@JaffreyLab

Uncovering new principles in #RNA biology #epitranscriptome #aptamers. Tweets by grads/postdocs

 New York, NY
jaffreylab.org/blog
Joined October 2019
  • Tweets116
  • Following104
  • Followers1.1K
43Media
Surprising findings show phospholipids inside condensates throughout cells, not just in cell membranes, suggesting these compartments act as signaling centers, says Dr. Samie Jaffrey (@JaffreyLab) and colleagues. bit.ly/3RLES1t
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So excited to announce that my most recent work has been published. If you’re interested in genetically encoding circular mRNA, or packaging circular mRNA into virus-like particles for cell-type specific delivery, this paper is for you!
Cell Chemical Biology@CellChemBiol25 Oct 2023
Online now! Highly efficient cellular expression of circular mRNA enables prolonged protein expression by Mildred J. Unti @MildredUnti, and Samie R. Jaffrey @JaffreyLab at @WeillCornell #resource dlvr.it/SxxYbc #chembiol

Highly efficient cellular expression of circular mRNA enables prolonged protein expression

Unti et al. describe the Tornado translation system, a highly efficient method for generating circular mRNA in cells. The Tornado translation system outperforms previous methods for generating...

cell.com
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I had a blast presenting my work at the @NYCRNASymposium. Overall a fantastic event with great science.
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Study led by Dr. Samie R Jaffrey (@JaffreyLab) and Dr. Adrian Ferré-D'Amaré of @nih_nhlbi shows that DNA can fold into new shape to mimic function of other molecules. Findings could aid the development of certain types of rapid diagnostic tests. bit.ly/42Rf2vw
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Please join us this Thursday, May 4th at 3 PM for our first symposium of 2023! Register at forms.gle/75kd1uM7t5YMX3jT8
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New study led by Dr. Samie Jaffrey (@JaffreyLab) and Dr. Vladimir Despic shows that mRNAs contain chemical marks that are crucial for antiviral defense in cells and faulty mRNA modification may be linked to some autoimmune and inflammatory disorders. bit.ly/3WNsei2
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JaffreyLab retweeted
nature
@Nature1 Feb 2023
Nature research paper: mRNA ageing shapes the Cap2 methylome in mammalian mRNA go.nature.com/3jgqT5G
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Our #RNAday was a rousing success, complete with piRNA pizzas 🍕 and circRNA donuts 🍩! We thank all the speakers for the fantastic talks, everyone for coming, and @RNASociety @WeillCornell @MSKCancerCenter for the funding!!
Seminar room with someone raising their hand

ALT Seminar room with someone raising their hand

Outdoor terrace with people lining up for pizza and donuts

ALT Outdoor terrace with people lining up for pizza and donuts

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Tri-I RNA fans, please join us for our RNA day symposium with exciting talks, food, drinks, and games!! Free registration: forms.gle/9JG2zJ3ysMwKHbx89
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I am so happy 💙 to see Idalio Viegas’ PhD work published today. It is a story about #RNA modifications in poly(A) tails, but also about a broken arm and revision during lock down. Thanks to @FundlaCaixa @HHMINEWS and @EMBO_YIP. @parasitesrule nature.com/articles/s41586-0…
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Join us for our next session on Friday March 11 at 4 pm EST where we will host Dr. Samie Jaffrey and his postdoc Dr. Sara Zaccara from Cornell University. They will be talking all about m6A modifications so check your emails for the zoom link! @JaffreyLab @SaraZaccara
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Check out the News and Views on the Jaffrey and Ferré-d'Amaré papers by Abhishek Kaushik, Ashok Nuthanakanti and Alexander Serganov. Free to read: rdcu.be/cDIeK nature.com/articles/s41589-0…
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In a recent story highlighting noteworthy technologies from the last 15 years, @Nature featured 2013 @BlavatnikAwards Regional Award Winner Samie Jaffrey's exciting work at @JaffreyLab @WeillCornell in the emerging field of #epitranscriptomics. nature.com/articles/d41586-0…
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Jared Moon from the @JaffreyLab at @WeillCornell reports a three-way junction sensor platform as a versatile approach for making #RNA #sensors dlvr.it/S0Jd13

Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors

Genetically encoded RNA biosensors are an emerging tool for imaging small-molecule metabolites in cells. In this article, Moon et al. describe a versatile method for developing RNA biosensors by...

cell.com
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Replying to @AashiqHMirza
@Aashiq_H_Mirza is ready to quantify m6A with his brand-new toy. Stay tuned to know more about his incredible new discoveries!
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Amazing talk by @SamieJaffrey @JaffreyLab at @csi_singapore on “Deciphering the Epitranscriptomic Code in mRNA” with a summary on recent work by @SaraZaccara’s new model for DF reader function. sciencedirect.com/science/ar…
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Delighted to share our latest work on RNA acetylation (ac4C) now out @nature. A wonderful interdisciplinary journey in collaboration with the chemical @doc_jlmeier and structural Shalev-Benami labs, spearheaded by the one and only @AldemaSasChen. nature.com/articles/s41586-0…

Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

Nature - A method termed ac4C-seq is introduced for the transcriptome-wide mapping of the RNA modification N4-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates...

nature.com
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Today’s pick are two papers from @JaffreyLab and the Ferré-d’Amaré lab from our November 2017 issue. They identified and structurally characterized the RNA aptamer Corn, which binds DHFO with enhanced photostability. go.nature.com/3gvhctx. go.nature.com/36xEFGa. #NCHEMBIOGH
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Updated our paper to improve RNA modification detection "Limits in the detection of m6A changes using MeRIP/m6A-seq" All code is available. biorxiv.org/content/10.1101/…

Limits in the detection of m6A changes using MeRIP/m6A-seq

Many cellular mRNAs contain the modified base m6A, and recent studies have suggested that various stimuli can lead to changes in m6A. The most common method to map m6A and to predict changes in m6A...

biorxiv.org
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JaffreyLab retweeted
Arun Wiita@apwiita21 Nov 2019
Very cool from @ElementoLab, using #machinelearning to predict #cancer targets of known molecules + propose new drugs to hit a known target. Great mix of dry lab -> wet lab validation. Hope proves useful in real world! Too many drugs with poor MoA info.. nature.com/articles/s41467-0…

A Bayesian machine learning approach for drug target identification using diverse data types

Nature Communications - Drug target identification is a crucial step in drug development. Here, the authors introduce a Bayesian machine learning framework that integrates multiple data types to...

nature.com
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