Inner Ear Regenerative Medicine Lab for future treatment of hearing loss and balance disorders @Sunnybrook @UofT PI: Alain Dabdoub
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ALT IMAGE: In this microscopy image, dissection reveals the cochlear duct tightly coiled inside the developing inner ear, echoing the same logarithmic spiral seen in galaxies like the Whirlpool Galaxy.
ALT Postnatal day 0 wholemount stria vascularis stained with Phalloidin for actin (green), Lectin for blood vessels (magenta) and DAPI for cell nuclei (blue).
ALT On the left, anatomy illustration of the human inner ear. On the right, a plot demonstrating the heterogeneity of utricle sensory epithelium with two sensory hair cell clusters and six supporting cell clusters. More details in the manuscript.
ALT A SEM image of the cochlea
ALT Image showing the sensory epithelium of a human utricle with hair cell bodies labeled with #myosin (green), #HairCell nuclei labeled with the transcription factor POU4F3 (magenta) and DAPI for all nuclei (cyan).
ALT Postnatal day 30 cross section of a cochlear turn (A) and postnatal day 0 wholemount stria vascularis (B) stained with Phalloidin for actin (green), Lectin for blood vessels (magenta) and DAPI for nuclei (cyan). Orthogonal view of the wholemount SV in bottom panel of (B) marks nuclei of the three cell layers of the stria.
ALT Boaz working in the lab
ALT Confocal image of the luminal surface of the organ of Corti illustrating the uniform orientation of hair cell stereociliary bundles. Development of this planar polarity occurs during the late embryonic and early postnatal periods, and is regulated by Wnt signaling. Filamentous actin, including stereocilia, is labeled in green; acetylated tubulin, including the kinocilium located at the vertex of each stereociliary bundle, is labeled in red.
