Synthetic Methods and Natural Product Synthesis @ UT Austin
Austin, TX
Joined January 2019
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Here, we report the first examples of alcohol-mediated nitrile reductive C-C coupling. Congrats to Sebastian, Colin and Weijia! doi.org/10.1002/anie.9880459
Many thanks to colleagues in Hokkaido for recognition of our work – and many thanks to students past and present for bringing it life! icredd.hokudai.ac.jp/akira-s…
Conjugation of phenyl and pyridyl bioisosteres via azole/azine C-H functionalization beyond premetalated reagents or photochemical promotions! doi.org/10.1021/acs.orglett.…
Metal-centered stereochemistry unlocks the mystery of halide counterion effects. Congrats to Connor, Ed and our collaborators Andrea and Stefan! doi.org/10.1021/acscatal.6c0…
Congrats to Weijia, Sebastian, Colin, Nick, Andrea and Prof. Gimme for discovering and understanding (via computation) this base-free alkynylation of fluoral where 1 of 12 diastereomeric-at-metal complexes dominates the kinetics of carbonyl addition. onlinelibrary.wiley.com/doi/…
The low aromatic stabilization energies of azoles/azines unlock a novel pathway for N-heteroaryl C-H functionalization via dearomative addition-hydrogen auto-transfer. Congrats to Nick, Brandon, Niclas, Vinnie, Sarah and Tate on this amazing reaction! pubs.acs.org/doi/10.1021/jac…
Chiral-at-metal-and-ligand catalyst unlocks enantioselective alkynylation that is air/water tolerant and base-free. doi.org/10.1002/anie.9580914
For long-term solutions, look beyond backward-facing approaches. doi.org/10.1021/acs.chemrev.…
Polyketide total synthesis reinvented! Congrats to Kate, Yoon and team Warwick! doi.org/10.1021/jacs.5c22672
A practical butadiene-mediated carbonyl crotylation after nearly 2 decades of work! doi.org/10.1021/acs.orglett.…
TexSyn-VII will be held May 29-30, 2026 at UT Dallas. Come see great synthetic chemistry from the Lone Star State, y’all! texsyn.org/
One more gem carved from chaos by Seoyoung, Sarah, Erin and Brandon. doi.org/10.1021/jacs.5c15097
Krische Lab retweeted
Great news! The deadline for poster presenters and attendees to register for the Women in Catalysis and Synthetic Chemistry Symposium has been extended to November 3rd. We hope to see y'all there!
Registration link: forms.gle/GKqfXG2UZkR2r1ySA
Hydrogen is the forward-facing choice for reductive cross-coupling. doi.org/10.1021/jacs.5c15725
Reminder that the third WCSC event is Nov 15th! Chemistry students in Texas are encouraged to register for the event and consider presenting a poster or speed talk. This event is FREE and will be a full day of networking and chemical insights! Hope to see you there!
It was our pleasure to welcome Prof. Daniel Werz of Freiburg University for a research seminar in Austin!
