MD | Surgical & Anatomical Pathology | Digital Pathology & Translational Research🔬🦠🧫🩸🧬 #PathX #path2path #PathMatch
Joined June 2022
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Lisa Centeno retweeted
Beautiful example of two tumors in one : papillary RCC and acquired cystic disease–associated RCC forming a collision tumor.
One component shows tubulopapillary architecture (separate tumor 1.8 cm) with diffuse CK7 and AMACR expression.
The second shows both sieve-like microcysts, eosinophilic cells and calcium oxalate crystals; patchy CK7
Background kidney: End stage renal disease with cysts,
#DxMindMap #KidneyPath #GUPath #PathTwitter
🧩 Kidney riddle
One of my favorite case, a true diamond in all the treasures I have collected.
Let us start simple: how many tumors can we see?
#DxMindMap #KidneyPath #GUPath #PathTwitter @JHUpath
Lisa Centeno retweeted
#GUpath prostate bx:
nice example of "microcystic" pattern prostatic adenocarcinoma (still 3+3)
pathologyoutlines.com/topic/…
Lisa Centeno retweeted
Rare UC subtypes, two largest series to date, one message: morphology still predicts behavior.
🔬 Giant cell UC-nuclei ~12x larger than neighboring tumor cells, enriched for T3/4, worse OS PMID: 42252958
🔬 Lipid-rich UC-MDM2(+) could be a pitfall PMID: 42596534 @AJSPJournal
ALT GCUC
ALT Lipid Rich UCa
ALT MDM2 in Lipid Rich UCa
ALT GCUCa
Lisa Centeno retweeted
WHAT'S NEW IN NEUROENDOCRINE TUMORS (WHO 6TH EDITION 2026)
Presence of any nuclear labeling with Ki67 above background is considered positive
Ki67 stain is not a positive or negative stain. It is dynamically expressed throughout the cell cycle
Stronger Ki67 IHC assays tend to flatten this variation
Dr. Bellizzi GIPS pathcast youtube.com/live/o8IqIDiN_Jw… #pathology #PathX
Lisa Centeno retweeted
WHAT'S NEW IN APPENDICEAL TUMORS (WHO 6TH EDITION)
Both appendiceal mucinous adenoma and serrated polyp can be circumferential with intact muscularis mucosae
• Mucinous adenoma → tall mucinous cells, villous/flat
• Serrated polyp → serrated crypts
Loss of MM or mural fibrosis = LAMN
WHO 6th brings mucinous adenoma back; it was not a distinct category in the 5th edition
Dr. Pai GIPSPathcast youtube.com/live/sqSRogzCDf8… #pathology #PathX
Lisa Centeno retweeted
Prostatic stromal tumor of uncertain malignant potential (STUMP).
Variable morphology: This one show atypical stromal cells, some with degenerative change, proliferating around crowded, architecturally complex benign glands.
Common pitfall: BPH stromal nodules are bland and multinodular, with prominent thick-walled vessels.
Hypercellularity, marked atypia, increased mitotic activity, atypical mitoses, necrosis, or invasion favor prostatic stromal sarcoma; exclude other sarcomas and sarcomatoid carcinoma. Ref: WHO 5th ed. #DxMindMap #ProstatePath #GUPath #PathTwitter @JHUpath
🧩 Prostate riddle
Continue exploring a rare tumor in the prostate.
Which component appears neoplastic, spindle or epithelial?
What would you consider in the differential?
#DxMindMap #ProstatePath #GUPath #PathTwitter @JHUpath
Lisa Centeno retweeted
Excited and proud to share our special issue on #Leukemia that @ljmedeirosMD & I put together for @Human_Pathology We brought together incredible experts to write about the latest in the field.
13 articles, each one #hemepath GOLD💎! 1/14🧵
Starting with our intro to the issue sciencedirect.com/science/ar…
Lisa Centeno retweeted
The Swan Thung Memorial Liver Pathology Lecture Series continues on #pathCast.
🎙️ Dr. @SaxenaLiverPath from @EmoryPathology
📌 Hepatitis B, Dr. Thung, and I
📅 Aug 11, 2026
🕛 12 PM ET
🔴 Live: Facebook & YouTube
🌐 pathcast.net
#LiverPathology #HepatitisB
Lisa Centeno retweeted
🚨Diagnostic Pitfall Alert!!
