Small young (pico) immunology lab in @SapienzaRoma. PI is Silvia Piconese. In love with regulatory T cells. (Thanks to @daisychungart for the profile pic)

Rome
Joined January 2020
Tregs can choose between producing TNF or sensing TNFR2... and the two states are much different! See our latest story published in @EurJImmunol onlinelibrary.wiley.com/doi/…
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In summary, TNF-TNFR2 signal sustains Tregs not through a pure autocrine mechanism. Rather, two Treg subpopulations exist that preferentially express TNFR2 or TNF, which cooperate in enforcing Treg suppression.
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Huge thanks to all co-authors, institutions and funders! @SapienzaRoma @AIRC_it @istitutopasteur
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Journal club at the immunothrombosis lab in @SapienzaRoma @RoychoudhuriLab @Lucia96107702 @StefaniaBasili
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My expression says it all… What a wonderful discussion we had! Thank you @kallikourdis for this full immersion in a community of outstanding immunologists
Excellent seminar on Treg physiology and biology today by @LabPico at Humanitas; great data followed by a very stimulating and interactive discussion - on innate and adaptive immunity questions!
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Thank you @FabriMattei for inviting Ylenia Pacella @8yLeNia8 in this interesting workshop hosted by @istsupsan
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SIICA Mentoring Program for Postdoc: Call 2025 Why should you apply for the SIICA Mentoring Program for Postdocs? Check how the program helped Gianluca Ready to take the leap? Apply! Candidate yourself as a mentee here: bit.ly/3y0gDWg
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Happy to be part of this!
📌 Gremita la sala del @CnrNanotec a #Lecce. Concluso ieri il #Workshop “La medicina di precisione nelle malattie reumatologiche e infiammatorie croniche intestinali” 📸 la photo gallery… #ASL_Brindisi #ASL_Lecce @APMARR_ITALIA @amiciibd @EU_Commission @mur_gov_
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Today @AlessandraPinz3 presented the results of her #PhD project at the #ECI2024 congress Well done Alessandra 👏🏻
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🔵 I'm blue da ba dee da ba di 🔵 Our Perls Prussian blue staining on the cover of @JCI_insight insight.jci.org/9/15
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Time to celebrate!
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Our study "Iron capture through CD71 drives perinatal and tumor-associated Treg expansion" has just been published in @JCI_insight! insight.jci.org/articles/vie…
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Our data indicate that the same metabolic route (based on #iron usage) can be both beneficial (perinatally) and detrimental (in tumor), when Tregs expand. And, through that route, Tregs may impact #ironstatus at the tissue and organismal level
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This study has been conducted @SapienzaRoma by @8yLeNia8 and the #Picolab, with the invaluable support of incredible collaborators! Thanks to @ClaudioTripodo @SciumeLab @valerioiebba and those not on X. Nothing would be possible without the support of @AIRC_it!
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