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Bad Apple but it's playing on a fly's brain
For the first time, scientists have mapped the complete brain and central nervous system of an adult male fruit fly — a key model organism in science. 🪰
Working alongside HHMI Janelia Research Campus and the scientific community, @GoogleResearch scientists and researchers used AI to combine millions of 2D images into 3D neural shapes, reconstructing a record-breaking 166,000+ neurons. This foundational map of the adult male fruit fly brain can help accelerate our understanding of the brain, and is a major milestone in neuroscience.
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A few months ago I started writing a Photoshop alternative built on a node graph. Mac and Windows, native C++, 74 nodes. Every operation is non-destructive. Paint, masks, warps, the whole toolset. Nothing bakes.
Launching Tuesday Apr 28. Want to beta test this week? Reply BETA.
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It’s official everyone!!
We’re thrilled to share the news that Cavalry is now free!
Download it and start creating today at cavalry.studio
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Hyvää 100-vuotissyntymäpäivää, Erik Bruun, Suomen ikonisin graafikko! Erikin työt ovat kauniita ja raikkaita kaikilla vuosikymmenillä.
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It's sort of cool when a crucial part of the global supply chain breaks down. You get to learn about how all kinds of different things are made
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there really is a "fix everything right now" button for buying a printer and its been the same for 20 years
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My best tip for anyone trying to get back into reading is to remember that you can read books to avoid other responsibilities in your life, and it can become a vice if you play your cards right.
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This is exactly right.
In our recent ADHD + Circadian review, symptom improvement occurred with 0.5 mg melatonin ~5 hours before bedtime to phase advance the clock.
Melatonin should be used to shift circadian phase, not as a sleeping pill.
xitter.cf/BrandonLuuMD/status/20…
Most people take melatonin right before bed.
That might be one of the worst times to take it.
Melatonin isn't a sedative, it's a chronobiotic. It doesn't knock you out. It signals to your circadian clock that it's dark. And the effect it has on your sleep timing depends entirely on WHEN you take it.
There's a concept called the Phase Response Curve. It shows that melatonin taken ~3 hours before your usual bedtime produces the largest phase advance, meaning it shifts your internal clock earlier, so you fall asleep sooner and wake up easier.
But take it AT bedtime? You can actually push your clock in the wrong direction. That's a phase delay. You end up falling asleep later over time, not earlier.
The sweet spot sits just before dim light melatonin onset, the point when your brain would naturally start releasing melatonin. For most people, that's roughly 3 hours before habitual bedtime.
Timing > dose.
Lewy et al. (1998), Burgess et al. (2010), and Challet et al., J Pineal Res (2024).
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Did you know Hokusai published 3 volumes of art instruction on simplification?
Which means we can study instructional drawings from one of the most renowned artists in history
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Are people still doubting gaussian splatting fidelity?
Interactive from William Beck on @playcanvas: superspl.at/view?id=5c0f892e
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The first line of Knausgard's 'My Struggle' is the best first line we have in modern fiction:
“For the heart, life is simple: it beats for as long as it can.”
Fun computer fact: in binary data streams, zeros don't convey information and are included solely for padding purposes. They can be removed to make files smaller, then inserted back if a particular program requires padding for compatibility.
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Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching










