When encountering extreme umbrella cell atypia, fusion of papillae within a tumor can convey a higher grade appearance #gupath😱 beware!
Lisa Centeno retweeted
🧩 Kidney riddle
Continuing our eosinophilic renal tumor series…
Along with Ting’s recent LOT post, xitter.cf/TingZhaoPathdoc/status…
Here is another TSC/mTOR pathway associated RCC.
What is your diagnosis?
#DxMindMap #KidneyPath #GUPath #PathTwitter @JHUPath
Lisa Centeno retweeted
The 6th edition of the WHO classification of tumours of the breast (2026) is now in use. Here is a comprehensive, well-illustrated, practical summary by a group of leading experts of the main changes since the last edition. #openaccess #breastpathology
doi.org/10.1111/his.70149
Lisa Centeno retweeted
The Swan Thung Memorial Liver Lecture Series continues with Lecture #2.
Join Dr. M. Isabel Fiel (@MountSinai_Path ) for “ When to Worry About Hepatocellular Adenomas?”
📅 July 24, 2026
🕛 12 PM ET
YT: youtube.com/pathcast
FB: facebook.com/pathcast
pathcast.net
Lisa Centeno retweeted
Publication spotlight 📣 Great Mount Sinai Pathology representation in the Diagnostic Histopathology mini-symposium, “Organ-Specific and Systemic Manifestations in Infectious Diseases." Now available online ahead of print! (2/2)
Lisa Centeno retweeted
5 Things Every Pathology Resident Should Know About Invasive Breast Carcinoma NST
2. The Nottingham grade
Histologic grade is determined using the Nottingham grading system, developed by renowned pathologists Drs. Ellis and Elston at the University of Nottingham in the UK.
It scores three features:
- Tubule formation
- Nuclear pleomorphism
- Mitotic count
The three scores are added:
3–5 = Grade 1
6–7 = Grade 2
8–9 = Grade 3
More than three decades after its introduction, the Nottingham grading system remains one of the most important prognostic tools in breast pathology.
#PathX #PathTwitter #breastpath
Lisa Centeno retweeted
Updates from the WHO Classification of Breast Tumors, 6th Edition (not published yet)
Mucin producing tumours of high nuclear grade, ER negativity and HER2 positivity are not classified as mucinous carcinoma, but as invasive breast cancer with mucin production.
Dr. Tan #USCAP #pathology #BreastPath #PathX
Lisa Centeno retweeted
Can AI help detect lymph node metastasis in gastric, colorectal, and breast cancer? Find out here 👉 doi.org/10.5858/arpa.2025-03…
#CAP #Archives #Pathology #AIinPathology
Lisa Centeno retweeted
Join the inaugural @pbpath - @pathologyCast Presentation!
(Dr. Chanjuan Shi, @DukeMedSchool)
Pancreatobiliary Neuroendocrine Neoplasms: Updates on the New WHO Tumor Classification
📅 June 30
🕘 9:00 AM PST
🎥 LIVE:
Facebook & YouTube: /pathcast
🌐 pathcast.net
Lisa Centeno retweeted
Lung - Lepidic pattern and micropapillary pattern can show as a ground glass lesion on imaging
That is why our job is to recognize the micropapillary pattern which is commonly missed (considered high grade, and any tumor with >20% of high grade component is considered poorly differentiated)
Even 5% of micropapillary or solid pattern is associated with worse outcomes
Classic micropapillary pattern (Pic 1)
Not so classic presentations of micropapillary pattern (pic 2)
Dr. Butt #JobPrepBootcamp #NIPCAP #pathology #PathX
Lisa Centeno retweeted
Look at these beauties lining up and posing for my camera
Monoblast ➡️promonocyte ➡️ mature monocyte.
With all the hype about #RAS I think they know the hemepath paparazzi is hunting for them 📸
Lisa Centeno retweeted
Peripheral smears
***Reactive lymphocytes vs blasts***
The most important criterion is chromatin.
Clumped chromatin: lymphocytes
Smooth chromatin: lymphoblast
Dr. Jain #JobPrepBootcamp #NIPCAP #pathology #PathX
