@JustinM_Roberts
 Boston
Joined March 2018
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  • Followers16
Solid work out from @AniaPuszynska! Happy to be a part of it!
Ania Puszynska
@AniaPuszynskaJul 30
Excited to see our work now published science.org/doi/10.1126/scie…! Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo...

science.org
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Justin Roberts retweeted
Ania Puszynska
@AniaPuszynskaJul 30
Excited to see our work now published science.org/doi/10.1126/scie…! Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo...

science.org
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Justin Roberts retweeted
Kendall@kendyjco23 Oct 2020
So great to put this out! Many years in the making. We used #CRISPR screens to find #mTORC1 regulators and clarified how #mitochondria "talk" to mTORC1. biorxiv.org/content/10.1101/…

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial...

In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. Because the full complement of these proteins has not been...

biorxiv.org
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Our lab's donation for local Cambridge hospitals via the Cambridge Local Emergency Planning Committee. Please other labs give what you can. Thank you for organizing to our awesome lab manager Edie!
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Congratulations Grace on this review! Huge effort on your part and so great to see it online!
Whitehead Institute@WhiteheadInst14 Jan 2020
“Perched at the interface between organisms and their environments” — Grace Liu and Institute Member @DMSabatini review mTOR’s role at the nexus of nutrition, growth, aging and disease: ow.ly/rprj50xV3zN @NatRevMCB @MITBiology @ScienceMIT @HHMINEWS
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Congrats Kendall!
David M. Sabatini@DMSabatini15 Nov 2019
Congratulations @kendyjco on your new review and poster. When I travel I am often asked if we will update the previous mTOR signaling poster from @LaplanteMathieu. Here it is! Nutrient regulation of mTORC1 at a glance jcs.biologists.org/content/1…
Congratulations @kendyjco on your new review and poster. When I travel I am often asked if we will update the previous mTOR signaling poster from @LaplanteMathieu. Here it is! Nutrient regulation of mTORC1 at a glance jcs.biologists.org/content/1…
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Justin Roberts retweeted
Jordan Ray@thejordanray21 Sep 2019
Annual Sabatini lab mountain bike ride at the Whitehead Retreat.
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Justin Roberts retweeted
Jordan Ray@thejordanray22 Sep 2018
Annual whitehead retreat mountain bike ride
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New May issue, out now! Check it out: go.nature.com/2vm58rg
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