Bone and soft tissue, surgical and cytopathologist at University of Michigan | @UMichPath @UMichMedicine | T/RT not medical advice
Ann Arbor, MI
Joined March 2024
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Stomp Out Sarcoma Fun Run/Walk is tomorrow at 9 AM in Hudson Mills MetroPark, Dexter, Michigan, for anyone interested in a running event! Walk-up registration begins at 8 AM.
michiganmedicine.donordrive.…
Kyle Perry retweeted
Cleveland Clinic soft tissue pathology course starts in 7 days!! May 15-18. 150 digital cases. 15 sessions with staff. VIRTUAL option. Everything will be RECORDED and available on demand!!#PathTwitter na01.safelinks.protection.ou… @ClevelandClinic @CleClinicMD @CAPA_comm @ISBSTP @TheUSCAP
It’s gastric and spindled, but it’s not a GIST… Plexiform fibromyxoma is a benign tumor that presents as a multinodular intramural mass in the stomach. The nodules can be fibrous or myxoid and have a delicate capillary pattern. #BSTPath, #UmichPath, #BSTpathGoBlue
The spindled morphology and plexiform architecture can sometimes cause these tumors to be mistaken for (SDH-deficient) GIST. Unlike GIST, these tumors are negative for CD117 and DOG1.
Nice review article by Szczepanski, Westerhoff and Schechter on this rare entity (pubmed.ncbi.nlm.nih.gov/3974…)
Kyle Perry retweeted
Over the past several years, we have seen several examples and now you can read about our experiences with these patients and the pathology of these unusual tophi.
journals.lww.com/ajsp/abstra… #bstpath #gout #pseudogout
Dealing with an unusual fibromyxoid spindle cell neoplasm (that is MUC4 negative)? Consider PLAG1! #BSTPath, #UmichPath, #BSTpathGoBlue
Some nice papers (Fritchie and colleagues/ Chung and colleagues) further elaborating on this entity(ies)….
pubmed.ncbi.nlm.nih.gov/3309…
pubmed.ncbi.nlm.nih.gov/3330…
I would highly recommend this course for anyone (regardless of level of expertise) looking for a comprehensive/case-based experience with bone and soft tissue. Dr. Fritchie and colleagues at Cleveland Clinic are excellent teachers. clevelandclinicmeded.com/liv…
ALK-positive histiocytosis of the breast is a rare tumor that can mimic other inflammatory neoplasms or processes, such as inflammatory myofibroblastic tumor, cellular spindled histiocytic pseudotumor (among others). #BSTPath, #UmichPath, #BSTpathGoBlue
Interestingly, the cells in this case also showed staining for OCT2, which has historically been associated with other histiocytic-type proliferations, such as Rosai-Dorfman disease, some Langerhans cell histiocytosis, and juvenile xanthogranulomas.
Nice article on ALK-positive histiocytosis of the breast: pubmed.ncbi.nlm.nih.gov/3282…
Cellular spindled histiocytic pseudotumor (often of the breast) can sometimes be confused for inflammatory myofibroblastic tumor. The spindled cells exhibit irregular grooved nuclei which help suggest the tumor’s histiocytic nature. #BSTPath, #UmichPath, #BSTpathGoBlue
Nice article by Sciallis, Chen and Folpe describing this entity. pubmed.ncbi.nlm.nih.gov/2298…
Although not typically associated with a “round cell sarcoma” differential, solitary fibrous tumor can sometimes mimic small round cell type sarcomas such as Ewing sarcoma. #BSTPath, #UmichPath, #BSTpathGoBlue
ALT Sheets of "round blue cells" in a solitary fibrous tumor
ALT Tumor cells in this SFT showed cytoplasmic vacuolizatoin.
Nice article by Dermawan and colleagues on CD34-negative solitary fibrous tumors:
pubmed.ncbi.nlm.nih.gov/3415…