#HBV #Tcells #tissueimmunity #antiviral #anticancer #immuneregulation #immunotherapy #preclinicalmodels #clinicaltranslation #imagingmassspec
Munich, Bavaria
Joined April 2022
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Institute of Molecular Immunology retweeted
A second priming phase promotes high-affinity CD8 T cells by coordinating CD4 help and the relay of IL-2 in subfollicular LN niches. Congrats to @Wue_SI’s Kasia, Deeksha, @Kamu_Lab @GeorgGasteiger . science.org/doi/10.1126/scie…
Job alert in our Institute of Molecular Immunology!
Two PhD positions in the field of immune regulation in autoimmune liver diseases. Both positions are embedded in the newly funded CRC1700 together with Hamburg.
Please check our official job announcement for more information
We are proud to host the GASL Annual Meeting 2025 from 14-15 February in Munich. The GASL program with fanatastic talks and poster is out now! Here you can find it👇
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We are proud to announce that the SFB 1700 Initiative "Immunregulation in der Leber: von Homöostase zur Krankheit" in which we will be part of will be funded for the next four years!🥳 Exciting opportunitiy to unravel immune-mediated mechanisms of autoimmune liver diseases!
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten:
➡️dfg.de/de/service/presse/pre…
We are excited that our study on the liver immune rheostat regulating CD8 T cell immunity in chronic HBV infection is published!🥳 @nature (nature.com/articles/s41586-0…)
🔎HBV-specific CD8 T cells are in close & prolonged contact with liver sinusoidal endothelial cells when recognizing their antigen on hepatocytes. We termed this close & prolonged contact an immune rheostat, that increases cAMP-PKA signalling and hampers T cell effector functions
Huge thanks to all of our collaborationpartners for their contributions and continuos help! @ProtzerLab @JBoettcherLab @maini_lab @LauerLab @LabOxenius
Huge thanks to all of our collaborationpartners for their contributions and continuos help! @ProtzerLab @JBoettcherLab @maini_lab @LauerLab @LabOxenius
Institute of Molecular Immunology retweeted
Now online! Therapeutic potential of co-signaling receptor modulation in hepatitis B dlvr.it/T8SXy2
Institute of Molecular Immunology retweeted
A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity @SciImmunology science.org/doi/10.1126/scii…
Institute of Molecular Immunology retweeted
NK cells undergo tissue redistribution during fasting, where the spleen and bone marrow microenvironments metabolically reprogram and prime NK cells to increase anti-tumor function @ScientistBecs @SunLab_Official @ImmunityCP cell.com/immunity/abstract/S…
Shape of naive T cells shapes the immune response. Pretty cool findings!
://www.science.org/doi/10.1126/science.adh8967
Institute of Molecular Immunology retweeted
Excited to share our latest publication in @SciImmunology! We've uncovered an NK cell-mediated immune checkpoint (B7H6 : NKp30) that limits CAR T cell persistence, revealing new insights into immune regulation. #Immunology @broadinstitute @DKFZ
science.org/doi/10.1126/scii…
This is a very impressive study just published in @Nature about the molecular and cellular mechanisms of liver regeneration after injury! There are migrating heptocytes😵 nature.com/articles/s41586-0…
Fantastic story from in-house research group @JBoettcherLab out today in @Nature! PGE2 impair the differentiation of stem-like CD8 T cells into effector CD8 T cells locally in the tumor. A very important study for the development of effective anti-cancer immunotherapy
We are thrilled that our study on PGE2-mediated impairment of TCF1+ stem-like CD8+ T cell responses in cancer, with (twitterless) Sebastian Lacher as first author, is now published @Nature! 👇 a short 🧵 below!
nature.com/articles/s41586-0…
Institute of Molecular Immunology retweeted
Please check out this exciting symposium @dkfz @DKFZImmunology coming up June 5 and 6! Fantastic international speakers on #immunology, #virology and #cancer!
Ask you students if they are interested– deadline for poster abstracts is April 30!
Extensive and diverse fitness program for T cells to uncover stengths and weaknesses of T cell effector functions cell.com/cancer-cell/fulltex…