @DanielJDrucker, @TimoMueller_IDO, Martin Myers, @tunepers , @seeleyrj and @thewilliamslab
ALT scientific icons stylized as hieroglyphics with text: Decoding GLP1s: The science and circuitry behind new anti-obesity drugs
Saltiel lab retweeted
Dr. Irfan Lodhi and collaborators identified a pathway that regulates how the body breaks down fat during metabolic stress, including severe illness and cachexia, revealing insight into how stable fat stores are mobilized under stress conditions. bit.ly/3OVi7d7
will be great to get back to Ann Arbor for this meeting.
Join us May 12 for the 2026 Saltiel Life Sciences Syposium: Decoding GLP-1s!
This full-day event will explore the fundamental cellular mechanisms behind the new generation of hashtag#GLP1 therapeutics, as well as ongoing efforts to improve them.
Speakers include @AmberAlhadeff, @DanielJDrucker, @TimoMueller_IDO, Martin Myers, @tunepers , @seeleyrj and @thewilliamslab
ALT scientific icons stylized as hieroglyphics with text: Decoding GLP1s: The science and circuitry behind new anti-obesity drugs
UC San Diego Professor Elected to American Academy of Arts today.ucsd.edu/story/ucsan-d…
As several of my friends have commented, standards seem to have slipped.
Sad news. Such a sweet guy. Always positive and supportive, a serious scholar and terrific leader. He'll be missed.
A gentleman and scholar, leader in #islet biology, Editor of @Diabetes_ADA Professor Gordon Weir @Harvard @AmDiabetesAssn @JoslinDiabetes legacy.com/us/obituaries/nam… March 27 2026
Saltiel lab retweeted
With great sadness I report the passing of my scientific mentor Jesse Roth at age 91. Jesse was a brilliant & innovative scientist who led the field of membrane receptor biology from NIH diabetes branch. A small part of that family tree is shown. May his memory be a blessing.
Kvelling again about a former trainee. Xiao-wei Chen in another major breakthrough in Nature. Beautiful paper.
Nature research paper: CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis
go.nature.com/4rzQTXg
Very proud of my former trainee Shannon Reilly @ShannonReilly5. An exciting new look at thermogenesis.
Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes dlvr.it/TR6ggv
Meet the sixteen ASBMB members who were recognized for exceptional service and scientific impact across research, education, mentorship, outreach and leadership!
asbmb.org/asbmb-today/people…
#ASBMBMemberNews #Biochemistry #MolecularBiology #ASBMBFellows
Meet the 2026 ASBMB Fellows
Sixteen members were recognized for exceptional service and scientific impact across research, education, mentorship, outreach and leadership.
Join us in celebrating them at #ASBMB26!
➡️ Learn more about the 2026 fellows: asbmb.org/asbmb-today/people….
Saltiel lab retweeted
Today’s 📰#JEMjc @JExpMed highlights the work of
@LabSaltiel @UCSDMedSchool @Nature reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.
nature.com/articles/s41586-0…
the next chapter in our investigation into how glycogen metabolism is regulated in fat cells; terrific work from Haipeng Fu and our collaborators.
Happy to share our paper is now published in @NatureComms. This work studies transcriptional regulation of glycogen metabolism genes in adipocytes. Grateful to my mentor @LabSaltiel and all collaborators for their guidance and support. nature.com/articles/s41467-0…