Great to hear @MPSchuhMD taking about prematurity and nephron number as part of the @NIDDKgov Workshop on Congenital Kidney Disease

Join us for a virtual education symposium on neonatal nephrology on 20th October (12.30- 3.00pm Pacific/3.30-6.00pm Eastern). We will cover kidney development, acute kidney injury, neonatal dialysis, and neonatal conditions that affect kidney function. babykidney.org/sites/default…

On behalf of the NKC @NeonatalKidney, thank you all again so much for being here! Be on the look out for the next Neonatal Nephrology Journal Club, coming soon to a twitter feed near you! #KidNeo

What a fun and quick hour this was! Thank you all SO much for all your participation and support. So wonderful to learn from leaders like you! #KidNeo

In our last few minutes before the end of the hour, we'd like to hear how this study may change or impact your practice as a current or future 👶Neonatologist or 🫘Nephrologist. Leave a comment below! #KidNeo

It will be important that we continue to investigate the causes and risks of CKD in this growing population, as well as importance of close monitoring of premature kidney health through childhood and adolescence, and studies like this are helping us do just that! #KidNeo

As the authors discuss, more extremely preterm infants are surviving to adulthood, and as this population grows we are gaining more understanding of the long-term renal consequences of being born premature #KidNeo

T3⃣ Do you think the relatively good health of the study population played a role in the study findings? Perhaps those children who would have had more significant renal impairment as a result of prematurity were less likely to participate in a clinical trial? #KidNeo

T3⃣ The authors attribute the low rates of hypertension and lack of perturbations in biochemical markers of kidney-associated bone disease to the: ⭐️Small sample size, and ⭐️Overall health of the population included in the study #KidNeo

T3⃣ Of note, the study participants who were found to have reduced kidney function by mGFR and/or hypertension were referred for further evaluation #KidNeo

T3⃣ Should the authors have highlighted the eGFR findings more, since such a large proportion of the study population (✨over 80%✨) had reduced kidney function using this method of analysis? #KidNeo

T3⃣ They also note that eGFR was low in ✨13/16 study participants✨, but that few subjects had extra-renal manifestations of CKD including: ❤️Hypertension 🥩Proteinuria/microalbuminuria or 🦴Biochemical markers of abnormal bone metabolism #KidNeo

T3⃣ The authors report their major finding that children born before 28 weeks gestation have an increased incidence of renal impairment during adolescence, as evidenced by the statistically significantly lower👇 mGFR between the study population and the control group #KidNeo

Next up is Topic 3 (T3⃣) - Discussion

T2⃣ So taking things all together, only 25% of subjects had a low mGFR, but ✨over 80%✨ had a low eGFR! #KidNeo

T2⃣ Estimated GFR (eGFR) was calculated using measured serum creatinine and the Schwartz-Lyon equation adjusted for body surface area; eGFR was less than 90 mL/min/1.73m^2 for 13 subjects, and all four with mGFR less than 90 also had eGFR less than 90 #KidNeo