We are interested in how nutrient, and metabolism affects stem cells and tumours
Melbourne, Australia
Joined August 2018
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Cheng Fly Lab retweeted
🧠 New research shows the blood–brain barrier helps control #braintumour growth.
Led by Prof Louise Cheng in @LabFly , the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.
Read more: petermac.org/about-us/news-a…
Cheng Fly Lab retweeted
Come and join us! We are looking for a bioinformatician to join the lab. Work with single cell, multiome and spatial data from model systems and human samples! Our focus is lymphatics and blood brain barrier in development, regeneration and cancer.
seek.com.au/job/79558172
Congratulations @khanh_ng97 on the ECR publication prize @AusFly2024 for elifesciences.org/articles/9…
Great having you in Melbourne, what a nice time we had with you and @Hina_kosakamoto
Cheng Fly Lab retweeted
Our latest from @TheCrick …
Sebastian Sorge led on this amazing new chemically defined (holidic) diet for fast larval growth & development in Drosophila. It’s called HoldFast, soon to be available to the community, in powdered form, from @VDRC_flies.
biorxiv.org/content/10.1101/…

It was a privilege to appear on @RRR to talk about our research and discuss what patients should know about cancer cachexia - a metabolic wasting disease affecting cancer patient outcomes. Grateful to our consumer Sudhir Sakhuja and my clinical collaborator @HyunKoMD.
"Cancer cachexia" affects 30% of cancer patients - 80% for advanced cancers - and yet few have heard of the term. Assoc Prof Louise Cheng (@LabFly), @HyunKoMD and cancer survivor Sudhir, have explained this muscle wasting condition to @3RRRFM.
Listen: rrr.org.au/shared/broadcast-…
Cheng Fly Lab retweeted
Paper is out! Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling | Sci Adv science.org/doi/10.1126/scia…
Kudos to super talented lab members @LukeKunYangLin1 @mahekta @jiaen_lin @GaoYang43766353 and wonderful collaborators @Yusuke_Toyama & Tony
Cheng Fly Lab retweeted
We are excited to announce the next Workshop on Neural Circuits & Behavior of Drosophila that will be held at the Orthodox Academy of Crete (OAC), Kolymbari, from June 15-21, 2025. Please RT.
Cheng Fly Lab retweeted
Missing our @FlyJedi meetings? The #JEDI are back for great #Drosophila science! Follow us for more news and dates! #thereturnofthejedi
Cheng Fly Lab retweeted
Very excited to share our #preprint in @biorxivpreprint in which we found that the transcription factors of JNK and Hippo pathways control epithelial integrity by regulating an overlapping transcriptome 🧵1/10
The JNK and Hippo pathways control epithelial integrity and prevent tumour initiation by regulating an overlapping transcriptome biorxiv.org/cgi/content/shor… #bioRxiv
As the Drosophila OL shares a similar mode of division with mammalian neurogenesis, understanding when and how these progenitors cease proliferation during development can have important implications for mammalian brain size determination and regulation of its overall function.
The termination of medulla NBs during early pupal development is determined by the exhaustion of the NE stem cell pool made during larval development. Hence, altering NE-NB transition during larval neurogenesis disrupts the timely termination of medulla NBs.
In the Drosophila optic lobes, medulla NBs derived from the neuroepithelium give rise to neurons and glia cells of the medulla cortex. In this work, we demonstrate medulla NBs terminate via a fail safe mechanism through cell death, differentiation and gliogenesis
A big thank you to the expert reviewers, and a fast and efficient process @ReviewCommons @eLife
Happy to share the latest work from the lab, led by our PhD student Khanh Nguyen @khanh_ng97
doi.org/10.7554/eLife.96876 @eLife
We thank the reviewers @ReviewCommons for expert reviews, fast turn-around and great suggestions.