@Jon_LP

Bioinformatics mostly

Joined July 2012
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  • Following205
  • Followers73
11Media
(1/2) How is epigenetic memory maintained across generations? 🧬 Our latest study reveals the role of SET-24, a SET domain-containing protein in C. elegans, in preserving germline integrity and small RNA-driven epigenetic silencing. Read more in our preprint!!
Chenming Zeng@ChenmingZeng27 Mar 2025
Delighted to share our latest preprint on the catalytically inactive SET domain protein SET-24 and its interactor, HCF-1, in maintaining transgenerational epigenetic memory, regulating histone modification and small RNAs. @ericmiskalab biorxiv.org/content/10.1101/…

A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory

Epigenetic information can be inherited through a process known as transgenerational epigenetic inheritance (TEI). TEI can be initiated and maintained by small RNAs and histone modifications. The...

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Just in case anyone is still here, check our latest preprint, right on time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. biorxiv.org/content/10.1101/… Short 🧵 with highlights.
bioRxiv Evobio@biorxiv_evobio18 Dec 2024
Transposable elements drive regulatory and functional innovation of F-box genes biorxiv.org/cgi/content/shor… #biorxiv_evobio
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How does AlphaFold3 predict the structures of proteins, DNA/RNA, ligands and other biomolecules? I did a deep dive into protein folding, how AlphaFold works and the new model. Here’s what I learned: (resource in thread)
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$ENVX …. 👀 This was a well done spaces. I didn’t expect to speak but appreciated being invited to share my thoughts. I shared a number of insights in addition to providing a detailed overview of my thesis. @EnovixBatteries
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🚨New preprint alert!!🚨 I am delighted to share my first postdoc research paper on the interaction between transposable elements (TEs) and piRNAs in African cichlid fishes 🐠🐠 Link here: biorxiv.org/content/10.1101/… Find the highlights in 🧵
An Astatotilapia calliptera male. Credit: M. Emília Santos

ALT An Astatotilapia calliptera male. Credit: M. Emília Santos

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So excited to bring my contemplations on #lncRNA role in #lungcancer and #lungdevelopment to #RNAUK2024 🤩🤩 Thank you for the opportunity! – at North West, England
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Great start to #KSRNAMod24 Keystone RNA modification meeting in amazing Banff 🏔️😎 #RNA #Epitranscriptomics
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Very happy that my first contribution to the cichlid community is out🐠🐟🐠. This review was the outcome of the Genome editing workshop at @Cichlid2022. We hope it will be useful for the community! Check @_Bethan_Clark's thread for details.
Bethan Clark@_Bethan_Clark29 Nov 2023
Excited to say our review of genome editing in cichlid fishes, focusing on CRISPR/Cas9 tech, is now published in @RSocPublishing #OpenBiology! Link here: royalsocietypublishing.org/d… Some highlights in🧵
A screenshot of the title "Genome editing in East African cichlids and tilapias: state-of-the-art and future directions | Bethan Clark, Muktai Kuwalekar, Bettina FIscher, Joost Woltering, Jakob Biran, Scott Juntti, Claudius Kratochwil, M. Emilia Santos, and Miguel Vasconcelos Almeida"

ALT A screenshot of the title "Genome editing in East African cichlids and tilapias: state-of-the-art and future directions | Bethan Clark, Muktai Kuwalekar, Bettina FIscher, Joost Woltering, Jakob Biran, Scott Juntti, Claudius Kratochwil, M. Emilia Santos, and Miguel Vasconcelos Almeida"

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Replying to @migueldvalmeida
@migueldvalmeida @ericmiskalab @CamBiochem speaking at the Dark Matter of the Genome session about his work on TEs in cichlids 🐟🐠🐡
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Help! Looking for a Comms coordinator to work with me and the team at @CamBiochem @Cambridge_SBS @Cambridge_Uni. Please RT!
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Hot off the pre-press🔥 #Chromatin tinyurl.com/efwe4je7 We provide the first evidence that inhibition of UBR-5 or HECD-1 can restore development to adulthood in #Celegans SWI/SNF mutants that otherwise die as embryos or arrest development at early developmental stages. A 🧵:
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Very excited to start my new role as Head of the Department of Biochemistry at the University of Cambridge @CamBiochem @Cambridge_Uni. More news to follow shortly. 😄
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LiquidText (liquidtext.net) - This is where I keep all my PDFs and notes on books/whitepapers/blogs etc, I have workspaces for things I'm interested in "appsec, APIs, etc...",you can 'pull out' text from different sources and visually place it together w/ your notes
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1/ Do you want to know if a variant will affect the structure and function of a protein? We’ve got lots of tools and #data in @ensembl to help you investigate and we’re here to show you how! A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining🧬
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The most powerful feature that Twitter has: Advanced search Until recently I hadn't even heard of it, but now I use it all the time. Here are 6 twitter advanced search features that will revolutionise the way you search for what to read: 🧵👇
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Say hi to @hip_ct: 3D imaging intact human tissues down to cellular resolution (see this 🧠 👇) now in @naturemethods: nature.com/articles/s41592-0… Excited to play a small part in this fab work by @Claire_L_Walsh, Prof Peter Lee & many others at @CABI_UCL, @esrfsynchrotron + beyond – at Camden Town, London
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How the solar system moves in space relative to galactic center by Dawn__Amber
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Meet the "Bagworm Caterpillar". It collects and saws little sticks to construct elaborate spiral log cabins to live in. They build their homes out of silk, sand, soil, and plant materials.
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The extraordinary Picasso bug is native to Sub-Saharan Africa & releases a noxious stink if disturbed.
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——— How confident are you in your crop genome assemblies? See what Jeremy Schmutz @hudsonalpha discovered upon re-assembling some older wheatgrass & rice genomes with HiFi sequencing. Click here to watch: bit.ly/3fNyrrx

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