jesper tegner (@JesperTegner) header
jesper tegner (@JesperTegner) profile picture

Decoding & Reprogramming Existence of Living Systems, and Minds Emerging in Universe-- Natural and Artificial Systems https://xitter.cf/t.co/LZP3kACQFy…

KAUST, Karolinska & SciLifeLab
Joined January 2013
Photo by jesper tegner (@JesperTegner)Photo by jesper tegner (@JesperTegner)Photo by jesper tegner (@JesperTegner)Photo by jesper tegner (@JesperTegner)Photo by jesper tegner (@JesperTegner)
Exploring the role of large language models in the scientific method
npj Artificial Intelligence is open for submission! It considers research that explores all aspects of Artificial Intelligence research and development including application and implementation of these technologies. buff.ly/3T5Ci6Z
2
2
84
jesper tegner retweeted
What if signs of disease could be identified and interpreted earlier? KAUST researchers are combining biology, medicine, AI and bioelectronics to explore patterns and signals that could offer new insights into health and neurodegenerative disease.
1
1
4
1,260
jesper tegner retweeted
Only about a quarter of human diseases have an approved therapy. By some estimates it's a few percent. Most of those treatments slow a disease rather than stop it. Closing that gap is what the AI-cures-everything story promises. Build a system smart enough and the cures hidden in what we already know will fall out. I have worked at the intersection of machine learning and biology for three decades, and I believe #AI will eventually transform human health. The capabilities arriving now are extraordinary. But the promise rests on an assumption that is simply false: that we already understand human biology well enough for a clever enough reasoner to find the answers in it. We don't. More than 90% of drugs entering clinical trials fail, a number that has barely moved in decades. In the large majority of those failures the molecule was engineered just fine. The mechanism it targeted was wrong. We are doing a pretty good job at manufacturing keys, but they are generally for the wrong locks. And because nobody wants to fail in the clinic, the industry has retreated to the locks it already trusts: 38 targets now have more than 50 programs against each of them, while the number of novel targets advanced per year fell from roughly 100 in 2015 to about 30 in 2024. AI will not reason its way past this. Biology wasn't engineered. It is the product of billions of years of messy, stochastic evolution, and the variation that produced is too vast and too idiosyncratic to work out in the abstract. You have to measure it. Aimed at a biology this thinly sampled, AI will mostly help us generate failures faster. I founded @insitro because getting to the right locks requires a different kind of system. We generate multimodal human and cellular data at scale, use machine learning to find causal drivers of disease, and test those hypotheses experimentally. Virtual Human™ is built for causal discovery; TherML™ turns what it finds into the right therapeutic intervention. It is working: first-in-class programs internally and with partners, three #ALS targets that Virtual Human™ identified and @bmsnews nominated, and additional collaborations with @EliLillyandCo and @GileadSciences . Today we are launching Deep Phenotype: Scaled Biology, Deep Causality. Issue one is "Drug Discovery Has No Magic Wands," the first half of a two-part essay on the magical thinking currently running through our field and what I think it will actually take. After that you will hear from insitro's own scientists and engineers, people who work across computation and experiment because the problem requires both. Getting this right is hard, and we do not have all of it worked out. I hope you will follow along and think it through with us. DeepPhenotype.Substack.com
25
84
25
405
81,407
jesper tegner retweeted
🧠 Can nature inspire the future of AI? A new @Nature study by @JesperTegner at @KAUST_News explores how biological systems could shape more efficient and resilient AI. arabnews.com/node/2651209/bu… #KAUST #BioMed #AI
3
6
306
jesper tegner retweeted
KAUST students Abdelrahman Sabbagh and Salem Al-Saqaf won second place in @@TheGarageKSA Challenge, a national competition with more than 200 participants, and earned direct incubation at The Garage innovation hub. Their digital receipt platform supports Saudi Vision 2030 by reducing paper waste and advancing sustainable technology.
