@JenalLab

@urs_jenal lab. Signaling in bacterial infections @biozentrum, @UniBasel_en, Switzerland.

 Basel, Switzerland
biozentrum.unibas.ch/jenal
Joined January 2019
  • Tweets23
  • Following55
  • Followers1.1K
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Our new preprint is out @biorxivpreprint Coenzyme A depletion causes antibiotic tolerance in P. aeruginosa CoA metabolism, redox imbalance & antibiotic survival : a new axis for tolerance. doi.org/10.1101/2025.10.24.6… Thanks to our collaborators @biozentrum @UniBasel_en @ETH_en
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Build therapies & decode phage–host signaling. Jenal Lab (Biozentrum Basel) seeks 2 Postdocs: anti-biofilm drug discovery (structure-guided) and E. coli–phage c-di-GMP biology. Start Jan’26/ASAP. biozentrum.unibas.ch/open-po… #Microbiology
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🥼We're hiring! Join the @JenalLab at the Biozentrum, University of Basel, as a Technician in Cell Culture & Human Tissues (80-100%). Contribute to groundbreaking research on lung infections and antibiotic discovery. Starting Sept 2024. 📅Apply now: biped2.biozentrum.unibas.ch/…
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🦠Pathogenic bacterium Pseudomonas aeruginosa breaches lung defenses by targeting mucus producing goblet cells! Intracellular P. aeruginosa may evade immune system and antibiotic treatment, thereby driving chronic infections @NCCR_AntiResist @IHB_Research doi.org/10.1038/s41564-024-0…
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the article: nature.com/articles/s41564-0…
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Our c-di-GMP sensor story is finally out in @NatureComms: rdcu.be/dHsEh. Including new data demonstrating cdGreen2 as a convenient tool to study DGC and PDE activity in vitro. Great collaboration with @simon_vanvliet and @MaierLab!
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Twittertown has a new mayor—and it’s as if the Penguin has taken over Gotham, writes @davidfrum: theatlantic.com/ideas/archiv…

Why I Logged Off Twitter

Whatever Elon Musk does, users will be implicated in what happens to the site. That’s a responsibility we all have to take seriously.

theatlantic.com
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Happy to share our new piece of work: a robust, sensitive ratiometric c-di-GMP biosensor, cdGreen2. cdGreen2 allows monitoring of c-di-GMP dynamics over generations in various organisms. (1/2) biorxiv.org/content/10.1101/…
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Here an example of c-di-GMP oscillations over the Caulobacter crescentus cell cycle. High c-di-GMP in yellow/orange, low c-di-GMP in magenta. (2/2)
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Job advertisement: Postdoctoral researcher – Establishing novel 3D in vitro systems for respiratory bacterial infections (100%) ow.ly/Zyhy50DqUo3 @biozentrum @UniBasel_en @NCCR_AntiResist #Biozentrum #Basel #research #science #joboffer #postdoc #NCCRAntiresist #NCCR
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AntiResist, in collaboration with Roche Infectious Disease Discovery group, is hiring a Postdoctoral researcher to establish novel 3D in vitro systems for respiratory bacterial infections. Please check out the full ad on the University of Basel portal biped2.biozentrum.unibas.ch/…
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The Swiss winner in the “microscopy” category for #WikiScienceCompetition2019 is @BJ_Laventie. He is a researcher studying pathogenic bacteria. More: wikimedia.ch/en/news/wiki-sc… #wikisciencecompetition2019 #WSC2019 #microscopy @Wikipedia @wiki_science @JenalLab @biozentrum @unifr
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Inner “clockwork” sets the time for cell division in #Caulobacter: precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis. Check out our two latest papers: rdcu.be/b1tpP & pnas.org/content/117/2/1000 @UniBasel_en @biozentrum
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#NCCR "AntiResist": new approaches to combating antibiotic-resistant bacteria Home institution: University of Basel Federal funding 2020-2023: CHF 17 million snf.ch/en/researchinFocus/nc…
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2 positions available immediately on toxin-antitoxin systems in Pseudomonas aeruginosa: 1 PhD student in structural biology & biochemistry ow.ly/vxih50wKlUB 1 PostDoc in microbial single cell analysis & microfluidics ow.ly/Psxe50wKnem #Biozentrum #Basel #joboffer
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Congrats to our Master student Fabienne Estermann for winning the Public Choice Award of the Science Film Hackathon. Amazing work in just 3 days! “The Science of Love” youtu.be/kDqrhybw64c @ExposureSciFilm
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Congrats to our PhD student Christina Manner for her great Science communication movie created during the Science Film Hackathon. Wonderful example of Science communication with beautiful watercolor illustrations. “Lively Dinner Table” youtu.be/I7fPDvGnIOU @ExposureSciFilm

Lively Dinner Table - The Hybrids - ESFH Basel 2019

Christina Manner, Mehdi Khadraoui, Fabienne Fischer, Hossein - Heme...

youtube.com
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Thank you Chris @WatersLabMSU for discussing our work! @F1000Prime f1000.com/prime/734670121?ke…
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Divide and conquer nature.com/articles/s41579-0… A recent study reports that P. aeruginosa surface colonization triggers asymmetrical divisions, which generate specialized cell types — a ‘spreader’ for dissemination of the pathogen and a ‘striker’ that causes tissue damage @urs_jenal
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#Paeruginosa boosts c-di-GMP within seconds upon surface contact to activate adherent pili. Asymmetric division generates a striker (locally attacks tissues) and a spreader (remote colonization). More at @cellhostmicrobe cell.com/cell-host-microbe/f…
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