Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem 👇👇👇

Our new study exploring the molecular principles governing packaging of eukaryotic mRNPs has just come out in @GenesDev . We find evidence for RNA packaging and compaction relying on positively charged IDRs of potentially many RNA binding proteins. Interested? Check it out!

Excited to share new work on the human CCR4-NOT complex: our analysis pinpoints the N-terminal CNOT1-CNOT10-CNOT11 module as a conserved interaction platform. We identified GGNBP2 - a tumor suppressor and spermatogenic factor - as a conserved binding partner. @MPI_Biochem

Great honour receiving the 2022 Aminoff Prize with Patrick Cramer and Seth Darst from King Carl XVI Gustaf of Sweden last week. Photo from KVA, Markus Marcetic. @vetenskapsakad @CramerLab @MPI_Biochem

Happy to share our work on the human NEXT complex which homodimerizes via two intertwined ZCCHC8 subunits. In order to transit from gatekeeping to activation mode the ZCCHC8 C-terminus is displaced, allowing the RNA 3′ end to access the human nuclear exosome for degradation.

Very much looking forward to this! lincei.it/sites/default/file…

Happy to share our work on the human SKI complex which adopts distinct conformational states to recognize and extract ribosome-bound RNA. These functional states regulate access of the RNA 3' end to the cytoplasmic exosome for co-translational degradation. Congratulations to all!

We are currently testing different protein staining solutions. It is unexpectedly difficult to remain objective... Any thoughts?

We finally made it! Very excited to discuss and share science with you. Stay tuned for news from the Conti lab @MPI_Biochem.