@KriesLab

Biosynthetic Design of Natural Products et KriesLab et mstdn dot science

 Jena, Germany
leibniz-hki.de/en/biosynthetic-design-of-natural-products.html
Joined March 2019
  • Tweets201
  • Following245
  • Followers772
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Who decides product specificity in nonribosomal assembly line synthesis? The answer is important for making new antibiotics through #NRPS engineering. Now out @ACSCatalysis. bit.ly/3yeXuKH Thanks to our collaborators @david_niquille & J. Reinstein @mpi_mr_hd. @LeibnizHKI
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Yes, I think you should. The twitter crisis is a unique chance to build a better community for scientists on #Mastodon without ads and attention-hogging algorithms. #twexit nature.com/articles/d41586-0…

Should I join Mastodon? A scientists’ guide to Twitter’s rival

Nature - The open-source platform has added nearly half a million users in little more than a week — but should scientists make the leap? We examine the pros and cons.

nature.com
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Today we celebrate #WorldScienceDay for Peace and Development 🌍🦠💊🔬🧫🧪🧬 So we asked some of our researchers what motivated them to become scientists: @microverse_exc @LeibnizWGL @TRR_FungiNet @chembiosys_jena @Buettner_H @mgblango @KriesLab @zcseresn
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I love the idea of a free, open-source, and ad-free social network for scientists. I have just made a profile for our lab on @mstdn.science and so far it looks great. A nice community is building there right now.
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On bioRxiv: Adenylation multispecificity guided us to find broad evolvability of #nonribosomal surfactin synthetase SrfAC. Provides guidelines which enzyme residues have potential for bioengineering #antibiotics. Congrats Aleksa! @LeibnizHKI @SvenssonCarl bit.ly/3LqOJoD
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Just my yearly reminder: there is a standard format behind (probably) most published papers. I highly recommend all students look at that format: journals.plos.org/ploscompbi… makes writing easier for my students (and myself)

Ten simple rules for structuring papers

journals.plos.org
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Did you know that an artwork of Beuys once got mopped up by accident? Indiscriminate cleaning up of biosynthetic intermediates can be a loss or a benefit for engineered #NRPS as shown by Farzaneh&Sayan in ACS Chem Bio. @LeibnizHKI @KriesLab @Hertweck_Lab bit.ly/3B779qX
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In our institute, we pursue many different approaches to find new therapeutic agents. One cool way is Biosynthetic Design in @KriesLab and it's probably best we let Hajo Kries explain what that is himself:
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Happy to share the latest synthesis project: Total Synthesis and Functional Evaluation of IORs, Sulfonolipid‐based Inhibitors of Cell Differentiation in Salpingoeca rosetta onlinelibrary.wiley.com/doi/… @ERC_Research @TRR_FungiNet in collaboration @KriesLab @LeibnizHKI @Choano_Lab

Total Synthesis and Functional Evaluation of IORs, Sulfonolipid‐based Inhibitors of Cell Differen...

A new and modular synthesis of the rosette-inhibitor sulfonolipid IOR-1A and chemical probes was achieved via decarboxylative cross-coupling reaction of a desymmetrized tartaric acid derivatives and...

onlinelibrary.wiley.com
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Great collaboration between @Hertweck_Lab, Michael Groll @TU_Muenchen and @KriesLab funded by @chembiosys_jena, @tmwwdg und other sources
Leibniz-HKI@LeibnizHKI29 Jul 2022
Leibniz-HKI researchers from @Hertweck_Lab - in cooperation with @TU_Muenchen - have identified an enzyme that is a promising new therapeutic target to combat dangerous bacterial diseases caused by Burkholderia @felix_trottmann leibniz-hki.de/en/press-rele…

Melioidosis: New target to combat a dangerous bacterial inf…

Researchers at the Leibniz-HKI have identified an enzyme that is a promising new therapeutic target to combat the …

leibniz-hki.de
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Excellent opportunity for a PhD project between @andrecobb and my lab at King's College London: Using photoredox catalysis to manipulate posttranslational modifications! findaphd.com/phds/project/di…

Discovery of New Post-Translational Modifications using Photoredox Catalysis at King’s College...

PhD Project - Discovery of New Post-Translational Modifications using Photoredox Catalysis at King’s College London, listed on FindAPhD.com

findaphd.com
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Congrats Jacob Wurlitzer & Markus Gressler! We recorded substrate profiles in this exciting project on fungal #NRPS. Knowing side-activities helped to develop a biosynthetic strategy for fluorophore-labeled peptides. @LeibnizHKI @ChemicalScience @UniJena doi.org/10.1039/D2SC00860B
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KriesLab retweeted
SYBORG@erblabs14 Jul 2022
The morning after: Reading @BILD about #CO2 and our Science @mpi_marburg & @SYNMIKRO
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Biosynthesis of strychnine | Nature. Congratulations Benke. And thanks everyone for your help on this one. nature.com/articles/s41586-0…

Biosynthesis of strychnine

Nature - The biosynthetic pathway of strychnine, brucine and diaboline is described, and the biosynthesis of these complex, pharmacologically active compounds has been successfully recapitulated in...

nature.com
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We are looking for a Postdoc in Chemical Biology/Protein Semisynthesis to make new 'designer' p53. Please see link for details: jobs.kcl.ac.uk/gb/en/job/049…

Jobs at King’s College London | King's College London

Our vision is to make the world a better place through world-leading education, research and service.

kcl.ac.uk
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We are #hiring! The Helfrich lab is looking for a #postdoc with a background in #chemistry to study the #biosynthesis of non-canonical #naturalproducts! Join our team @goetheuni and @LOEWE_TBG in Frankfurt! More information: helfrichlab.com/team/open-po… Please share and RT!
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Happy to be at #DBVI with many fantastic talks and posters @KriesLab
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A fully-funded, 2-year master's student position (#Scholarship) in our group, azumag.com/open-positions. We are looking for applications from highly motivated students who are about starting master's study in #Krakow, and are interested in #Proteinengineering #Proteincage #Bionano.

Open Positions | Azuma group

azumag.com
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Faule und fleißige Zellen erkennen: Chemiker:innen der #UniLeipzig haben per #Mikrofluidik-Technologie eine Möglichkeit gefunden, die #Biokatalyse einzelner Zellen zu untersuchen. Das eröffnet ganz neue Möglichkeiten in der „Grünen #Chemie“. uni-leipzig.de/newsdetail/ar…
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Please share! Our young team of biosynthetic designers @LeibnizHKI (Jena, D) is looking for a postdoc with experience in handling RNA. Thanks to the Boehringer Ingelheim Foundation for the Exploration Grant. More info in the job offer below & upon request. bit.ly/3FhnNEO
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Join our great microfluidic team at the Bio Pilot Plant of the ⁦@LeibnizHKI⁩ jobs.hki-jena.de/jobs/Doctor…
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