5
16
3,753
jesper tegner retweeted
I want to clarify my thoughts on problem-solving in mathematics, and the potential consequences of AI for the field. For context, I’m quoting here my post in reply to Daniel Litt (who, echoing others, I find very clear, grounded, and insightful in his thinking). The claim The short version is that I think problem-solving is an immense, and pervasive part of modern mathematical research. Consequently, if human problem-solving disappears by virtue of the AIs becoming strictly and substantially better at it, then most of the time currently spent by modern mathematical researchers will have to be spent on an activity that is altogether pretty different. Whether such an activity is viable as a professional endeavour is something I am unsure of, but strongly encourage others to think about and try to envision, so that if/when the time comes, we can steer such a future into being. Allow me to make this somewhat concrete: by problem-solving I mean questions of the form “is T true? If so find a proof. If not, find a disproof.” where T is a precise mathematical statement. I’ll also include “find an example of S, if there is one” where S is some structure (variety/category/property/isomorphism/….). The argument Ok. Now as I said (and some have echoed) I spend ~all of my time problem-solving as my primary goal. This has sub-goals, but my entire main research field disappears if someone solves the Zilber-Pink Conjecture in its more general form. This is a single conjecture (precisely stated!) and lots of mathematicians, postdocs, and graduate students are engaged in picking apart special cases of it, trying strategies, finding analogies to develop intuition, etc.. Of course, lots of motivation and intuition and analogizing and understanding have gone into deciding to make the ZP conjecture a focus! But the fact remains that this is now what is being worked on ~all of the time by this community. This is true of many mathematicians. They have a problem (or ten) and spend most of their time doing it. If someone solves it, they have to find a different problem. This can be a big, disorienting process involving a lot of energy, and is neither trivial nor always fun (though often rewarding in the end). People have written a lot about Theory building vs. Problem-solving, and I want to first of all clarify I have nothing against theory building or theory builders! It is a valuable part of mathematics, and while there are differences in perspective between the “camps” there is way more mutual respect and agreement. However, I gather there is a perception that theory-builders spend most of their time not-problem-solving, and I think this is largely untrue. Now I’m not a theory-builder primarily (though I’ve partaken a LITTLE BIT by necessity) so I am outside of my comfort zone. As such, I apologize for mistakes and welcome corrections! But theory-building constantly runs through problem-solving. Let’s say you want to define the right notion of a cohomology theory. Of course you must make candidate definitions. But then what does it mean for it to be the right one? Well, you start asking if it has natural properties. These are T statements. Does it satisfy a Kunneth formula? Is it functorial in the right way? When you have the wrong one you have to find the properties it’s missing, and when you have the right one you have to prove that it indeed has those properties. Again, I am not saying nor do I believe that this makes problem-solving “real math” and theory-building lesser. I am just trying to draw attention to the way I think research mathematicians operate, and mathematics is practiced. To put all this a different way, imagine you had access to an AI oracle that could resolve statements T, but somehow lacked any creativity to build technology or make definitions (I think this is unlikely, but for the purpose of this thought experiment lets imagine it). How would your mathematics change, if you were a theory builder? Well, you make a definition, and want to know if it’s the right one. You immediately ask your oracle a thousand questions. From “are these basic properties true” to “ooh, so is this deep conjecture true?” and start getting back answers, and amending your definitions. You could invent and resolve entire research directions in days. But the confusion you would have had to push through to flesh out your theory would largely (probably not entirely) be instantly resolved and the whole process sped up tremendously by your oracle. A big part of the process would be gone. This is very very different to modern mathematics. One more thought This post is too long already, but I’ve seen some people say that they only do mathematics to find truth and others valourize that as the only virtuous way to be. I do not do mathematics only to find truth. I do it largely because I enjoy it and I am good at it. I also find it beautiful and am grateful I get to spend my days understanding beautiful things. But I enjoy the challenge, the process, resolving confusions, finding strategies, grappling with problems. I would like to push for this being de-stigmatized. Mathematicians are people who need money, housing, food, love, exercise, and a great deal of other stuff including various forms of meaning. There are many people whose primary enjoyment of math comes through problem solving in one of its incarnations. If that disappears, that is not a trivial issue and many of them might not want to do it anymore (even if there were some way to proceed).
