@LabPHB

Physical Biology of cells & multicellular systems (theory×exp). Chirality, Polarity, Mechanics, Morphogenesis, Collectivity. RIKEN BDR PI @TatsuoShibata25

 兵庫 神戸市 中央区
phb.riken.jp
Joined December 2025
  • Tweets26
  • Following69
  • Followers70
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Lab for Physical Biology (RIKEN BDR): theory×experiment on cells & multicellular systems, chirality, polarity, mechanics, morphogenesis, collective behaviors, active matter. 理研BDR フィジカルバイオロジー研究チーム：細胞・多細胞の物理生物学. 論文・連絡先: phb.riken.jp

PHB | Home

Explore the Laboratory for Physical Biology's research in cellular dynamics and theoretical models in Kobe, Japan.

phb.riken.jp
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研究室のメンバーの荻田くんがACT-X「生命と情報」に採用されました。おめでとう！今後のますますの発展を期待！
Goshi Ogita@GoshiOgitaSep 17
おかげさまで、ACT-X「生命と情報」領域に採択していただきました！一生懸命頑張ります！
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Lab for Physical Biology, RIKEN retweeted
Tomoki Ishibashi, Ph.D@TomokiIshibashiAug 17
生命のキラリティ研究会に行って参ります... I’ll be attending the FEBS Workshop “Biochirality across scales” in Nice this week! I’ll be talking about the mechanical principles that bridge cellular and multicellular chirality. biochirality2026.febsevents.… #Biochirality #FEBS
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Our paper is online! doi.org/10.1098/rsif.2026.00… How do invisible mechanical forces deform epithelial tissues during morphogenesis? @GoshiOgita developed Kalman-filter force inference (KFI), extending Bayesian force inference to infer dynamic cellular forces from time-lapse data.
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研究員の募集 細胞や組織のメカニクスで生まれる生命の秩序に関する理論的研究(riken.jp/careers/researchers…) 細胞や組織のメカニクスに実験的にアプローチ。特に、細胞や多細胞のキラリティ・左右非対称性に関わる研究。(riken.jp/careers/researchers…) ご興味のある方はお問い合わせください
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Open research position in my group at RIKEN BDR, Kobe, Japan. We seek candidates with a strong background in theoretical biophysics/modeling to study cell and tissue mechanics through close interaction with experiments. Details: riken.jp/en/careers/research…
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Our paper is now online! How can we describe active agents—filaments and cells—on curved surfaces? How does curvature affect their collective behavior? We develop a simple geometric framework and show that flocking depends on curvature heterogeneity. doi.org/10.1103/mxgg-9w4l
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Congratulations, Kyogoku-san and Kitajima-san! We are happy to have contributed a theoretical model that helps explain their data on nuclear volume growth.
理化学研究所（理研）@RIKEN_JPApr 30
命の始まりは父母ゲノムの「別居」から －父母ゲノム間の競合が受精卵の発生を助ける－ doi: doi.org/10.1038/s41586-026-1… 詳細はこちらをご覧ください⬇️ riken.jp/press/2026/20260430… #理研プレス

Cytoplasmic competition between separate parental pronuclei in zygotes

Nature - Drug-based and manipulation-based strategies provide evidence of pronuclear competition for finite cytoplasmic resources between separate parental pronuclei in zygotes, suggesting a cell...

nature.com
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New preprint: How is multicellular handedness determined? The same cell chirality can produce opposite multicellular handedness. Just as a car move forward or backward from the same engine rotation. By @TomokiIshibashi, et al. doi.org/10.64898/2026.04.04.…
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It was great to host Robin Bölsterli, a PhD student from the Niels Bohr Institute at the University of Copenhagen. He shared his ongoing collaborative work with Hirashima-san (@hirashima0203), and we had a great discussion.
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We also contributed.
RIKEN BDR@BDR_RIKENFeb 27
Replying to @BDR_RIKEN
The study by Yan Chen, @LabPhng and collaborators was published in @NatureComms. Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel constriction. doi.org/10.1038/s41467-025-6…

Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel...

