@JunLuLab

Jun is a member of Yale Stem Cell Center

Joined April 2019
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Is it possible to design virus-specific anti-viral therapeutics to prepare for the next viral outbreak? Check out our new manuscript! In Silico Design of siRNAs Targeting Existing and Future Respiratory Viruses with VirusSi biorxiv.org/content/10.1101/…

In Silico Design of siRNAs Targeting Existing and Future Respiratory Viruses with VirusSi

The COVID-19 pandemic has exposed global inadequacies in therapeutic options against both the COVID-19-causing SARS-CoV-2 virus and other newly emerged respiratory viruses. In this study, we present...

biorxiv.org
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A great webnar. Looking forward to
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Post-transcriptional Regulation is the Major Driver of microRNA Expression Variation. Post-Transcriptional regulation rules! #microRNA #miRNA #cancer biorxiv.org/content/10.1101/…

Post-transcriptional Regulation is the Major Driver of microRNA Expression Variation

MicroRNA (miRNA) expression patterns are highly variable across human tissues and across cancer specimens. The intuitive assumption is that transcription is the main contributor to mature miRNA...

biorxiv.org
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Our manuscript on bioRxiv: microRNA seedless sites attenuate strong-seed-site-mediated target repression biorxiv.org/content/10.1101/…

microRNA seedless sites attenuate strong-seed-site-mediated target repression

MicroRNAs (miRNAs) regulate protein-coding gene expression primarily through cognitive binding sites in the 3’ untranslated regions (3′ UTRs). Seed sites are sequences in messenger RNAs (mRNAs) that...

biorxiv.org
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Welcome Carl Walkley to our stem cell center! Great to see a friend from the opposite side of the globe.
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Wonder what happens to the codons of those mt genes, which is different in mt from nuclear genome
Science News
@ScienceNews26 Apr 2019
One parasite’s energy factories have gone nuclear. The organism’s mitochondria have transferred all of their DNA to the hosts’ nucleus. ow.ly/HkfF30owKIj

This marine parasite’s mitochondria churn out energy without DNA

Missing mitochondrial DNA inside a parasitic marine microbe turned up inside the organism’s nucleus.

sciencenews.org
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A research team reports in Nature that several recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, extending beyond the targeted DNA. go.nature.com/2Islggz
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