@JoeThorntonLab

Evolution and biochemistry. Reconstructing ancestral proteins. "Training" scientists. UChicago faculty. Ambivalent about twitter.

 Chicago, IL
thorntonlab.org
Joined May 2020
  • Tweets156
  • Following94
  • Followers1.6K
31Media
My first first-author paper is out! It was an amazing collaborative effort with a lot of amazing people including @ArvindSPillai1 and @JoeThorntonLab. Please read if you like things involving evolution and biochemistry. pnas.org/doi/10.1073/pnas.24…
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Scientists at universities that have raised graduate student stipends: What have your administrations done to mitigate the costs to lab budgets so that the science itself doesn’t have to be curtailed? Examples of best practices would be appreciated.
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If a univ. increases stipend by 15k per year with no compensation to labs, it also gives itself a big raise in overhead costs (~10k per year per student), which it takes from our grants, too. Does it really cost the university more to administer a higher stipend?
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Have they reduced the graduate tuition they take from your grant budgets? Reduced the overhead charges (typically 55-80%) that they impose on student stipends? Reduced the overhead they take on your salary as PI? Other ideas?
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I am looking for *two* postdocs to join my lab at @VT_Biology next summer/fall. We work on the molecular basis of coloration and toxicity in poison-dart frogs. Please RT!! Job ad: tinyurl.com/mt28bdky Application link: tinyurl.com/3xs7tp23
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We are thrilled to congratulate our very own Yeonwoo Park @whatdoidohaha for winning UChicago's Best Dissertation Award across the entire Biological Sciences Division.
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In his first chapter, Yeonwoo discovered epistatic drift: the effects of most mutations wander gradually, randomly, and neutrally from their initial effects as proteins amass substitutions across long evolutionary timescales. bit.ly/42D9lkt
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Yeonwoo's second chapter introduces a new, improved method to dissect the genetic architecture of proteins - including the extent of epistasis - from deep mutational scans. The findings are very surprising. Stay tuned for the paper very soon. We are very proud of you, Yeonwoo!
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Congratulations, Carlos! (And to all the awardees. This will be a great symposium.)
Carlos Cortez@carway2nar
21 May 2023
So honored to have been selected! To all attending #smbe2023, I can’t wait to share my work with you.
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My lab works on the evolution of the proteins that enable microbial life. We resurrect ancient proteins and study their properties. If that sounds interesting to you, apply here - we are recruiting!
IMPRS-μLife@IMPRS_Mic
1 Dec 2022
Are you interested in doing exciting research in modern microbiology? Do you hold an MSc or equiv in biology, biochemistry, genetics, bioinformatics, chemistry, physics or another relevant field? Apply now for 3-year fully-funded PhD projects @ imprs-marburg.de! Pls RT
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Quick fix: Universities stop charging overhead on grad student stipends paid on government grants. Every student can then get an immediate 50-70% raise — revenue-neutral for PIs, science, and society.
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In addition to the huge overhead charge on stipends, the university also takes tuition for student workers out of the same grants, even when they’re not taking classes.
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The deaths of 17 medieval Jews: An incredible new genetics paper has just dropped: The earliest Jewish genomes and the story of where they are from and how they died is incredibly important, and central to the origin of contemporary antisemitic conspiracy hatred. 🧵
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Nuestro artículo en @ScienceMagazine: Medimos los cambios en el efecto de todas las mutaciones posibles a través de 700 millones de años de evolución de una proteína. El objetivo era evaluar la epistasis, la contingencia y la predictibilidad evolutiva.🧵 science.org/doi/10.1126/scie…

Epistatic drift causes gradual decay of predictability in protein evolution

The effect and fate of most mutations gradually become unpredictable as proteins evolve.

science.org
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El padre de Yeonwoo, el artista Youngdae Park, hizo este hermoso cuadro representando la contingencia causada por la deriva epistática. Los efectos de las mutaciones cambian aleatoriamente en el tiempo (líneas rojas) sobre un flujo constante de cambio en otros sitios.
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Acá está el enlace del artículo. cpb-us-w2.wpmucdn.com/voices…
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