@LabPuhar

We study infection and inflammation in the gut with focus on the endogenous danger signal extracellular ATP.

 Belfast, UK and Umeå, Sweden
mims.umu.se/groups/andrea-puhar.html
Joined February 2020
  • Tweets606
  • Following254
  • Followers409
29Media
Our new paper is out! We show that mechanical detection of bacterial entry by a mechanosensitive plasma membrane channel triggers ATP secretion and immune gene expression. Thus, physical signals can initiate the immune response to infection 🧵 doi.org/10.1016/j.celrep.202… @CellReports
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PhD position in a great lab:
Gunnar Schroeder@gunnar_ns11 Mar 2025
Funded 4-year #PhD in the exciting BBSRC NILAB program. @WWIEM_QUB Receive multidisciplinary training, develop #infection models and #AI image analysis to reveal bacterial & viral disease mechanisms & discover new antimicrobials. Fight #AMR Get in touch! tinyurl.com/e5k6ptua
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📣 Job Alert: Exciting Career Opportunities at MIMS! 🌟 Join us at the Swedish node of @NordicEMBL , @mims_umea, @umeauniversity! We're hiring: Group Leader in Infection Medicine, several Postdoctoral Researchers, and Project Administrator (event focus). umu.se/en/mims/career-and-ed…

Work With Us

umu.se
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We're looking for an Assitant Professor in Microbiology to join us @tcdgenmicro! Come and join our growing team. tcd.ie/microbiology/research… tcd.ie/hr/vacancies/ Job ID: 037876. Closes 31st January
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Sophie is spreading her wings soon!
Sophie Tronnet@sophietronnet21 Nov 2024
I enjoyed sunny Marseille at the #IM2B Scientific Day! Thrilled to announce that in Feb 2025, I’ll join Aix-Marseille University as Junior Professor Chair in microbiology, focusing on bacterial responses to complex environments. Stay Tuned!
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1/8 Publication Alert! Delighted to share the publication of a collaboration by Gerben Marsman (@zychlinsky lab @mpiib_berlin) and @xuhui_zheng (former PhD student in my lab) et al detailing how Histone H1 kills MRSA (cell.com/cell-reports/fullte…).

Histone H1 kills MRSA

Marsman et al. detect histone H1 in MRSA in human abscesses and demonstrate that it kills MRSA under physiological conditions. They identify through selective evolution and a genome-wide screen that...

cell.com
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Puhar Lab retweeted
Abcam
@abcam12 Nov 2024
Replying to @InflammaZoom
@InflammaZoom, the free webinar series for #innateimmunity and #inflammasomebiology researchers, returns November 21 with talks from Serge Mostowy @LSHTM @mostowylab and @PrajwalGurung @uiowa. Register here to join us: events.abcam.com/AnYVL?rt=Ql…
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We were in for a treat with fantastic talks from Bärbel Stecher @baerboletta, Santiago Castillo Ramirez @ccg_unam and Andreas Bäumler @abaumler at the Fraser Symposium in Infection Biology yesterday @WWIEM_QUB @QUBelfast. Thanks so much for visiting and sharing your work with us!
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Great local contributions with posters from our PhD students and postdocs, welcome by @CharuThakar, and talks from @ValvanoMiguel, @DavidCourtney89, Aurélie Mousnier, @josebengoechea, @Rebecca_Coll, @LabPuhar, @cisneros_lab, @gunnar_ns, and Timothy Shaw.
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Antibacterial compounds against non-growing Uropathogenic Escherichia coli identified via an HTS by the Chemical Biology Consortium Sweden, @umeauniversity. Led by the Tenson lab @unitartu, contributions from @LabPuhar and us at @lunduniversity. biorxiv.org/content/10.1101/…

Antibacterial Compounds Against Non-Growing and Intracellular Bacteria

Slow- and non-growing bacterial populations, along with intracellular pathogens, often evade standard antibacterial treatments and are linked to persistent and recurrent infections. This necessitates...

biorxiv.org
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It's been great fun to participate in the EMBO Fellows meeting as a grown-up Fellow in the mentoring session. Very impressed with this cohort of nice people and their work!!
EMBO@EMBO28 Oct 2024
More than 100 @EMBOFellows are meeting in Heidelberg. The postdoctoral fellows present their research, attend a mentoring session, receive training on a variety of topics and more. #EMBOat60
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📢 #EESMicrobiology is now open for registrations! Explore cutting-edge topics in #microbiology and discover the new approaches and technologies that can revolutionise the field's future. Submit your abstract and register to participate!

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A great review on the "Loss of tolerance to dietary proteins: From mouse models to human model diseases" from SMI member Nadine Cerf-Bensussan: onlinelibrary.wiley.com/doi/…
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It is out! 🚨 Phosphorous-free bacterial lipids can switch between pro- and anti-inflammatory depending on context!🔬 #Immunology #LipidBiology @PelegrinPablo @inflammasomelab A big thanks to the reviewers and editors. It was a laborious but smooth process🥳
Cell Reports@CellReports27 Sep 2024
Ornithine lipid is a partial TLR4 agonist and NLRP3 activator dlvr.it/TDlKJF
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This preprint could be a candidate for the Ig Nobel prize (which always has some truth in it). Don't stop at the title, do read the abstract!
Ardem Patapoutian@ardemp30 Sep 2024
"Monkeys Predict US Elections" results: "All monkeys looked more at loser rather than winner pictures (Figure 1a), sometimes avoiding the winner altogether (Supplementary Figure 1a)." H/t Lisa Stowers. biorxiv.org/content/10.1101/…

Monkeys Predict US Elections

How people vote often defies rational explanation. Physical traits sometimes sway voters more than policies do–but why? Here we show that rhesus macaques, who have no knowledge about political...

biorxiv.org
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Come join our fun community! Reach out to us with any question on this exciting project
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Online now - the Review "The #InositolPhosphate signalling network in physiology and disease" from Seyun Kim, Rashna Bhandari, Charles Brearley, and Adolfo Saiardi. #InsP #PPInsP #kinase #phosphatase #cofactor #bridge Read it here 👉 authors.elsevier.com/sd/arti…
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Job Alert! The Aramburu Lab @mims_umea @NordicEMBL is looking for a postdoc. If you are interested in discovering new #microproteins in innate immune cells and have a background in computational or proteomics, Apply or contact me. umu.varbi.com/what:job/jobID…

Postdoktor i proteinforskning i medfödda immunceller

Institutionen för molekylärbiologi söker en postdoktor för en tidsbegränsad anställning på två år motsvarande heltid med start 1 december 2024 eller enligt överenskommelse. Aramburu-laborato

umu.varbi.com
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#France2030 [SAVETHEDATE] Le Laboratoire d’Excellence en Biologie Intégrative des Maladies Infectieuses Émergentes @IbeidLabex organise la conférence internationale "Adapting to Change : Emerging Infectious Diseases in a Shifting Climate" du 16 au 18 octobre 2024 @institutpasteur
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Wow!
Ivan Ahel Lab@IvanAhelLab8 Sep 2024
Our new paper demonstrating reversible ubiquitylation of DNA and RNA: embopress.org/doi/full/10.10…
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Thrilled to announce that we have a postdoctoral position available to join the lab and investigate persistent Shigella infection! Do reach out if interested! Deadline: October 3rd Link: shorturl.at/Ndx6X Please retweet! @kingsmedicine @KCLImmunoMicro
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