Nature Communications - Dysregulation of blood vessel size can cause vascular malformations. Here, the authors demonstrate that endothelial cells generate circumferential actomyosin cables to...

nature.com
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Lab for Physical Biology, RIKEN retweeted
理化学研究所（理研）@RIKEN_JPFeb 26
【オンライン開催📢】 大学院進学希望の皆さん、#連携大学院 の学生として理研で研究してみませんか？ 理研生命機能科学研究センター(BDR)で、「連携大学院研究室見学会」の参加者を募集中です。 開催日時：4月11日(土)13:00～ 参加方法、詳細⬇️ riken.jp/pr/events/lectures/…
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Tatsuo @TatsuoShibata25 will speak at the upcoming EMBL symposium! Looking forward to great discussions on collective behavior in living systems. 次回のEMBLシンポジウムで講演します。生命システムのcollectivityについて議論できるのを楽しみにしています！ #EESCollectivity @EMBLEvents
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We hosted Prof. Stephan Grill (@StephanGrill; MPI-CBG Dresden, @mpicbg, @PoLDresden) for a BDR seminar (@BDR_RIKEN) on Feb 12, followed by a full day of discussions. Thank you, Stephan, for a fantastic talk!
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『現代化学』(@tkd_pbl) 2026年1月号の「FLASH」に寄稿しています。山本さん(@takaki_yamamoto)・石橋さん(@TomokiIshibashi)の論文の紹介です。
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Lab for Physical Biology, RIKEN retweeted
Phys.org
@physorg_com23 Dec 2025
#Molecular #Chirality in cytoskeletal proteins drives cellular rotation, offering new insight into how left–right asymmetry emerges in tissues and organs from the molecular to the cellular level. @riken_en @elife doi.org/hbgmcb phys.org/news/2025-12-chiral…

Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton

Molecular chirality of actomyosin induces cell-scale chiral rotation without requiring a chiral arrangement of actomyosin filaments, revealing a key mechanism of cell chirality underlying left–right...

elifesciences.org
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【arXivプレプリント】細胞やタンパク質が曲面上を動き、集団として秩序化する過程を記述する幾何学的フレームワークを提案しました。曲率とアクティブエージェントのダイナミクスを結び付けます。doi.org/10.48550/arXiv.2512.… #ActiveMatter

A geometric framework for curvature-dependent collective behavior...

In biological systems, active agents such as actomyosin and cells move and interact on curved surfaces, exhibiting diverse phenomena. These observations have motivated studies of how curvature...

arxiv.org
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New arXiv preprint: I develop a geometric framework to describe how cells and proteins move and collectively organize on curved surfaces, linking curvature to the dynamics of active agents. doi.org/10.48550/arXiv.2512.… #ActiveMatter

A geometric framework for curvature-dependent collective behavior...

In biological systems, active agents such as actomyosin and cells move and interact on curved surfaces, exhibiting diverse phenomena. These observations have motivated studies of how curvature...

arxiv.org
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【bioRxivプレプリント】Kalman-filter Force Inference（KFI）：上皮形態形成のタイムラプス・イメージングデータから、細胞の力（細胞間接着の張力と細胞圧）を動的にベイズ／カルマンフィルターの枠組みで推定します。doi.org/10.64898/2025.12.19.… #Mechanobiology #Morphogenesis
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New bioRxiv preprint: Kalman-filter Force Inference (KFI) estimates dynamic cellular forces (junction tensions and cell pressures) from time-lapse data of epithelial morphogenesis using a Bayesian/Kalman framework. doi.org/10.64898/2025.12.19.… #Mechanobiology #Morphogenesis
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プレプリント:連続供給のある“開放系”で、Dictyostelium KI細胞がcmスケールの多腕スパイラル（時計回り）を形成。実験＋開放系キラルVicsekモデルにより、微弱な単細胞キラリティと供給フラックスが巨視的キラル秩序を生む原理を示します。 doi.org/10.48550/arXiv.2511.…  #ActiveMatter

Emergence of chiral multi-armed spirals in an open system of...

Chirality organize living and active matter systems into striking collective states, yet the principles that govern chiral ordering in open systems, where elements are continuously added or...

arxiv.org
Lab for Physical Biology, RIKEN@LabPHB29 Dec 2025
New preprint: Chiral multi-armed spirals emerge in migrating cells under continuous supply. Experiments (Dictyostelium KI)+ an open chiral Vicsek model show how weak single-cell chirality + continuous supply generate macroscopic chiral order. doi.org/10.48550/arXiv.2511.… #ActiveMatter
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