@Karras_Lab
mdanderson.org/research/departments-labs-institutes/labs/karras-laboratory.html
Joined June 2015
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Excited to share our latest story @MolecularCell @MDAndersonNews the discovery of HSP90-buffered mutations in BRCA1, led by postdoctoral trainee Dr. Brant Gracia and PhD student Xing-Han Zhang cell.com/molecular-cell/full…

HSP90 buffers deleterious genetic variations in BRCA1

Gracia et al. show that HSP90 buffers BRCA1 mutations by stabilizing the encoded mutant proteins, promoting PARP inhibitor resistance. Low-level HSP90 inhibition selectively hypersensitizes HSP90-b...

cell.com
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Excited to share that I’ve been promoted to Associate Professor with tenure! Deep thanks to my amazing team, mentors, collaborators, and colleagues! Looking forward to the next chapter of discoveries and growth opportunities!
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Delighted to share that our proposal to study Hsp90's role in therapy resistance in head and neck cancer is now awarded! Thank you to CPRIT for supporting this work.
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Delighted to share our new preprint. HSP90 buffers mutations in BRCA1, thus influencing cancer predisposition. biorxiv.org/content/10.1101/…

HSP90 buffers deleterious genetic variations in BRCA1

Protein-folding chaperone HSP90 buffers genetic variation in diverse organisms, but the clinical significance of HSP90 buffering in disease remains unclear. Here, we show that HSP90 buffers mutations...

biorxiv.org
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Delighted to share our new story is out in Science. Find out how industrial yeasts got their duplicated genes, here @ScienceMagazine : science.org/doi/10.1126/scie…

Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the...

science.org
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Delighted to share our new story "Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers" in Cell Reports. Read our publication here: cell.com/cell-reports/fullte…

Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1...

Gracia et al. show that the binding pattern of protein-folding chaperones to BRCA1 variant proteins predicts structure-function relationships and clinical outcomes. They find that the degree of HSP70...

cell.com
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We are excited to share a preprint of our work: Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk in BRCA1 Mutation Carriers biorxiv.org/content/10.1101/…

Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk in BRCA1...

Identifying pathogenic mutations and predicting their impact on protein structure, function and phenotype remain major challenges in genome sciences. Protein-folding chaperones participate in...

biorxiv.org
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we are excited to share a preprint of our work Ethanol Drives Evolution of Hsp90-Dependent Robustness by Redundancy in Yeast Domestication! biorxiv.org/content/10.1101/…

Ethanol Drives Evolution of Hsp90-Dependent Robustness by Redundancy in Yeast Domestication

Protein folding promotes and constrains adaptive evolution. We uncover this surprising duality in the role the protein-folding chaperone Hsp90 plays in mediating the interplay between proteome and...

biorxiv.org
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Postdoctoral trainees are major drivers of research and innovation. It's been a pleasure to work with Upasna Thapar and Nick Economos, in a great collaboration with Peter Glazer. Please read our publication here: doi.org/10.1016/j.jbc.2022.1… #PostdocAppreciationWeek @Karras_Lab
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Our work on mechanisms of DNA triplex-mediated gene editing is published! PMID: 35988651 sciencedirect.com/science/ar…
Georgios received the Kleberg Innovator Award from The Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation. We thank you for your support!
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Congratulations to Brant Gracia for being awarded the Kirschstein National Research Service Award (NRSA) F32 Individual Postdoctoral Fellowship for his postdoctoral work!
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Engineering human cell lines is now as easy as engineering yeast! nature.com/articles/s41467-0…
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SMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover biorxiv.org/content/10.1101/…

SMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover

Structural maintenance of chromosomes (SMC) complexes, cohesin, condensin and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromos...

biorxiv.org
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SMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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Racism is everyone’s problem genestogenomes.org/racism-is… via @GeneticsGSA

Racism is everyone’s problem

As yet another Black man suffocates under a policeman’s knee, cities burn, and the coronavirus spreads a disproportionate burden of suffering and death to communities of color, we are in a moment...

genestogenomes.org
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Congratulations to Anna Tanaka on her admission to Medical School at Case Western Reserve University School of Medicine!
Congratulations to Youssef Sabha on his admission to Graduate School at Rutgers University!
Congratulations to Hatim Amiji on receiving the Frederick B. Rudolph Award for Outstanding Senior student from RICE University!
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Congratulations to Dipak Patel on his admission to Graduate School at Baylor College of Medicine!
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