kons retweeted
Excited to share a Perspective we wrote on ecDNA‘s spatial and genomic mobility and it’s implications for cancer therapy, out today @NatureGenet
Thank you to @SafiaDanovi for the great editorial process !
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nature.com/articles/s41588-0…
kons retweeted
Today is ecDNA hubs day !! Very happy to share this work by the @HowardYChang team led by @kinglhung @KatieEYost and with some contributions of our team @KHelmsauer and @StefanMundlos out today @Nature 🔥🔥🔥 nature.com/articles/s41586-0…
Congratulations @kinglhung, @KatieEYost, @549nm @HowardYChang!! Fascinating ideas, impressive experimentation, intriguing results!
Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s41586-0…
Congrats Heathcliff, Anton and all involved, great paper 👏👏👏
🔥🔥New preprint from our lab:
We identified a new clinically exploitable synthetic lethal ATR dependency in rhabdomyosarcoma, a devastating cancer affecting children and young adults. 💊💊🦀🦀
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cutt.ly/bhQY3Ff
So exciting to this see this out! I really enjoyed working on this together with @RichardKoche @anton_gh Maria Valieva, @sali_tub, @StefanMundlos and everyone else involved! Thank you so much everyone!
🔥Very excited to share our new paper!
By integrating long-read DNA sequencing with 3D chromatin mapping,
@KHelmsauer , @RichardKoche and the @MundlosLab defined key epigenetic properties of extrachromosomal circular oncogene amplification ! #ecDNA
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nature.com/articles/s41467-0…
