@KoehnLab

Research group 'RBPs and ncRNAs in human disease', Charles Tanford Protein Center, Medical Faculty, University of Halle-Wittenberg

 Halle (Saale), Germany
Joined June 2023
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  • Following30
  • Followers36
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We offer a new PhD student position in the Ott/Köhn labs within the DFG-funded graduate school #RTG2467. It aims at elucidating the role of intrinsic disorder in nuclear proteins using biophysical and cell-biological techniques. verwaltung.uni-halle.de/deze…
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The latest work of the Koehn Lab is now available as preprint. 🥳 biorxiv.org/content/10.1101/… Outstanding work of @jaime_csanchez combing our expertise in RNA and protein function (@StefanHttelmai1 @SinzAndrea) with leukemia research (@Keeshanlab @VetrieLab)!

The long non-coding RNA FAM30A regulates the Musashi2-RUNX1 axis and is required for LSC function...

High expression of the long non-coding RNA (lncRNA) FAM30A has been previously associated with leukemic stem cell (LSC) activity and poor prognosis in both adult and paediatric acute myeloid leukae...

biorxiv.org
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APOBEC3C-mediated NF-κB activation enhances clear cell renal cell carcinoma progression 👉buff.ly/3Xl6m0I 🖊️@StefanHttelmai1 @KoehnLab #NFκB #ccRCC #RNAEditing #CancerBiology
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The latest study on how the RBP APOBEC3C promotes kidney cancer progression from the Köhn Lab is now online!!! febs.onlinelibrary.wiley.com… Many thanks to all researchers involved especially Nora Hase. #RTG2467 #FOR5433 @StefanHttelmai1 @unimedizinhalle

FEBS Press

The authors discovered that expression of the RNA-binding protein APOBEC3C (A3C) promotes clear cell renal cell carcinoma (ccRCC) growth by amplifying nuclear factor-kappa B (NF-κB) activity....

febs.onlinelibrary.wiley.com
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The final version of our latest study on how Rbfox1 controls focal adhesion gene splicing in cardiac muscle cells is now online. Thanks to all participating scientists! @jaime_csanchez @AlakhrasTala @StefanHttelmai1 @SinzAndrea #RTG2467 academic.oup.com/jmcb/advanc…

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

Abstract. Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein variants. However, it remain

academic.oup.com
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Marcel Köhn retweeted
Andrea Sinz@SinzAndrea
25 Jun 2023
I would like to thank all #RTG2467 students for your enthusiasm, your great work, and your fantastic support.👏👏 I could not be prouder to be part of this wonderful group at the end of a memorable week. @UniHalle @AcademicChatter #IDPs
RTG 2467 “Intrinsically Disordered Proteins”

ALT RTG 2467 “Intrinsically Disordered Proteins”

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Marcel Köhn retweeted
Andrea Sinz@SinzAndrea
21 Jun 2023
Thank you, our fantastic #RTG2467 coordinators, Claudia Spielmann and Janett Köppen, for a perfect organization of the RTG defense!🎉💐💐
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Marcel Köhn retweeted
Andrea Sinz@SinzAndrea
18 Jun 2023
…And another study originating from #RTG2467 on the functions of RAVER1 is now available as preprint! 🎉🎉Great work! 👏@StefanHttelmai1 @KoehnLab @unihalle biorxiv.org/content/10.1101/…

RAVER1 interconnects lethal EMT and miR/RISC activity by the control of alternative splicing

The RAVER1 protein was proposed to serve as a co-factor in guiding the PTBP-dependent control of alternative splicing (AS). Whether RAVER1 solely acts in concert with PTBPs and how it affects cancer...

biorxiv.org
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The RNA Society Meeting has concluded. Thanks to all our #RTG2467 students for presenting their latest results at the conference. We were happy to finally meet the RNA community again in person. See you next year in Edinburgh. @AlakhrasTala @jaime_csanchez
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Our newest PhD Student @AlakhrasTala presented her work on Cyclin L complexes in nuclear speckles at the RNA Society Meeting in Singapore. #RNA23 #RNA2023 #RTG2467 @UniHalle @unimedhal
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Luca M. Lauth (PhD Student) presented his poster on phase transition of SRSF1 (Ott & Köhn Labs collaboration) at the RNA Society Meeting Singapore. #RNA23 #RNA2023 #RTG2467 @UniHalle
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My PhD student @jaime_csanchez presented his poster about the role of the lncRNA FAM30A in acute myeloid leukemia during the RNA Society Meeting in Singapore. #RNA23 #RNA2023 #RTG2467 @unimedhal @UniHalle
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