Dr. Jacobson is Chief of the Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Bethesda, MD
Joined May 2009
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Kenneth Jacobson retweeted
Great new research on A3R agonism in brain homeostasis, reinforcing its role as a brain stress sensor that translates extracellular adenosine changes into adaptive glial responses, with implications for protecting the brain during stress and injury! science.org/doi/10.1126/scia…
Kenneth Jacobson retweeted
Very exciting to have this new review out today by Ted Liston, who pioneered AST-004's development over this past decade! It has indeed been a remarkable journey! Thanks to Jim Lechleiter, @KAJacobson, and everyone across the @AstrocytePharma team! link.springer.com/article/10…
Kenneth Jacobson retweeted
Thanks to @BioTuesdays for the deep dive on our work at @AstrocytePharma. 2026 is a pivotal year: Phase 2 trials are enrolling, our Series B is underway, and we’re moving closer to that much-needed neuroprotective therapy for #TBI and #stroke patients! biotuesdays.com/2026/02/03/a…
Kenneth Jacobson retweeted
UDP-glucose and MRS2905 agonist-bound states of the purinergic P2Y14 receptor: Communications Biology, Published online: 21 November 2025; doi:10.1038/s42003-025-09174-6The authors cracked P2Y14’s “sweet tooth”: structures bound to UDP-glucose and… nature.com/articles/s42003-0…
Kenneth Jacobson retweeted
Footy star reveals concussion toll: 'I haven't slept unaided in years' mol.im/a/14752339 via @MailSport Astrocyte's new #STARFAST clinical trial is now treating concussed players in the Adelaide Footy League with AST-004 to see if we can limit these debilitating effects.
Kenneth Jacobson retweeted
Great story by 7NEWS Adelaide covering @AstrocytePharma STARFAST Phase 2 clinical trial!! facebook.com/share/v/16Y4ory…
Kenneth Jacobson retweeted
🚀 More great news! @AstrocytePharma is honored to receive a $3M grant from the NIH to further advance the oral formulation of AST-004 toward an IND and the clinic! #concussion #TBI astrocytepharma.com/2025/06/…
Carolyn Bertozzi delivered an amazing Margaret Pittman lecture today at NIH, & succeeded to explain complicated bioorthogonal chemistry to the broader scientific audience.
Kenneth Jacobson retweeted
Astrocytes are stepping into the spotlight. 🌟
A trio of new Science papers reveals just how central these cells are to brain function—and why they may be the key to recovery after injury. Huge implications for TBI and stroke.
science.org/doi/10.1126/scie…
Kenneth Jacobson retweeted
Astrocytes have long been conceived as passive support player cells in the brain. But today @ScienceMagazine (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function
science.org/doi/10.1126/scie…
Kenneth Jacobson retweeted
A great week at the #TBIconference—Astrocyte was thrilled to be part of the scientific exchange and momentum driving new treatments forward. Dr. Korinek presented updates on the cerebroprotectant AST-004 advancing to Phase 2 clinical trials. #concussion #TBI #BrainHealth
Kenneth Jacobson retweeted
Summary of Astrocyte's Phase 1A clinical trial of AST-004 featured this month in @StrokeAHA_ASA's Article Commentary. For the Phase 1B study that also showed high safety and tolerability of extending dosing, the manuscript is in preparation - stay tuned! ahajournals.org/do/10.1161/b…
irp.nih.gov/blog/post/2025/0…
Photoswitchable A3 adenosine receptor agonist @IRPatNIH
Kenneth Jacobson retweeted
Beautiful excursion into the history and importance of Photoremovable Protecting Groups: pubs.acs.org/doi/10.1021/jac… One of the best papers I have read this year. Congratulations to authors!
Cryo-EM A3 adenosine receptor structures, from SIMM, with both of the potent and selective A3 agonists that are in advanced clinical trials by CanFite. We invented both molecules, and they are widely used in research, as well: IB-MECA and Cl-IB-MECA. doi.org/10.1038/s41467-024-4…
Kenneth Jacobson retweeted
Meet with @AstrocytePharma at #ASCPT2024! Astrocyte’s Lisa Manna will be presenting our poster with @QPSHoldingsLLC on the Phase 1B trial of AST-004, and its innovative use of serial CSF collection!
Kenneth Jacobson retweeted
🔊🔊 New manuscript alert! For a side project during my PhD we explored novel 7-deaza ribonucleosides with dual N6/C7 substitutions and serendipiously discovered nucleosides with a cool tricyclic base. Check it out now in ACS Med Chem Letters: pubs.acs.org/doi/10.1021/acs…
Kenneth Jacobson retweeted
The final version of this study has appeared today in @NatureChemistry : nature.com/articles/s41557-0…
Today in @ChemRxiv (bit.ly/3ic6OMI): Democratized access to stereo pure thioisosteres of life's building blocks with promising translational potential in medicine. New reagents and a completely different strategy coupled to some amazing collaborators enabled this study.
Kenneth Jacobson retweeted
Looking forward to presenting the John Daly Lecture tomorrow @NIH
"Natural Products Reveal Receptors for Perceptions"
Zoom link below:
videocast.nih.gov/watch=5108…
Kenneth Jacobson retweeted
Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells pubmed.ncbi.nlm.nih.gov/3760…