Replying to @littmath @willdepue
Hey @littmath , I've seen you post this sentiment a lot, and want to push back a bit (in my formal twitter-posting debut!). So my math career has almost entirely been "solve this problem". Now, of course there is an enormous amount of other activities such as formulating toy problems, identifying which ones are worthwhile, theory building, and selection and formulation of the original problems. But typically for 80%+ of my time, I know what problem I'm trying to solve and am just trying to solve it. I've seen the view expressed a lot that this is sort of not-the-main-point, and is just a part of figuring out the appropriate mathematical structure and phenomena. It's not that this is untenable, but I feel this is a somewhat overstated perspective. For one thing, talks (almost) always start/end with "here is the theorem I have proven". Its not that the view you have of math isn't coherent, but I could equally formulate the point of math as 1. Find a fun phenomenon 2. Make a problem capturing it as nicely as possible 3. Solve it, possibly by building theories and formulating sub-problems. so that problem-solving become the central point of math, and theory building as a side-effect. Indeed, mathematicians offer measure the value of a theory by the problems it can solve. This is at least an important part of a theory. I actually feel you and I are not far apart in our mathematical taste, so I'm curious how much we actually disagree here (I suspect the answer is "some"). Sorry for the overly long post! I am very much a twitter-newbie and will have to adjust.
38
188
38
1,132
368,486
jesper tegner retweeted
The historic 90th CSH Symposium on AI in Biology at @CSHL has come to an end. After a decade of remarkable advances in AI x Bio, aspirations have become bolder than ever. The future looks bright but much work remains to turn hype into real-world progress. Thanks to all speakers!
4
18
4
140
16,460
I'm pretty excited about AI in Biology. I bet my research career on it. And now I'm betting my investment career on it! But somehow, spending this past week at CSHL's 90th symposium—which was exclusively dedicated to this topic this year—made me even more bullish! One of the most electric conferences I've been to in a while... maybe ever. Back-to-back talks from the top scientists and industry leaders in this field. Even though my job is to cover this domain, it was a visceral reminder of how quickly things are moving. Fantastic job curating and organizing by @pkoo562 and @TonyZador. My plan is to get some notes up on what I saw in the next week or two on CoB! 🧬
4
16
204
14,098
jesper tegner retweeted
Biology has a data problem — not a shortage, but fragmentation. A new “super transformer” concept from KAUST aims to unify genomics, imaging & cellular data into one AI model. From silos → systems thinking. 🔗 discovery.kaust.edu.sa/en/ar… #AI #BioTech #Bioinformatics @JesperTegner
3
8
321
Minimal algorithmic information loss methods for dimension reduction, ... sciencedirect.com/science/ar…
2
117
jesper tegner retweeted
Check out our latest featured research: *Bio-inspired network structures for next-generation AI* Featured in KAUST Discovery: discovery.kaust.edu.sa/en/ar… Related papers: 🧠💻Leveraging network motifs to improve artificial neural networks doi.org/10.1038/s41467-025-6… 🧠💻A 1,805-day exploration revealing how network structure shapes artificial neural networks go.nature.com/3WRr9Il #ArtificialIntelligence #NeuralNetworks #MachineLearning #BioInspiredAI @JesperTegner
1
4
244
A Perspective reviews recent and emerging developments in building multimodal foundation transformer models in genomics. @sabbaghtweets @VincenzoLagani @robert__lehmann @SumeerrKhan @JesperTegner nature.com/articles/s41592-0…
2
67
2
289
19,771
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity cell.com/immunity/fulltext/S…
1
6
449