@KlevitLab

@UWBiochemistry. Ubiquitin and small heat-shock proteins. Biochemistry and biophysics. Student-run account. Email Rachel with inquiries.

 Seattle, WA
klevitlab.org/
Joined August 2021
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  • Following108
  • Followers399
Please RT. Join the Kleviteers! Exciting post-doctoral opportunities available now. Uncover the mysteries of small heat shock proteins. Do a deep dive into protein ubiquitylation. Check us out at klevitlab.org/.
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Small Heat Shock Reunion! wix.to/a0be78S

Small Heat Shock Reunion!

A quick reunion of some current and past members of the small heat shock project. Whether it's from a new job, travels, or graduate school, we always enjoy coming back together for a walk and talk by...

klevitlab.org
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Klevit Lab retweeted
Zhao Lab@WXZhaoLab4 Oct 2023
Really happy to share our paper out today @ Molecular Cell, where we elucidate the pivotal roles of BRCA1-BARD1 ligase in not only early DNA end resection but also subsequent stages in homology-directed repair. Congratulations to all the authors! sciencedirect.com/science/ar…
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Grad School Updates: Natalie Stone pursues a PhD at University of Washington - #gradschool #research wix.to/RuDOs68
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Grad School Updates! #gradschool #research wix.to/ArJDgdW
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Grad School Updates! #gradschool #research wix.to/Zn6v5XP

Nicole Houppermans to Begin Grad School at University of Massachusetts Amherst

Undergraduate researcher Nicole Houppermans will begin graduate school at the University of Massachusetts Amherst in the Molecular & Cellular Biology Ph.D. program starting in August 2023. Congratu...

klevitlab.org
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The final version of our work highlighting the role of BARD1 in BRCA1/BARD1-mediated chromatin recognition and modification is out now @embojournal
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I'm a bit behind on posting this (as I just finished moving transatlantic) but my second PhD paper is finally published! @NatureComms nature.com/articles/s41467-0…
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The Preview ‘HHARI in motion reveals an unexpected substrate recognition site for RBR ligases’ from Ben Stieglitz @QMUL doi.org/10.1016/j.str.2022.0… highlights the recent Structure paper from @KlevitLab @UWBiochemistry: doi.org/10.1016/j.str.2022.0…
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Super excited for Chris Woods to defend his dissertation (working with @KlevitLab) gonna be 🔥🔥
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We are thrilled to share our work on Cullin-independent substrate recognition by the RBR E3 ligase HHARI, led by @KHReiter now out in @Structure_CP. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic. authors.elsevier.com/a/1fG9j…
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HDX-MS, XL-MS, and NMR studies reveal that HHARI is released from auto-inhibition by a phosphomimetic mutation, and that the Rcat domain contains a substrate-binding surface.
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A wonderful collaborative effort with the labs of Mike Guttman, Trisha Davis, and Mike MacCoss.
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There is a story that I have been wanting to tell for a while regarding a scientific journey that started more than 6 years ago. It’s been a really eye-opening process and I hope it can serve as an inspiration to others, especially those starting their research careers. A 🧵...
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Really excited (and a little jealous) that @tylergfranklin is spending the week up in the @KlevitLab at @UWBiochemistry. Can’t wait to see what kind of data he comes home with. I wonder if my old lab bench is available…
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I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.1101/…

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

The versatility of ubiquitination to impose control over vast domains of eukaryotic biology is due, in part, to diversification through differently-linked poly-ubiquitin chains. Deciphering the...

biorxiv.org
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Exciting new preprint from past lab member @HannahEBaughman
Hannah Baughman@HannahEBaughman13 Apr 2022
We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.
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1/4 Join us at this year's @FASEBorg summer conference "The Ubiquitin and Ub-like Proteins Conference: Cell Functions and Therapeutic Targeting" July 24-28 in Southbridge, MA. faseb.org/meetings-and-event…
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Check out our new review highlighting recent structural and cellular insights into BRCA1/BARD1 recognition and activity at nucleosomes!
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We're looking for a post-doc to join our BRCA1/BARD1 team. Lots of exciting science to be done. Contact Rachel @ [email protected].
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