@JamesLab9

Leo James' lab at MRC LMB in Cambridge, UK. Host-pathogen interactions, immunity to viruses, TRIM proteins and HIV. Account run by lab members.

 Cambridge, UK
Joined June 2022
  • Tweets114
  • Following228
  • Followers951
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Postdoc position in dendritic cell and cross-presentation biology - four days left to apply: mrc.tal.net/vx/mobile-0/appc… Join our team to work on these coolest cells ever! 🥰
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Join the RNA Virus Replication Lab @TheCrick, Europe's largest biomedical institute under 1 roof! 🔴 TWO postdocs (4-6yrs) 🔴 ONE PhD student (4yrs, fully funded, all🌍) We’re looking for bright, motivated people, with the chance to develop & shape projects independently... 1/n
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Researchers at @UKDRI and @MRC_LMB have developed two novel therapies that target tau aggregates in the brain and have shown promise in treating dementia in mice @w_mcewan @JamesLab9 biotechniques.com/proteomics…
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Scientists have developed potential therapies that selectively remove aggregated tau proteins and improve symptoms of neurodegeneration in mice, showing a promising approach for Alzheimer’s disease. More: orlo.uk/N50dm @UKDRI @MRC_LMB

New therapy that destroys tau tangles shows promise for Alzheimer’s

ukri.org
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The UK DRI's @w_mcewan & @JamesLab9 (@MRC_LMB) have developed new therapies that selectively remove aggregated tau proteins - harnessing the unique capabilities of a protein called TRIM21. The treatment improved symptoms of neurodegeneration in mice👉buff.ly/47ogpFG
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New research from @JamesLab9 & colleagues presents 'RING-Bait', which employs an aggregating protein sequence combined with an E3 ubiquitin ligase to specifically degrade tau aggregates while sparing soluble tau (in vitro & in vivo) - impressive new tech! cell.com/cell/fulltext/S0092…
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Leo James' Lab retweeted
Valeria Lulla@LullaValeria21 Mar 2024
We are looking for a research assistant/#postdoc in the molecular #virology lab to work @CamPathology @Cambridge_Uni The funding is advertised for 12 months but can be extended! Please DM if interested. Please RT! jobs.cam.ac.uk/job/45802/
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Leo James' Lab retweeted
Felix Randow@FelixRandow22 Mar 2024
Abstract deadline for the 4th @EMBO|@EMBL Symposium "Innate Immunity in Host-Pathogen Interactions" is next week (26.3.) Submit your abstract now for your chance to join a fabulous list of speakers in Heidelberg in June! Travel grants available. embl.org/about/info/course-a…
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Leo James' Lab retweeted
RM@rsbmilne13 Mar 2024
Flu and CoV-2. Do join us.
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So important to be frequently reminded of every single point in this list!
Ardem Patapoutian@ardemp18 Jan 2024
I wrote down my rules on how to Science. I hope you find it useful!
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Story out! An albumin fused ACE2 design that blocks all SARS-CoV-2 variants. The design has a long plasma half-life and can be delivered in a needle-free manner across mucosal surfaces. @CoE_PRIMA @UniOslo_MED @forskningsradet @NTNUnorway @JamesLab9 dx.doi.org/10.1093/pnasnexus…
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PhD Opportunities at the MRC University of Glasgow Centre for Virus Research (CVR). We have a team science approach to research, integrating laboratory-based, clinical and computational approaches to solve global challenges. All applications welcome. tinyurl.com/mzcfsfz8
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@_sophiestanford and @w_mcewan are researching how inflammation affects tau protein build-up in the brain, a key driver of Alzheimer’s disease. Look closely to see nerve cells (green), support cells (pink) and immune cells (white) - highlighted in the brain #ARUKImageOfTheWeek
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Leo James' Lab retweeted
Emma Thomson@emcat121 Aug 2023
Are you a virologist? Think about coming to do science with us. We have not one but two senior PI positions available at the CVR…
MRC-Uni of Glasgow Centre for Virus Research@CVRinfo18 Aug 2023
📢VACANCY | 2 Senior Lecturer/Prof Positions Are you leading a programme in virology complementary with our research programmes? Join the CVR team! We encourage applications from women, minority ethnic groups & non-standard career paths. gla.ac.uk/explore/jobs/?utm_… Ref 125249
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Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit #SARSCoV2 @JamesLab9 #COVID19 #virology #DrugDiscovery nature.com/articles/s41467-0…
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Bicyclic peptides against SARS-CoV-2! 🚴 🚨 Check out this study from Dr. Leo James (@JamesLab9) and team from @MRC_LMB published in @NatureComms. ⬇️
Leo James' Lab@JamesLab916 Jun 2023
Exciting new study from the lab published today! Excellent collaboration between @Bicycle_tx and academic labs to characterise new antiviral modality against #SARSCoV2 : Bicycle #antiviral #COVID19 #Spike rdcu.be/deGq1
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A good week for antiviral cyclic peptides! Our work is now online @PNASNews, and the work of @JamesLab9/@Bicycle_tx is out @NatureComms! 👇 xitter.cf/JamesLab9/status/16697…
CARE Consortium@reinhard_malin21 Jun 2023
A new study from @UtrechtVirology and collaborators describes a broad-spectrum macrocyclic peptide which targets a conserved binding pocket in the SARS-CoV-2 spike protein. Read more: bit.ly/44cnDtA #IHIEurope #Covid19 #CAREvsCOVID
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sciencedirect.com/science/ar… New work in @JMolBiol from the lab concerning the importance of producer-cell IP6 for HIV-1 Gag six-helix bundle (6HB) stability, viral assembly, and maturation. A great collaboration between the Freed lab, @GroupZhang, @JamesLab9, and @SaiardiLab.
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Leo James' Lab retweeted
EMBO Reports@emboreports28 Mar 2023
Leo James @JamesLab9 and co-workers @MRC_LMB show that IP6-stabilised #HIV capsids evade #cGAS/#STING-mediated host #immune sensing. #virology #AIDS #Immunity -> embopress.org/doi/full/10.15…
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3 years post-doctoral position in Virology (hijacking of cell signalling by African horse sickness virus) at the Vet school in the close suburb of Paris (fun team directed by Damien Vitour - not yet on Twitter - damien.vitour@vet-alfort.fr)
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