Javier Perez-Garcia

#Environment, #Microbiome and #Epithelial Barriers According to the Epithelial Barrier Theory, disruption of tight junctions by environmental toxins, such as detergents, pollutants, and microplastics, drives the disease pathogenesis of many chronic inflammatory conditions. This structural breakdown facilitates the translocation of allergens and pathogens through the epithelial barrier into deeper tissue, promoting microbial dysbiosis and sustained immune activation. The cover of this issue illustrates this critical interface by depicting the developing microbiome of a child. The artwork highlights the early "window of opportunity" in childhood, during which the development of a diverse microbiome and the maturation of the protective epithelial barriers shape long-term immunological health. Advancing our understanding of these processes is essential for developing novel preventive and therapeutic interventions. © M Oeggerli (Micronaut) 2022, supported by UHB (Pathology) and Bio-EM Lab, Biozentrum, University Basel. The March issue opens with the EAACI guidelines by Haahtela, O´Mahony, Traidl-Hoffmann et al., presenting the first EAACI recommendations on the significance of urban green spaces for immune health. Ha et al. provide a comprehensive review of the negative impact of wildfire smoke on atopic diseases and its effect on specific communities. Augustin et al. review our current knowledge on the impact of climate change and air quality on pollen allergies. Radauer et al., in their EAACI Task Force Report, summarize data on new allergens approved by the WHO/IUIS Allergen Nomenclature Sub-Committee between 2021 and 2024 and discuss recent developments in molecular allergy research. Hartiala et al. describe the most important indoor air determinants affecting health, and present the IDEAL cluster, which comprises seven EU-funded scientific projects on the topic of indoor air quality and human health. Perez-Garcia et al. evaluate the association between the nasal microbiome and air pollutants, meteorological conditions, and respiratory health in adolescents. Shibata et al. examine the association between airway microbiota and host DNA methylation in infants with severe bronchiolitis. Karaguzel et al. assess lung function in users of heat-not-burn tobacco and conventional cigarettes and investigate the molecular mechanisms of exposure to heat-not-burn tobacco products using animal and in vitro models. Chiang et al. identify links between per- and polyfluoroalkyl substances (PFAS) and sinonasal symptoms, providing population-based epidemiological evidence on their toxicological effects. Meng et al. examine the bidirectional association between seborrheic dermatitis and dermatologic, gastrointestinal, respiratory, and ocular epithelial barrier diseases using a large US administrative claims database. Leo et al. study the role of neurogenic inflammation mediator endothelin-1 in skin barrier impairment. Pat, Yazici and Babayev et al. investigate the effects of postbiotic strains, Bifidobacterium breve, Limosilactobacillus reuteri, and Ligilactobacillus salivarius, on skin barrier integrity and inflammatory responses using an ex vivo human skin model. Pat et al. assess the effect of aspartame on the biology, inflammation and epithelial barrier of gut epithelial cells. Leonardi et al. study the ocular microbiome in dupilumab-induced ocular surface disease. Miyake et al. identify phenotype-specific and shared gut microbial signatures in children with allergic rhinitis, including reduced diversity, loss of beneficial taxa, and altered short-chain fatty acids and immune-related pathways. Bakirtas et al. present a survey on environmental protective and risk factors and awareness related to epithelial barrier integrity, microbiome and allergic diseases. journalallergy.com

