@Kachroo_Lab

Temporarily closed @SynBioCU with PI @Aashiq_Kachroo. Our lab engineers human biological process in yeast to study disease & evolution.

 Montréal, Québec
Joined April 2017
  • Tweets617
  • Following344
  • Followers431
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Congratulations to @shormin_sultana for tremendous effort in finding these suppressors and to @MudabirAbdullah for finishing where Sarmin left off. Congratulations to our collaborators from Yale, Mark Hochstrasser and Jianhui Li, for characterizing the variants.
Aashiq Kachroo@Aashiq_Kachroo22 Jun 2022
This work from @Kachroo_Lab focused on functionally non-replaceable human genes. By developing an automated, high throughput pipeline, we obtained human gene variants of human Beta2 subunit of the proteasome core that can cover for the corresponding a yeast gene function.
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Packy McCormick
@packyMJan 17
Spend an hour reading this weekend and I think you’ll know more about robotics than 99% of people, including some people who invest in robotics. notboring.co/p/robot-steps

Many Small Steps for Robots, One Giant Leap for Mankind

A Co-Written Essay with Evan Beard

notboring.co
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Tom Ellis@ProfTomEllis11 Jul 2025
Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. cell.com/cell/fulltext/S0092…

Engineering yeast multicellular behaviors via synthetic adhesion and contact signaling

By designing synthetic toolkits for contact-based signaling (MARS) and cell-cell adhesion (SATURN), we program yeast to form multicellular structures and perform complex tasks, like building logic...

cell.com
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Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/S0092…

Pervasive mislocalization of pathogenic coding variants underlying human disorders

Pathogenic missense variation can affect protein function in many ways, but the role of protein mislocalization has not been systematically assessed. By characterizing the localization of 3,400...

cell.com
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High-res In-situ Structures of Mammalian Respiratory Supercomplexes in Reaction within Native Mitochondria biorxiv.org/content/10.1101/… Check out my lab's first work on membrane proteins! Yes, we knew nothing about detergent😜, so we directly imaged proteins within native membrane!
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elevyLab@ElevyLab19 Mar 2024
Embarking on a new life's chapter as I join @MoCel_Geneva and @sciences_UNIGE. Feeling both excited and sad leaving my Weizmann family. Here's to new scientific adventures about proteins, assemblies, proteomes, and yeast!
Biologie - UNIGE@Biologie_UNIGE19 Mar 2024
🤗 We are delighted to welcome Emmanuel Levy @ElevyLab and his team in the @MoCel_Geneva Department. We wish them all the best with us in Geneva! ✨ @sciences_UNIGE @unige_en
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elevyLab@ElevyLab8 Feb 2024
From asymmetry to symmetry, beautiful complex structure
This Post is from an account that no longer exists. Learn more
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We are thrilled to present a new #enzyme to the world, the first shown to break the man-made carbon-silicon bonds in #siloxanes, which are persistent in the environment. caltech.edu/about/news/teach…

Teaching Nature to Break Man-made Chemical Bonds

Newly evolved enzyme could one day make silicone compounds biodegradable

caltech.edu
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Kachroo Lab retweeted
Dan Tyrrell@danis133719 Jan 2024
Excited to finally share this final product! Analysis of NIH K99/R00 awards and the career progression of awardees elifesciences.org/articles/8… There is bias in faculty hiring networks! bottom line.

Analysis of NIH K99/R00 awards and the career progression of awardees

There is a significant disadvantage to receive a major grant (i.e., R01) for K99/R00 awardees that are women, those at lower funded institutions, and those with lower career mobility.

elifesciences.org
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Please RT. Interested in understanding the role of chromosome instability and micronuclei in cancer development? We have a postdoc position @IEOufficiale generously funded by @WorldwideCancer to work on this exciting topic. Starting date April 1, 2024.
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Do have an interest in #GPCR signaling? Did you always want a good assay that worked in your favorite cell type? Even with endogenous GPCRs? This might be for you. We got some surprises about endogenous GPCR behavior. Remi + Marcin led, with help from many biorxiv.org/content/10.1101/…

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

G protein-coupled receptors (GPCRs) are the largest family of druggable proteins in the human genome, but progress in understanding and targeting them is hindered by the lack of tools to reliably...

biorxiv.org
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Decoding human genetic variation using a synthetic paradigm go.nature.com/3uNVT28 #JournalClub by @Aashiq_Kachroo
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"Check out my journal club blurb in @NatureRevGenet on #humanizedyeast, deep mutational scanning, featuring the recent article from @FPRoth's group predicting the impact of missense variants in human HMBS on Porphyria. rdcu.be/dsUR4"
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I’ve handled the review of > 1000 papers at @nature. Over time, you notice aspects of presentation on which reviewers tend to comment. In the interests of minimizing hassles during review, I offer the following suggestions (a bit targeted to climate papers).
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Shih_Lab@shihlab11 Nov 2023
Hey @Pointe_Claire resident or any resident of @Montreal. Do you want to know how #covid tests are made? My lab is at #exposcience in Pointe-Claire showing off how such devices are made. Happening this weekend! pointe-claire.ca/en/calendar… #outreach #biotech #microfluidics #synbio
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BryanRoth
@zenbrainest20 Oct 2023
BREAKING NEWS: SCHIZOPHRENIA IS A DISEASE OF THE SYNAPSE!! nature.com/articles/s41380-0…
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Logging back on long enough to say that this is embarrassing.
nature
@Nature9 Oct 2023
How purposeless physics underlies purposeful life go.nature.com/48MBIkM
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Just found out my friend got murdered in his house together with his wife and all his kids. He was a very good man who helped anybody as a principle, even if you weren't close with whatever you might need. A real Kibbutznik. I am broken. Everybody around me getting similar news.
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“even yeast cell biologist” sums it all.
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Thrilled to share our work profiling Ale yeast protein dynamics across fermentation and serial repitching! biorxiv.org/content/10.1101/… @DunhamLab @edward_marcotte @LiveOakBrewing #BeerYeast #SystemsBiology #Proteomics Sneek Peak thread🧵 below

Systematic Profiling of Ale Yeast Protein Dynamics across Fermentation and Repitching

Studying the genetic and molecular characteristics of brewing yeast strains is crucial for understanding their domestication history and adaptations accumulated over time in fermentation environmen...

biorxiv.org
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🎉 @Kachroo_Lab Exciting News! 🇨🇦 renewal of Canada Research Chair funding for another five years! 🌟 A big shout-out of gratitude to the referees, reviewers, and, most importantly, our brilliant trainees! 🙌👏 #ResearchRenewal #Innovation #Thankful concordia.ca/news/stories/20…

Government of Canada invests more than $7M in Concordia research | News - Concordia University

Scholars will build on their investigations through Canada Research Chairs and the Canada Foundation for Innovation.

concordia.ca
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