
PDRA UoS bioremediation | Previously @LSTMnews | PhD RNAi UoSheffield |Biochem/tech βοΈβοΈ | Former EiC @MotionPod | @JohnSefParkGrn π| He/him π³οΈβπ |
Sheffield, England
Joined October 2019
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I now have a separate account for all things @LiverpoolGreens! Won't be doing a lot with it until the new year but follows are much appreciated in the meantime ππ
xitter.cf/JohnSefParkGrn?t=S_nyQβ¦ β at Liverpool, England
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Starting to write up the first mechanistic paper from my lab about endosomal PI(3)P: Retromer tubules (Vps35) budding from PI(3)P positive sorting endosomes with Actin at the neck. When PI(3)P homeostasis is perturbed this organisation breaks down and cells cant recycle cargo
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
My favourite image of the week, algae in microdropletsβ¦π§ͺ
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Last night John Howard spoke at Pint of Science πΊπ§ͺ: βThe Circle of (Micro)life - how microbe cooperation could help pollution remediation & agriculture." More: wix.to/C0KX5vf #PintOfScience #Microbes #SciComm
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Beers to βendβ the weekβ¦except having to work Saturday π
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Engineering synthetic co-cultures to be "needy" leads to unexpected consequences. We barely scratch the surface here, but get some interesting insights #biotech
π§ͺ sciencedirect.com/science/arβ¦
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
More outsourcing of critical thinking to chat bots that do not give any creative or actually inspiring feedback. True innovation will come to an end as people get more and more dependent on LLM to tell them what they want to hear.
BIG ANNOUNCEMENTπ£: I havenβt been this excited to be part of something new in 15 yearsβ¦ Thrilled to reveal the passion project Iβve been working on for the past year and a half!ππ₯³ It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe youβve noticed from my stupid jokesβ¦ :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... Itβs clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into βqedβ a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other peopleβs papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Letβs harness qed to put the power back in the scientistsβ hands, to do, to read & to publish science on our own terms. Iβm dying for you to TRY IT, and itβs very simple - just drop a paper (the link to the website is in the repliesπ) - itβs completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and letβs be the revolution π«΅!
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
70 years ago, a woman discovered the structure of DNA.
But 2 Cambridge men stole her work and won the Nobel Prize.
She was erased from history and died of cancer.
Hereβs how the biggest theft in science buried Rosalind Franklinβs name in historyβ¦ π§΅u
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Pace of parks' protection plan criticised:
bbc.co.uk/news/articles/c0lzβ¦
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Tomorrow is by-election day in Hunts Cross and Much Woolton. Vote for Mike Bates of the Green Party for a greener, healthier Liverpool
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
5 years after herbicide use ended, Hoylake foreshore is thriving:
240+ plant species β
42k tonnes of sand captured annually, saving Β£45k β
Home to 2% of UKβs embryonic dunes β
Peat soils forming β
30ha of rare habitat = biodiversity, protection, carbon capture π±β€οΈ
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
A day of trying to salt routes through ice on pavements at junctions around Lark Lane (we'll see how well that works or not π
), unblocking drainage grates in the park, & checking on a fence that was mended a little while back. β at Liverpool, England
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Happy New Year!
Got a free afternoon? Today's your last chance to visit the Maritime & Slavery museums for several years!
Huge programme of works ahead, including moving the Slavery museum to a new bigger home just round the corner
liverpoolecho.co.uk/news/livβ¦
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
.@hannes_maib et al present a toolkit for visualization of phosphoinositides in fixed cells & tissue, enabling multiplex & super-resolution characterization of these signaling #lipid hubs.la/Q02_5lKD0
Part of the Year in Cell Biology: hubs.la/Q02_5l790
#CellBio2024
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
Incredibly honoured to have my first paper as PI highlighted in this collection! The idea was do a quick tool paper as start into independence and it turned out to be much more useful than I thought. Read about how to use recombinant biosensors to stain for lipids in fixed cells!
Our annual collection highlights twelve of the most outstanding papers that showcase the exceptional range and quality of research published by JCB. We are delighted to serve as an independent venue for the awe-inspiring world of cell biology! hubs.la/Q02_fVs30
#CellBio2024
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
I've made Parks & the tree maintenance people within the council aware of the fallen tree across the path in Sefton Park so it can be dealt with. There's obviously a list of stuff after the storms & more dangerous things elsewhere in the city will get done first
@ILoveSeftonPark
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
OVER THE MOON! π
Golden bog-moss (Sphagnum pulchrum), a nationally v rare beastie, was presumed extinct on Britainβs 3rd largest raised bogβ¦
That is, until today, where I stumbled upon this teeny area where itβs clinging on for dear life! Isnβt it a beaut? ππ±
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
PI3K dependent rearrangement of the actin cytoskeleton following the addition of Class I PAK kinase-inhibitor. Please read about it in our pre-print!
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
"We placed tracking devices in 40 bundles of soft plastic packaging & dropped them at front-of-store collection points at @sainsburys and @Tesco across England.... 70% of the tracked bundles that reached a final destination were burnt, not recycled" π€¦ββοΈπ€
you.38degrees.org.uk/petitioβ¦
Dr John D Howard π¨βπ¬πΉπ³οΈβππ³οΈββ§οΈπΊπ¦π΅πΈπ retweeted
The 2024 #NobelPrize in Physiology or Medicine focuses on the discovery of a vital regulatory mechanism used in cells to control gene activity. Genetic information flows from DNA to messenger RNA (mRNA), via a process called transcription, and then on to the cellular machinery for protein production. There, mRNAs are translated so that proteins are made according to the genetic instructions stored in DNA. Since the mid-20th century, several of the most fundamental scientific discoveries have explained how these processes work.
In 1993, this year's Nobel Prize laureates published unexpected findings describing a new level of gene regulation, which turned out to be highly significant and conserved throughout evolution. They discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation.
Read more: bit.ly/4dlPE6f
































