ALT The figure highlights the potential additional disease burden associated with delayed MBS (grey area) after successful weight reduction with OMM. People living with obesity typically continue to gain weight as the disease progresses (yellow line), a trajectory that is reversed when treated with highly effective OMMs (blue line). When OMMs are discontinued, weight gain resumes and it is projected that most of the weight lost during treatment is regained within the next 1–3 years while off treatment (red line). MBS is successful at any disease stage (green line); however, delaying MBS until weight regain is established increases the weight-related disease burden. OMM=obesity management medication. MBS=metabolic bariatric surgery.

ALT Data are least-squares mean (95% CI). Change from baseline in (A) total fat mass, (B) total lean mass, and (C) android visceral fat mass at week 36. Analysis included participants with non-missing baseline values and at least one non-missing postbaseline measurement.