ANTHROPIC BUILDS BIOLOGY LAB TO PUSH AI INTO DRUG DEVELOPMENT Anthropic has quietly established a Bay Area wet lab, moving its life-sciences ambitions beyond computer simulations and into physical biological experiments. The company wants Claude to direct laboratory robots with limited human intervention, potentially accelerating research into rare and traditionally “undruggable” diseases. Anthropic says it will focus on preclinical research rather than clinical trials, avoiding direct competition with pharmaceutical companies.

Going to YC demo day and just changed my profile to say “AC in office and home”.

Git at Scale (by cursor) has been one of the most interesting blog posts i've read in a while. It came right when I was frustrated with Shopify's internal git system. As an exercise, I've implemented it over the weekend as open source. It's a single rust binary that you can point at any S3 type object store. It uses WAL and CAS primitives and requires no other data store. It also implements bundle-uri so large git repos (like our mono) are very fast to download as a chain of static bundles. Also comes with basic familiar UX. github.com/tobi/walgit

open a bay area coffee shop called us-west-1.

Today, @FinCENnews issued a final rule that permanently removes the requirement for U.S. companies and U.S. persons to report beneficial ownership information. FinCEN today also announced that it will delete previously reported information by U.S. persons from the beneficial ownership information database.

Time for the classic Anthropic tale: "We couldn't *possibly* release this powerful tool. That's irresponsible. [5 mins later] Now that OpenAI has released their equally powerful tool, we must ensure *responsible* people are in charge, by releasing our own powerful tool."

software engineering in 2026: - your package manager is compromised - your cloud provider blocks your account - github itself is hacked software is solved

Tax season is here and a connector is all it takes to make @claudeai way more useful. Checkout what we just shipped: Connect TurboTax or Aiwyn Tax (formerly Column Tax) to Claude to estimate your refund, see what you may owe, and get a better understanding on the forms before you file.

those of you who never worked in tech during zirp will never understand this era. $5 ubers, $3 door dash lunches, enough scooters you could(and did) fill the bay. we were living like those post war boomers in million dollar homes paying $30 in property taxes. you could demand that your ceo opine on politics in #general and would go on strike if he forced you to work. you couldn’t walk down south park without tripping on a term sheet. we had so much money we were printing code on paper and sticking it in a vacuum sealed rocket launcher into space just for kicks. one click checkout was enough of an idea to burn $10m a month, wework was buying wave pools, you could buy mattresses at a loss, you could get a juice packet squeezer for $700. the zuck was surfing every day in hawaii.

Worries that software developer jobs are going away are backwards. There is SO MUCH software to build right now, that previously wasn't possible (uses AI directly) or wasn't cost-effective (too niche). We're going to have more developers, and orders of magnitude more software.

I'm former general counsel of Army, former Undersecretary of Army, former Undersec of Defense. Not sure if that makes me a nat sec "expert." But @nabla_theta interpretation is the right one, IMO.