@KehatLab

Izhak Kehat's Molecular Cardiovascular System Research Lab @TechnionLive

 Haifa, Israel
kehatlab.net.technion.ac.il/
Joined July 2018
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  • Following461
  • Followers351
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Found in translation: Using single-molecule imaging, we show that ERK signaling controls where protein translation happens during hypertrophic stimulation in #cardiomyocytes —revealing a dynamic, localized response.
Circulation Research@CircResOct 4
Erlich & colleagues uncover a dynamic, location-based control of #protein synthesis in heart cells that drives #cardiac growth. Learn more at ahajrnls.org/3W5JJPG @itaie21 @KehatLab
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@CircRes Aug 28th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Cardiac MMA accumulation drives mitochondrial dyshomeostasis & damage under diabetes (arrow). Localized toxic onslaught (shield) is refractory to blood glucose control & traditional cobalamin supplementation.
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Kehat Lab retweeted
Hao Yin
@HaoYin20Jul 23
Induced Lox KO in Myh11+ Smooth Muscle Cell, but not PDGFRα+ fibroblast, ⏬Angiotensin II-induced 🐭Cardiac Fibrosis Cardiac hypertrophy remains unaltered in both Lox KO models A possible SMC-to-Fibroblast matrix/mechano-transducive cascade in fibrosis bioRxiv 2026 biorxiv.org/content/10.64898…
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Oren Caspi
@MDCaspiJul 13
בקשה מיוחדת...אנא שתפו והפיצו כדי שיגיע לכמה שיותר מטופלים. אי ספיקת לב מתפתחת ב-1 מתוך כל 4 אנשים במהלך חייהם. ב-15/7/2026 יום רביעי ב-11:00 מקיימים את כנס המטופלים הראשון באי ספיקת הלב ברמב"ם ובשיתוף עם החוג לאי ספיקת הלב באיגוד הקרדיולוגי. הירשמו עכשיו והצטרפו ... rambam-patient-hub.lovable.a… הכנס לרגל פתיחת מרכז חדש ברמב"ם למניעה וטיפול באי ספיקת הלב בכל שלבי המחלה. שיקום ופעילות גופנית מונעת, מרפאות, טיפול אמבולטורי מתקדם, טיפול וניטור דיגטלי, מבחני מאמץ לב-ריאה, צינתורים המודינמיים, מרכז טכנולוגיות מתקדמות, טיפול בתמיכה מכנית זמנית וקבועה (LVAD) ובקרוב גם טיפול נמרץ לאי ספיקת הלב.
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Join us in Minneapolis for the 2026 ISHR North American Section Meeting! 📍 Minneapolis, MN 📅 May 31–June 3, 2026 Promoting the next generation of basic and translational scientists. Reserve your spot today! #ISHRNAS2026 ishrnorthamerican.org/meetin…
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Ghiringhelli et al bioengineered a human-like #atrial heart model that reproduces complex #arrhythmias & can be precisely controlled with light (#optogenetics). Learn about this new platform for studying #AFib at ahajrnls.org/4tVnVCr
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What Mr. Trump’s career in business and politics has made clear is he understands one concept better than any other: leverage. open.substack.com/pub/thomas…
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view.ecommunications2.umn.ed…
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Huge congrats to Dr. Jop van Berlo (@UMNews) and Dr. Silvia Guatimosim (UFMG) on receiving the @American_Heart International Visiting Professor Award. They’re combining forces to tackle the complexities of cardiac remodeling and molecular cardiology. #Cardionerds #UMNresearch
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Replying to @Ramihdd
@Ramihdd & colleagues by charting the heart cell #proteome & using #CRISPR for precise validation, identified a key protein that sustains the heart #proteostasis & preserves #mitochondrial protein levels. Find out more at ahajrnls.org/3NFIQJG @KehatLab
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New #SkeletalMuscle paper: FibroTrack: a standalone deep learning platform for automated fibrosis quantification in muscle and cardiac histology. tinyurl.com/4vt9f6z4
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Finally out: We used CRISPRa/i to show that virtually ANY genomic site can become regulatory for cardiac genes—even without accessibility or active marks. TF recruitment remodeled chromatin & changed expression up to 70 kb away. doi: 10.1016/j.isci.2025.114040
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pubmed.ncbi.nlm.nih.gov/4153…

Recruitment of transcriptional effectors by Cas9 creates cis-regulatory elements and demonstrates...

Regulation of cardiac gene expression, especially for sarcomeric genes, is crucial for heart function and is often mediated by distal regulatory elements such as enhancers and repressors. Despite...

pubmed.ncbi.nlm.nih.gov
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Tucker is indeed a scavenger, and the carcass he ransacks is the once great tradition of conservative thought in this country. thomasvondriska.substack.com…
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1/ Can #Axolotls teach us new things about #HeartRegeneration? A great collaboration between @Tanaxolotl and Miguel Torres lab. We’re happy to share our new work in which we ask how axolotls regenerate their hearts and could they help mammals with that? doi.org/10.64898/2025.12.21.…
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Excited to launch the Landau-Levi Lab at @TechnionLive ! We develop organ-on-a-chip systems focused on cardiac and multi-organ interactions and the role of immune cells in shaping tissue function. Learn more: thelandaulab.com

Shira Landau Levi

Welcome to the Shira Landau-Levi Laboratory. We develop advanced human organ-on-a-chip systems to study the heart, immune-vascular interactions, and multi-organ communication. Our goal is to create...

thelandaulab.com
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We look forward to welcoming you in #Birmingham @VisitBritain @ISHR_ES @unibirmingham
ISHR European Section@ISHR_ES11 Dec 2025
Abstract submission and registration now open!! uobevents.eventsair.com/39th… Travel awards for PhD students are available - see the website for information #CardioResearch #ECR @ISHR_ECI @IshrMci @ISHR_NAS @JMCCardiology @jmcc @BSCResearch
International Society of Heart Research conference 2026

ALT International Society of Heart Research conference 2026

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Quantifying cardiomyocyte contraction & nuclear deformation interaction reveals nucleus-damaging mechanism underlying LMNA cardiomyopathy 📷 @AmiadDaria & @julieheffler et al @WeillCornell @PennMedicine in @NatureCVR ➡️ bpod.org.uk/archive/2025/10/…
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