Allergy provides the readers with 19 free and open access articles in the March issue! Check out the articles and download freely with one click on the doi link. 1. Haahtela, T., O'Mahony, L., Traidl-Hoffmann, C., et al., EAACI Guidelines on the Importance of Green Space in Urban Environments for Allergy and Asthma Prevention. Allergy, 81: 635-650. doi.org/10.1111/all.70182 2. Ha, A., Balmes, J.R. and Wei, M.L. Wildfires and Atopic Diseases: A Review. Allergy, 81: 651-662. doi.org/10.1111/all.70116 3. Augustin, J., Gilge, S., Appel, H., et al., Climate Change, Air Quality, and Pollen Allergies—State of the Art and Recommendations for Research and Public Health. Allergy, 81: 663-683. doi.org/10.1111/all.70159 4. Radauer, C., Gadermaier, G., Goodman, R.E., et al., New Allergens Approved by the WHO/IUIS Allergen Nomenclature Sub-Committee in 2021–2024 and Their Significance for Future Diagnostics, Regulation, and Research. An EAACI Task Force Report. Allergy, 81: 684-699. doi.org/10.1111/all.70166 5. Hartiala, M., Elenius, V., Pesquera, A.A., et al., Exposures in Indoor Air Affecting Health. Allergy, 81: 700-719. doi.org/10.1111/all.70179 6. Teufelberger, A.R., Költgen, C., Babina, M. and Wolf, P. Prolonged IL-33 Exposure Switches the Secreted Mast Cell Cytokine Profile From Pro-Inflammatory to Pro-Tolerant. Allergy, 81: 720-733. doi.org/10.1111/all.70122 7. Nolasco, S., Fagone, E., Campisi, R., et al., Effect of the Arg16Gly β2-Adrenergic Receptor Polymorphism on Long-Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype-Stratified, Multicenter Study. Allergy, 81: 734-749. doi.org/10.1111/all.70071 8. Perez-Garcia, J., Bozack, A.K., Rifas-Shiman, S.L., et al., The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health. Allergy, 81: 750-763. doi.org/10.1111/all.70089 9. Karaguzel, D., Walewska, A., Sarac, B.E., et al., Heat-Not-Burn Tobacco Aerosols Induce Immune Dysregulation and Barrier Disruption Comparable to Conventional Cigarettes. Allergy, 81: 781-795. doi.org/10.1111/all.70174 10. Meng, S., Berna, R., Takeshita, J., et al., Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study. Allergy, 81: 808-817. doi.org/10.1111/all.70112 11. Pat, Y., Yazici, D., Babayev, H., et al., Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation. Allergy, 81: 830-847. doi.org/10.1111/all.70225 12. Burris, A.D., Diaz, N., Meddings, J.B., et al., Secretion of Peanut Protein With IgE Crosslinking Capacity in Human Milk. Allergy, 81: 861-873. doi.org/10.1111/all.70066 13. Pat, Y., Yazici, D., Zeyneloglu, C., et al., Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame. Allergy, 81: 884-901. doi.org/10.1111/all.70095 14. Adachi, T., Watanabe, S., Kuwabara, Y., et al., Exploring Patient and Public Involvement and Engagement in Allergy Research: Cross-Disease and Cross-Stakeholder Perspectives in Japan. Allergy, 81: 902-905. doi.org/10.1111/all.70064 15. Vijendra, A., Shobnam, N., Jordan, J., et al., Biomarkers Are Consistent With Patient-Reported Allergic Sensitization in Topical Steroid Withdrawal. Allergy, 81: 906-909. doi.org/10.1111/all.70068 16. Brigger, D., Steinmann, M., Roos, N., et al., Age-Related Increase in Anaphylaxis Severity Is Associated With Enhanced Sensitivity to Allergic Mediators. Allergy, 81: 910-913. doi.org/10.1111/all.70082 17. Leonardi, A., Frizzo, R., Cavarzeran, F., Ozkan, J. and Rosani, U. (2026), Ocular Microbiome in Dupilumab-Induced Ocular Surface Disease. Allergy, 81: 917-919. doi.org/10.1111/all.70104 18. Miyake, K., Watanabe, D., Otawa, S., et al., Gut Microbiome Alterations by Allergen Sensitisation and Symptom Severity in Paediatric Allergic Rhinitis. Allergy, 81: 925-929. doi.org/10.1111/all.70163 19. Bakirtas, A., Kiykim, A., Baskin, A.K., et al., A Survey on Environmental Protective and Risk Factors and Awareness Related to Epithelial Barrier Integrity, Microbiome and Allergic Diseases. Allergy, 81: 930-933. doi.org/10.1111/all.70190 #Allergy_journal Read all recent papers published in #Allergy here: journalallergy.com

📅 This Week in #Allergy 📚 Missed our latest content? Here's your weekend catch-up: 1. Open Access: The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health. Corresponding authors : Javier Perez-Garcia, Andres Cardenas. Read the article here: doi.org/10.1111/all.70089 2. Open Access: Basophils in Skin-Mediated Sensitization Drive Subsequent Lung Inflammation in Airway-Challenged Mice. E Da Choi, David Voehringer, Daniel Radtke. Read the article here: doi.org/10.1111/all.70093 3. The Sting Challenge Test: An EAACI Position Paper on Hymenoptera Venom Allergy. First author: Arantza Vega Castro; corresponding author: Christine Breynaert. Read the article here: doi.org/10.1111/all.70096 4. Genistein Reduced Eosinophilic Inflammation and Remodeling by Downregulating PAI-1 and TSLP. First author: Jung Yeon Han; corresponding author: Seong H. Cho. Read the article here: doi.org/10.1111/all.70098 #Allergy_journal #AllergyResearch journalallergy.com

Open Access: The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health. Corresponding authors : Javier Perez-Garcia, Andres Cardenas Read the article here: doi.org/10.1111/all.70089 This study evaluates the association of the nasal microbiome with air pollutants, meteorological conditions, and respiratory health in adolescents. Bacterial diversity is positively associated with hay fever and short-term NO2 exposure, and negatively with temperature. A Moraxella-dominated nasotype is linked to lower O3 exposure and higher temperature and humidity, whereas a Staphylococcus-dominated nasotype is associated with increased risk of aeroallergen sensitization. Staphylococcus, Corynebacterium, Pelomonas, Lactococcus, Lachnospiraceae (unclassified), and Faecalibacterium abundance are associated with both environmental exposures and respiratory traits. #Allergy_journal Read more articles published in #Allergy on the #microbiome here: journalallergy.com/barrier-a…