Indianapolis, IN
Joined November 2019
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Ji Zhang Lab retweeted
Asparagine depletion is a cornerstone of treatment for Acute Lymphoblastic Leukemia (ALL), yet leukemic cells often develop resistance
doi.org/10.1172/jci.insight.…
Here, Rodney Claude @ScienceGuyRod, Sankalp Srivastava @darwinpwndyou, Ji Zhang @JiZhangLab & team @IUMedSchool explore the mechanisms for L-asparaginase resistance and establish a strategy that prevents leukemia cells from producing their own amino acid—the treatment synergizes with traditional chemoagents in vivo.
#ALL
It is a great pleasure to share our recent work by Rodney Claude @ScienceGuyRod and Sankalp Srivastava @darwinpwndyou , published at JCI Insight @JCI_insight
insight.jci.org/articles/vie…
There are two major findings in this story.
2. Combining L-asparaginase with ASX-173, a newly developed ASNS inhibitor, significantly delays disease progression in ASNS-high ALL models in vivo, without prohibitive toxicity.
1. Despite initial efficacy of GCN2 inhibition in sensitizing acute lymphoblastic leukemia (ALL) cells to L-asparaginase treatment, a subset of Gcn2-deficient cells express ASNS at high levels in a Gcn2-independent manner, which eventually drives therapeutic resistance.
Congratulations to Rodney Claude @ScienceGuyRod . You are officially a doctor now. I am so proud of you. I hope you will enjoy the next stage of your career journey as a PhD.
Ji Zhang Lab retweeted
Several undergraduate students joined us @IUDeptPeds this summer for 8-week internships with our faculty and research experts, gaining hands-on experience in the world of science and medicine. Read about some of their experiences: medicine.iu.edu/blogs/pediat…
Ji Zhang Lab retweeted
With a new $3.2M NHLBI grant to study low oxygen's benefits on blood stem cells, @IUMedSchool @IUDeptPeds scientists aim to expand the reach of advanced stem cell therapies and develop new strategies for treating a range of blood disorders. Read the news: medicine.iu.edu/news/2025/01…
Ji Zhang Lab retweeted
The 3rd Midwest Metabolism Meeting is officially announced @LurieCancer! This exciting event is set to take place @NUFeinbergMed in Chicago on Sept 19th. All postdocs and students from the Midwest region are invited to submit their abstracts by March 1st! cancer.northwestern.edu/even…
Big congratulations to Rodney Claude @ScienceGuyRod , my 2nd graduate student, who passed his qualifying exam today. Now, you are officially a Ph.D. candidate. I am so proud of you. @IUWellsCenter @IUSM_Biochem
Ji Zhang Lab retweeted
Online now! Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response dlvr.it/StKN8j
Ji Zhang Lab retweeted
Join us tomorrow & Thursday to hear final presentations from 40+ interns from the Wells Summer Internship and Medical Physician Engineers, Scientists and Clinicians Preparatory (MPESC-Prep) programs. We can't wait to discover what they learned this summer! 🧬🔬🥼
Asparagine starvation suppresses histone demethylation through iron de... sciencedirect.com/science/ar…
This is an awesome symposium on ferroptosis and cell death. The registration is free.
📣 Symposium Announcement
Please join us in Ann Arbor @UMich on May 25th for a 1-day meeting on “Metabolic and Immunological Impacts on Ferroptosis and Cell Death”. See the awesome speaker line-up below. Register for FREE at link: tinyurl.com/2023CellDeathReg…
Please spread the word!
Congratulations to Sankalp Srivastava @darwinpwndyou for a solid defense today. Now, we can officially call you Dr. Srivastava. I am very proud of being your mentor. @IUWellsCenter @IUCancerCenter
Ji Zhang Lab retweeted
Join us today for the thesis defense of Sankalp Srivastava. He will present his work on "The essential role of the non-essential amino acid asparagine in lymphoid malignancies" performed under the mentorship of Dr. Ji Zhang. 1pm, R3 C203. @IUCancerCenter @IUMedResearch
Ji Zhang Lab retweeted
We're about one week away from our Summer #Internship Program's 2023 application deadline. That means there's still time to apply! medicine.iu.edu/research-cen…
#MedTwitter #ScienceTwitter
Help us spread the word! Our 2023 Summer #Internship Program is open for applications. Undergrad students with a passion for #science are encouraged to apply: medicine.iu.edu/research-cen…
ALT Cartoon of a female scientist looking through a microscope. Accompanied by text that reads, "Wells Center 2023 Summer Internship. Hands-on experience in pediatric bench research. Undergrad students are eligible. 8-week program from June 5 to July 28, 2023. Applications close on January 21, 2023.
Ji Zhang Lab retweeted
Ji Zhang (@JiZhang32146855), PhD, and his colleagues identify two distinct metabolic subclasses among neoplastic populations within individual human and mouse tumors and what it means for pancreatic cancer in @NatureCancer. Learn more: ow.ly/3CKA50LRk7H.
Ji Zhang Lab retweeted
Help us spread the word! Our 2023 Summer #Internship Program is open for applications. Undergrad students with a passion for #science are encouraged to apply: medicine.iu.edu/research-cen…
ALT Cartoon of a female scientist looking through a microscope. Accompanied by text that reads, "Wells Center 2023 Summer Internship. Hands-on experience in pediatric bench research. Undergrad students are eligible. 8-week program from June 5 to July 28, 2023. Applications close on January 21, 2023.