@LabJanda

Student run Twitter account for the lab of Prof. Kim Janda @ScrippsResearch. Follow for updates on current research in our group!

 La Jolla, San Diego
scripps.edu/janda
Joined July 2020
  • Tweets24
  • Following9
  • Followers105
1Media
Earlier this year we published our approach using a catalytic antibody to not only sequester carfentanil, but inactivate it. Ming will be presenting this paper along with other great work he has done at his defense in September! pubs.acs.org/doi/10.1021/acs…

Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression

Abstract. Carfentanil, the most potent of the fentanyl analogues, is at the forefront of synthetic opioid-related deaths, second to fentanyl. Moreover, the

pubs.acs.org
8
1,254
Happy Friday from the Janda Lab 🍻 margaritas and pizza anyone?
10
#Hybridoma screening, #pharmacokinetics and #pain tests enabled Kim Janda’s team at @scrippsresearch develop a monoclonal #antibody against #heroin in mice. genengnews.com/topics/drug-d…

Heroin Antibody Fares Better than Earlier Therapies That Targeted Its Metabolites

A monoclonal antibody against heroin (11D12) is effective in blocking the euphoric and lethal effects of this much-abused opioid. The current findings clarify the reasons underlying the failure of...

genengnews.com
2
2
Our latest work showcasing a promising opioid immunopharmacotherapy and how it can help shift trends in vaccine development.
ACS Central Science@ACSCentSci
13 Oct 2022
NEW #ASAP Therapeutic monoclonal antibody for heroin abuse/overdose by @LabJanda shows vaccines have been mistargeting heroin’s metabolites for decades and should refocus efforts on heroin itself. Read here: go.acs.org/2tG
2
13
Collaboration with Prof. Andrianov at the University of Maryland showed PCEP to be a promising adjuvant for anti-drug vaccines. When hapten design is already optimized, finding new adjuvants for intranasal immunization is the way to go. Check it out here: pubs.acs.org/doi/10.1021/acs…

Polyphosphazene: A New Adjuvant Platform for Cocaine Vaccine Development

Abstract. Cocaine is a highly addictive drug that has seen a steady uptrend causing severe health problems worldwide. Currently, there are no approved ther

pubs.acs.org
2
Check out our latest paper: Identification of Slow-Binding Inhibitors of the Botulinum Neurotoxin Protease pubs.acs.org/doi/10.1021/acs… Congrats Ealin!

Identification of Slow-Binding Inhibitors of the BoNT/A Protease

Abstract. Botulinum neurotoxin A (BoNT/A) is a lethal toxin, which causes botulism, and is categorized as a bioterrorism threat, which causes flaccid paral

pubs.acs.org
2
6
Our most recent publication in JMC: A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than Fentanyl pubs.acs.org/doi/10.1021/acs… Congrats Jinny and Hyeri!

A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than...

Abstract. New psychoactive substance (NPS) opioids have proliferated within the international drug market. While synthetic opioids are traditionally compos

pubs.acs.org
2
During National Immunization Awareness Month (August 2021), we congratulate Dr. Kim D Janda of Scripps Clinic and Research Institute -- Recognized as an Expertscape Expert in Synthetic Vaccines. expertscape.com/ex/vaccines%…
1
2
Our lab recently published a potential therapeutic for the synthetic cannabinoid PB-22. Congrats Ming! pubs.acs.org/doi/10.1021/acs…

Pharmacokinetic Approach to Combat the Synthetic Cannabinoid PB-22

Abstract. Synthetic cannabinoids are part of a group of drugs called new psychoactive substances. Most of these cannabinoids are unregulated, and there are

pubs.acs.org
1
Salicylanilides as a promising therapeutic for COVID-19? Check out our latest paper to read more about it! pubs.acs.org/doi/10.1021/acs…

Salicylanilides Reduce SARS-CoV‑2 Replication and Suppress Induction of Inflammatory Cytokines in a...

Abstract. SARS-CoV-2 virus has recently given rise to the current COVID-19 pandemic where infected individuals can range from being asymptomatic, yet highl

pubs.acs.org
2
Check out a synthetic fluorescent MYC probe we found and how we developed a high-throughput screening assay that found a promising lead compound. sciencedirect.com/science/ar…
1
5
A new paper from our lab is out on Chemrxiv that used structure-based drug design as a way to develop inhibitors of botulinum neurotoxin A protease. Congrats @LewisTu52514415 and @alexanderln91! doi.org/10.26434/chemrxiv.14…

Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A...

We have used crystal structures and molecular modeling to evaluate inhibitor binding modes and design a series of compounds to take advantage of a new, cryptic, hydrophobic sub-pocket. This is a...

chemrxiv.org
1
3
Our recent publication on irreversible bifunctional inhibitors of botulinum neurotoxin A is out in RSC Med Chem, check it out! Congrats @LewisTu52514415 and @alexanderln91 🥳 pubs.rsc.org/en/content/arti…

Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunct...

Botulinum neurotoxin A (BoNT/A) is categorized as a Tier 1 bioterrorism agent and persists within muscle neurons for months, causing paralysis. A readily a

pubs.rsc.org
1
3
9
Here is our original proof of concept for this recent publication! pubs.acs.org/doi/10.1021/acs…

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

Abstract. Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them.

pubs.acs.org
2
Check out our latest work on an improved dual hapten vaccine for fentanyl-contaminated heroin! sciencedirect.com/science/ar…
4
Congrats to Lisa on the paper published today on two synthetic opioid vaccines! It not only elicits high-affinity antibodies against carfentanil and fentanyl, but also offers protection against opioid-induced respiratory depression. pubs.acs.org/doi/10.1021/acs…

A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory...

Abstract. The opioid epidemic remains a dire public health crisis with millions of people currently suffering from opioid use disorder (OUD) and tens of th

pubs.acs.org
6
We're excited to share our latest work on the first broadly neutralizing vaccine for synthetic cannabinoids in JACS Au! pubs.acs.org/doi/10.1021/jac…

Broadly Neutralizing Synthetic Cannabinoid Vaccines

Abstract. Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming a major public health risk. Due to the wide vari

pubs.acs.org
1
6
Happy to share our latest work on bifunctional covalent inhibitors of Botulinum Neurotoxin in JMedChem! pubs.acs.org/doi/10.1021/acs…

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

Abstract. Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them.

pubs.acs.org
1
1
7
We are features in the latest issue of Newsweek.
Scripps Research
@scrippsresearch
13 Aug 2020
"The complexity of brain chemistry involved is extremely difficult to target with a drug. But if you have a good enough #antibody, it acts like a vacuum cleaner to suck the drug out of the brain." Prof. Kim Janda's immunopharmacotherapy for #addiction newsweek.com/2020/08/14/how-…
1
3
"The complexity of brain chemistry involved is extremely difficult to target with a drug. But if you have a good enough #antibody, it acts like a vacuum cleaner to suck the drug out of the brain." Prof. Kim Janda's immunopharmacotherapy for #addiction newsweek.com/2020/08/14/how-…
4
1
8
Load more