@KateCarrollLab

#chemicalbiology @UFScripps

 Jupiter, FL
katecarroll.com
Joined April 2019
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  • Following301
  • Followers843
4Media
New frontiers in sulfur and selenium chemical biology sciencedirect.com/science/ar… Check out this 20 article issue. Many thanks to all contributors!
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2024 Priestley Medal to Bertozzi cen.acs.org/people/awards/Ca… via @cenmag Congrats!
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Also see this insightful News and Views by Daniel Bak nature.com/articles/s41589-0…

Flipping the polarity switch

Nature Chemical Biology - A new platform for screening nucleophilic-fragment-based covalent ligands enables the identification and targeting of ligandable sulfenic acid sites, setting the stage for...

nature.com
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We are very excited to share our new study @nchembio with @Yang_J_lab on ‘nucleophilic covalent ligand discovery for the cysteine redoxome’ rdcu.be/ddgng #UFScripps #chemicalbiology #cysteine
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AddThis | Home authors.elsevier.com/c/1gyRb…
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I had a feeling it would be this year - @CarolynBertozzi warmest congratulations on winning the #Nobleprize2022 - you are a STAR! #chemicalbiology
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Read our latest #research on ‘turn-on’ fluorescence sensing of #cysteine oxidation published in @NatureComms rdcu.be/cV0bq @UFScripps #chemicalbiology #redoxbiology
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Chaperone-Directed Ribosome Repair after Oxidative Damage biorxiv.org/content/10.1101/… #chemicalbiology #redoxbiology

Chaperone-Directed Ribosome Repair after Oxidative Damage

Reactive oxygen species are ubiquitous in cells, where they damage RNA and protein. While relief mechanisms, including effects on translation, have been described, whether ribosomes are functionally...

biorxiv.org
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Defining and refining the cysteine redoxome with sulfur chemical biology | ChemRxiv doi.org/10.26434/chemrxiv-20…

Defining and refining the cysteine redoxome with sulfur chemical biology | ChemRxiv

Posttranslational changes in the redox state of cysteine residues can rapidly and reversibly alter protein function, modulating biological processes and drug pharmacology. Recent innovations in...

chemrxiv.org
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Nucleophilic covalent ligand discovery for the cysteine redoxome | ChemRxiv doi.org/10.26434/chemrxiv-20…
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chemrxiv.org/engage/chemrxiv…

Nucleophilic covalent ligand discovery for the cysteine redoxome | ChemRxiv

The convergence of reactive cysteine-targeted electrophilic fragments and chemoproteomics have dramatically accelerated the discovery of ligandable sites in the proteome. Our genome encodes 214,000...

chemrxiv.org
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explore.jobs.ufl.edu/en-us/j…
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The @katecarroll_lab is hiring postdocs with a strong record of publication in the areas of #syntheticchemistry and #chemicalbiology. Applicants should apply with their CV and a cover letter briefly summarizing their research to [email protected]
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Read this #preprint on @researchsquare: Reaction-based fluorogenic probes for selective detection of cysteinyl oxidation in living cells researchsquare.com/article/r…
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Old chemistry, new tricks @NatureChemistry ! Repurposing Wittig reagents for redox biology. See our collaborative work with @Jing18517377 rdcu.be/cxTRU #wittig #bioorthogonal #chemicalbiology
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Parallel evaluation of nucleophilic and electrophilic chemical probes ... sciencedirect.com/science/ar…
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Parallel evaluation of nucleophilic and electrophilic #chemicalprobes for #sulfenicacid: Reactivity, Selectivity and Biocompatibility @scrippsflorida biorxiv.org/cgi/content/shor… #bioRxiv #redoxbiology
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Thiol-based #chemicalprobes developed @UNC @scrippsflorida @Udelaruy exhibit antiviral activity against SARS-CoV-2 through allosteric #disulfide disruption in the spike glycoprotein biorxiv.org/cgi/content/shor… #bioRxiv #COVID #redoxbiology
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Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting researchsquare.com/article/r…
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Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting researchsquare.com/article/r…

Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry...

Triphenylphosphonium ylides, known as Wittig reagents, are one of the most commonly used tools in synthetic chemistry. Despite their considerable versatility, Wittig reagents have not yet been...

researchsquare.com
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