@JenkinsonFLV

Using my cells to study cells 🧬 ~ Postdoc: histone mark inheritance @Grothlab ~ PhD: PP2A control of DNA replication @Zegermanlab

Joined February 2021
  • Tweets54
  • Following169
  • Followers113
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My PhD work is published today in Molecular Cell!! 🥳 A short thread 🧵 (1/12) cell.com/molecular-cell/full… #phosphatase #DNAreplication #cellcycle #PP2A #originfiring

Dephosphorylation of the pre-initiation complex is critical for origin firing

Across eukaryotes, cyclin-dependent kinase (CDK) activates replication initiation by phosphorylating two substrates, Sld2 and Sld3. Here Jenkinson et al. show that the reverse reaction, dephosphory...

cell.com
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Fion Jenkinson retweeted
Jakob Nilsson@NilssonLabCph3 Oct 2024
Our paper on PP2A-B55 substrate recognition out now. Great collaboration with @FurmanLab @torbenheick @KettenbachLab @jp_arulanandam. We integrate AlphaFold modelling and protein design with biochemical and cell based assays science.org/doi/10.1126/scia…

Substrate recognition principles for the PP2A-B55 protein phosphatase

α helices in PP2A-B55 substrates bind a conserved pocket on B55 through a common mechanism that is conserved in eukaryotes.

science.org
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We're hiring! We have a funded postdoc available and encourage anyone interested in epigenetics and/ or gametogenesis to apply. Experience in mouse genetics/ development especially welcome! Deadline: 1 October Apply here: jobportal.ku.dk/videnskabeli… Please retweet!
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We are recruiting a postdoc for a fully funded position in our group in beautiful Copenhagen! We encourage anyone interested in #DNAmethylation and/or #Bioinformatics to apply. Deadline: 17 September Apply here: employment.ku.dk/faculty/?sh… Please retweet!
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Nitika Taneja@Tanejalab6 Jul 2023
We are super excited to see our exciting breakthrough on de novo #heterochromatin at #replicationforks out now @NatureCellBio 💥Did you think heterochromatin formation was limited to specific regions and gene silencing? To know more, check out here 👉nature.com/articles/s41556-0…
Movies of 3-D reconstructed human nucleus, untreated (on left) or HU treated, 1mMHU-1h (on right) immunolabelled with H3K9ME3 (green) & EdU labeled (red) replicating regions & imaged using Super-resolution STED microscope.

ALT Movies of 3-D reconstructed human nucleus, untreated (on left) or HU treated, 1mMHU-1h (on right) immunolabelled with H3K9ME3 (green) & EdU labeled (red) replicating regions & imaged using Super-resolution STED microscope.

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Very grateful to have been awarded a @lundbeckfonden postdoc fellowship to identify critical factors in inheriting cell identity. Excited for my time ahead in the @GrothLab
Lundbeckfonden@lundbeckfonden19 Apr 2023
This will help boost Danish research within #neuroscience and brain-related fields, improve opportunities for young doctors to conduct clinical research, and to attract and retain international#talent. Congratulations! lundbeckfonden.com/grants-an… #dkforsk #dkvid
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CPR is a truly stellar place for science! Cutting edge technologies, blue skies and translational research, collaborative spirit.   Immensely sad that @novonordiskfond will close this scientific jewel. We will cherish the remaining time and #CPRlegacy 🏆
CPRatUCPH@UCPH_CPR17 Apr 2023
Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵
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The last couple of days has been some of the saddest in my scientific career. The news that NNF CPR will stop its operations in the coming years has come as a shock and with large ramifications.
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Fion Jenkinson retweeted
Cantley Lab@CantleyLab11 Jan 2023
We are delighted to share our work, now available in @Nature: nature.com/articles/s41586-0… Our scoring system can be accessed here: kinase-library.phosphosite.o… Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features! #TheKinaseLibrary #KL

An atlas of substrate specificities for the human serine/threonine kinome

Nature - Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by...

nature.com
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We are recruiting a #PhD student to join our new group! We encourage anyone interested in germ cells, development, and/ or #chromatin to apply. 🗓️ Deadline: 31 January Apply here: employment.ku.dk/phd/?show=1… Please share!
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I am really excited 🥳 that this work is now out in @NatureBiotech What used to be sci-fi is now possible! Profile 3 epigenetic modalities with single-cell resolution using sc-nano-CUT&Tag.
Nature Biotechnology
@NatureBiotech19 Dec 2022
Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag go.nature.com/3WvhLrO
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Massive thanks to all in the Zegerman lab’s ‘Team Phosphatase’ over the years, particularly Kang Wei & Barbara! Grateful for Miguel’s 👨‍💻 assistance & the facilities @CamBiochem & @GurdonInstitue. Finally, thanks to Phil for being a great supervisor on an awesome PhD project!
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Turns out I’m not so strong at correctly tagging things on Twitter: @GurdonInstitute , @MolecularCell - apologies
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Online Now: Dephosphorylation of the pre-initiation complex is critical for origin firing dlvr.it/SfgkLr

Dephosphorylation of the pre-initiation complex is critical for origin firing

Across eukaryotes, cyclin-dependent kinase (CDK) activates replication initiation by phosphorylating two substrates, Sld2 and Sld3. Here Jenkinson et al. show that the reverse reaction, dephosphory...

cell.com
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