Cell biologist interested in melanoma research. Group Leader @ Instituto de Investigaciones Biomedicas Alberto Sols CSIC-UAM @IIBmCSICUAM. @jlorgaz.bsky.social
Joined December 2019
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Interested in the cytoskeleton and therapy resistance, in particular in melanoma? Have a look at our review just published
mdpi.com/2073-4409/11/3/518
@IIBmCSICUAM
Thanks so much @CicMechano for the invitation!
Jose Orgaz retweeted
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM
@ASCO
ALT Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
Jose Orgaz retweeted
Delighted to share our latest piece on our favourite cancer cells! Well done @RitobrataGhose 👏
Amoeboid cancer cells at a glance journals.biologists.com/jcs/…
Jose Orgaz retweeted
🗣️ Numerosos miembros del #IIBmCSICUAM están en Zaragoza en el #ASEICACongress de @ASEICAnews 👏
🔶Organizadores @GemaMorBue @JuanCarlosLpz13
🔶#ASEICAJoven Emilio @Erios_12 del grupo @imaigenelab
🔶También María Alieva
@AndreaGarciaPrz @JoseOrgaz2,
@Dolmeda
@GdC_CCCB_lab
Jose Orgaz retweeted
Representing the Cytoskeleton and Metastasis Lab @IIBmCSICUAM at the 19th International #ASEICACongress with our great group leader @JoseOrgaz2 & my amazing lab mate Marta Durán. We’re really enjoying being able to share results & learning from great scientists @ASEICAnews
Jose Orgaz retweeted
Excited to co-organize the virtual @EACRnews @Boehringer Conference: Drugging & Regulating the MAP Kinase Pathway! Submit an abstract or join us. Please RT and share with others.
Details & registration:
eacr.org/conference/boehring…
Delighted to comment on a beautiful paper by @MegDrisc @DanuserLab
Creating a path during melanoma amoeboid migration: When too crowded, start worrying sciencedirect.com/science/ar…
@IIBmCSICUAM
Paper @Dev_Cell @MegDrisc @DanuserLab
Proteolysis-free amoeboid migration of melanoma cells through crowded environments via bleb-driven worrying
sciencedirect.com/science/ar…
This paper is so cool! Congratulations @jess_ljx @arjunrajlab and team!!
Excited to share our new
@biorxivpreprint in which we demonstrate the formation and maintenance of cellular memories in melanoma during acquisition of therapy resistance - dependent on the transcription factor AP-1 biorxiv.org/content/10.1101/… (1/9)
Jose Orgaz retweeted
Cell membrane protrusions called “blebs” act as fists to help melanoma cells tunnel sciencenews.org/article/canc…
Very cool and important work from @MariaDMayan lab showing that Connexin43 enhances response to MAPKi in melanoma and other cancers. congrats @adrianvarelavaz @MariaDMayan and the rest of the team!
Jose Orgaz retweeted
Very pleased to announce a new #postdoc position to join my Advanced Functional Imaging team at
@KingsCollegeLon. The successful candidate will construct a 3-Photon FLIM system to interrogate 3D cell culture models. RTs very much appreciated. @UKRI_News kcl.ac.uk/jobs/092525-post-d…
Jose Orgaz retweeted
The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic & imprecise. Here we dig deeper into the events leading to cancer mortality
nature.com/articles/s41568-0… 1/2
Jose Orgaz retweeted
Ever wonder about the mechanics of immune cell #migration? @AlexiaCaillier, @pwoakes @LoyolaChicago and colleagues find T cells form integrin mediated focal adhesions to pull themselves through confined spaces. hubs.la/Q02Cjd1r0
#Immunology #Adhesion
Jose Orgaz retweeted
🚀Join @QMBCI as a Data Scientist! Work with Prof Claude Chelala, Vivek Singh and @Omaiques.
Fantastic opportunity to analyze multi-modal data from EHRs, molecular, and imaging datasets as part of @OPTIMA_oncology
qmul.ac.uk/jobs/vacancies/it…
#AI #DigitalPathology #Multimodal
Very cool paper!
@MegDrisc, Erik Welf, @MuthrNaturzSon , @kD3AN, @DanuserLab et al describe "worrying" as a mode of cell migration; melanoma cells literally dig tunnels.
The paper is out, combining cancer cell bio, computer vision (u-shape3D) and 3D microscopy:
authors.elsevier.com/c/1jFOh…
Jose Orgaz retweeted
I am delighted to open a PhD position at @QMULBartsTheLon in collaboration with @OliverMPearce @pearce_lab Please apply if you are interested in #ECM #digitalpathology #multiplex #earlydiagnosis
Jose Orgaz retweeted
Imaginad que alguien trabajó varios años en España y su empresa no pagó la cotización a la Seguridad Social.
Imaginad que muchos años después el Gobierno le dice que van a solucionar esa injusticia (un “día histórico”), pero que la cuota íntegra la tiene que pagar el trabajador.
Jose Orgaz retweeted
Happy to share this opportunity to join our team. Please apply if you are interested, or re-post if you are not on the look out for a new job crick.wd3.myworkdayjobs.com/…
Jose Orgaz retweeted
Interested in doing a PhD on cell senescence in our lab @LabPalmero @IIBmCSICUAM? We are hiring!
