Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex disq.us/t/3xpe908 - development of a circuit-neuroscience based rational drug target discovery approach, using impulse control disorders as example - congrats Bas!
Our second paper on circuit mechanisms in anterior cingulate cortex (ACC) controlling impulsivity and attention got published and points to an enhancement of Gq-signalling in ACC parvalbumin interneurons as therapeutic concept in ADHD - congrats Martin! nature.com/articles/s41398-0…
Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents hardware-x.com/article/S2468…
Likewise, we are extremely happy to announce that the pure electrophysiology version of Open-MAC with up to 256 recording cannels can now be purchased fully assembled from Cambridge NeuroTech - thanks to Thal & Henry for their great efforts! cambridgeneurotech.com/commu…
We are really grateful that @LabMakerOSH & @CambNeuroTech are helping to make open-source tools like Open-MAC widely available to the Neuscience community, making implementation in the lab as easy as possible. Updates on the electrophysiology+optogenetics version to follow.
@ this occasion, despite much delay, we also want to give @SampathKumarTK 's 1st development its deserved Twitter-appearance: A low-cost open-source 5-choice operant box system optimized for electrophysiology and optophysiology in mice disq.us/t/42vvvgc -
A poke-hole based operant box-system optimized for miniscope or electrophysiological recordings, or optogenetics during behaviour. It's based on @pyControl software & hardware developed by Thomas Akam and described separately in doi.org/10.7554/eLife.67846
Design files fitting for 4 of the 5 Open-MAC versions (miniscope-only, ephys-only 32/64 rec-channels, miniscope+ephys) are available on @github under github.com/KaetzelLab/Open-M… . Design-files for the optgenetics+ephys version and info on commercial availability will follow soon.
Delayed-matching-to-position working memory in mice relies on NMDA-receptors in prefrontal pyramidal cells disq.us/t/3wd8fcw - Working memory (diversity) day continued: prefrontal NMDA receptors are necessary for DMTP but not T-maze alternation WM - congrats Kasyoka!
Highly task-specific and distributed neural connectivity in working memory revealed by single-trial decoding in… disq.us/t/3wczaer Our machine-learning analysis of neural connectivity underlying working memory, battling the streetlight effect - congrats Daniel & Sampath!
bioRxiv viewer disq.us/t/3v3b8tw The power-house of all our operant box experiments, pyControl, now finally described and publicized in full! A fantastic tool! Thanks Thomas!
Our new review scrutinizing the evidence for a causal role of general and cell-type-specific hypofunction of NMDA-receptors in schizophrenia: doi.org/10.3389/fpsyt.2019.0…
Thanks to the reviewers Margarita Behrens (Salk) and Vasileios Kafetzopoulos (Harvard) for their great comments!